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Editorial
Coronary artery imaging with multidetector computed tomography: A call for an evidence-based, multidisciplinary approach Paul Schoenhagen, Arthur E. Stillman, Mario J. Garcia, Sandra S. Halliburton, E. Murat Tuzcu, Steven E. Nissen, Michael T. Modic, Bruce W. Lytle, Eric J. Topol, Richard D. White pages 945-948 Abstract | Full Text | Full-Text PDF (72 KB)
Trial Design
Management of elderly patients with congestive heart failure—Design of the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) Hans Peter Brunner–La Rocca, Peter Theo Buser, Ruth Schindler, Alain Bernheim, Peter Rickenbacher, Matthias Pfisterer, for the TIME-CHF-Investigators pages 949-955 Abstract | Full Text | Full-Text PDF (164 KB)
The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients with Atrial Fibrillation) Trial Rebecca Brown Fountain, David R. Holmes, Krishnaswamy Chandrasekaran, Douglas Packer, Samuel Asirvatham, Robert Van Tassel, Zoltan Turi pages 956-961 Full Text | Full-Text PDF (183 KB)
Results of Expert Meetings
24-Hour ambulatory blood pressure monitoring J. Conor O'Shea, Robert M. Califf pages 962-968 Full Text | Full-Text PDF (115 KB)
Clinical Investigations
Prevention and Rehabilitation
Missed opportunities in the secondary prevention of myocardial infarction: An assessment of the effects of statin underprescribing on mortality Peter C. Austin, Muhammad M. Mamdani, David N. Juurlink, David A. Alter, Jack V. Tu pages 969-975 Abstract | Full Text | Full-Text PDF (181 KB)
Achieving LDL cholesterol, non-HDL cholesterol, and apolipoprotein B target levels in high-risk patients: Measuring Effective Reductions in Cholesterol Using Rosuvastatin therapY (MERCURY) II Christie M. Ballantyne, Marcelo Bertolami, Hugo Ricardo Hernandez Garcia, Daniel Nul, Evan A. Stein, Pierre Theroux, Robert Weiss, Valerie A. Cain, Joel S. Raichlen pages 975.e1-975.e9 Abstract | Full Text | Full-Text PDF (286 KB)
Statins are associated with lower risk of gastrointestinal bleeding in patients with unstable coronary syndromes: Analysis of the Orbofiban in Patients with Unstable coronary Syndromes–Thrombolysis In Myocardial Infarction 16 (OPUS-TIMI 16) trial Shaul Atar, Christopher P. Cannon, Sabina A. Murphy, Salvatore Rosanio, Barry F. Uretsky, Yochai Birnbaum pages 976.e1-976.e6 Abstract | Full Text | Full-Text PDF (207 KB)
Lack of effect of enteric coating on aspirin-induced inhibition of platelet aggregation in healthy volunteers Juhana Karha, Vivek Rajagopal, Kandice Kottke-Marchant, Deepak L. Bhatt pages 976.e7-976.e11 Abstract | Full Text | Full-Text PDF (138 KB)
Periodontal infections cause changes in traditional and novel cardiovascular risk factors: Results from a randomized controlled clinical trial Francesco D'Aiuto, Mohamed Parkar, Luigi Nibali, Jean Suvan, Jan Lessem, Maurizio S. Tonetti pages 977-984 Abstract | Full Text | Full-Text PDF (232 KB)
Congestive Heart Failure
Relationship of dose of background angiotensin-converting enzyme inhibitor to the benefits of candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)–Added trial John J.V. McMurray, James B. Young, Mark E. Dunlap, Christopher B. Granger, James Hainer, Eric L. Michelson, Steven Earle, Bertil Olofsson, Jan Östergren, Salim Yusuf, Karl Swedberg, Marc A. Pfeffer, on behalf of the CHARM Investigators pages 985-991 Abstract | Full Text | Full-Text PDF (384 KB)
Multifaceted intervention to promote β-blocker use in heart failure Nancy M. Allen LaPointe, Elizabeth R. DeLong, Anita Chen, Bradley G. Hammill, Lawrence H. Muhlbaier, Robert M. Califf, Judith M. Kramer pages 992-998 Abstract | Full Text | Full-Text PDF (176 KB)
How obesity affects the cut-points for B-type natriuretic peptide in the diagnosis of acute heart failure: Results from the Breathing Not Properly Multinational Study Lori B. Daniels, Paul Clopton, Vikas Bhalla, Padma Krishnaswamy, Richard M. Nowak, James McCord, Judd E. Hollander, Philippe Duc, Torbjørn Omland, Alan B. Storrow, William T. Abraham, Alan H.B. Wu, Philippe G. Steg, Arne Westheim, Cathrine Wold Knudsen, Alberto Perez, Radmila Kazanegra, Howard C. Herrmann, Peter A. McCullough, Alan S. Maisel pages 999-1005 Abstract | Full Text | Full-Text PDF (260 KB)
Gray zone BNP levels in heart failure patients in the emergency department: Results from the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT) multicenter study Cynthia K. Brenden, Judd E. Hollander, David Guss, Peter A. McCullough, Richard Nowak, Gary Green, Mitchell Saltzberg, Stefanie R. Ellison, Meenakshi Awasthi Bhalla, Vikas Bhalla, Paul Clopton, Robert Jesse, Alan S. Maisel, for the REDHOT Investigators pages 1006-1011 Abstract | Full Text | Full-Text PDF (171 KB)
Low prevalence of B-type natriuretic peptide levels <100 pg/mL in patients with heart failure at hospital discharge Jochem Hogenhuis, Adriaan A. Voors, Tiny Jaarsma, Hans L. Hillege, Arno W. Hoes, Dirk J. van Veldhuisen pages 1012.e1-1012.e5 Abstract | Full Text | Full-Text PDF (142 KB)
Intrafamilial variability of noncompaction of the ventricular myocardium Mark T. Johnson, Shaoxiong Zhang, Robert Gilkeson, Rebecca Ameduri, Ernest Siwik, Chandrakant R. Patel, Oleg Chebotarev, Alexander B. Kenton, Karla R. Bowles, Jeffrey A. Towbin, Nathaniel H. Robin, Frank Brozovich, Brian D. Hoit pages 1012.e7-1012.e14 Abstract | Full Text | Full-Text PDF (942 KB)
Hospital cost effect of a heart failure disease management program: The Specialized Primary and Networked Care in Heart Failure (SPAN-CHF) trial Douglas Gregory, Carey Kimmelstiel, Kathleen Perry, Amay Parikh, Varda Konstam, Marvin A. Konstam pages 1013-1018 Abstract | Full Text | Full-Text PDF (214 KB)
Interventional Cardiology
Sirolimus-eluting coronary stents in small vessels Bernhard Meier, Eduardo Sousa, Giulio Guagliumi, Frank Van den Branden, Ehud Grenadier, Stephan Windecker, Hans te Riele, Vasilis Voudris, Hélène Eltchaninoff, Bo Lindvall, David Snead, Aly Talen, for the SVELTE Study Group pages 1019.e1-1019.e7 Abstract | Full Text | Full-Text PDF (115 KB)
Coronary plaque composition of nonculprit lesions, assessed by in vivo intracoronary ultrasound radio frequency data analysis, is related to clinical presentation Gastón A. Rodriguez-Granillo, Eugène P. Mc Fadden, Marco Valgimigli, Carlos A.G. van Mieghem, Evelyn Regar, Pim J. de Feyter, Patrick W. Serruys pages 1020-1024 Abstract | Full Text | Full-Text PDF (149 KB)
In vivo relationship between compositional and mechanical imaging of coronary arteries: Insights from intravascular ultrasound radiofrequency data analysis Gastón A. Rodriguez-Granillo, Héctor M. García-García, Marco Valgimigli, Johannes A. Schaar, Ravindra Pawar, William J. van der Giessen, Evelyn Regar, Antonius F.W. van der Steen, Pim J. de Feyter, Patrick W. Serruys pages 1025.e1-1025.e6 Abstract | Full Text | Full-Text PDF (130 KB)
Influence of sex on in-hospital outcomes and long-term survival after contemporary percutaneous coronary intervention Jeffrey S. Berger, Timothy A. Sanborn, Warren Sherman, David L. Brown pages 1026-1031 Abstract | Full Text | Full-Text PDF (140 KB)
Preprocedural statin use is associated with a reduced hazard of postprocedural myonecrosis in patients undergoing rotational atherectomy—a propensity-adjusted analysis Hitinder S. Gurm, Yuri Breitbart, Deepak Vivekanathan, Michael H. Yen, Robert Fathi, Khaled M. Ziada, Patrick L. Whitlow, Stephen G. Ellis pages 1031.e1-1031.e6 Abstract | Full Text | Full-Text PDF (124 KB)
Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)–2 trial Matthews Chacko, A. Michael Lincoff, Katherine E. Wolski, David J. Cohen, John A. Bittl, Alexandra J. Lansky, Yoshihiro Tsuchiya, Amadeo Betriu, Michael H. Yen, Derek P. Chew, Leslie Cho, Eric J. Topol pages 1032.e1-1032.e7 Abstract | Full Text | Full-Text PDF (141 KB)
Acetylcysteine In Diabetes (AID): A randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics Louis C. Coyle, Antonio Rodriguez, Robert E. Jeschke, Anabela Simon-Lee, Kevin C. Abbott, Allen J. Taylor pages 1032.e9-1032.e12 Abstract | Full Text | Full-Text PDF (124 KB)
Outcomes, Health Policy, and Managed Care
Effects of a statewide physician-led quality-improvement program on the quality of cardiac care J. Richard Goss, Charles Maynard, Gabriel S. Aldea, Miriam Marcus-Smith, Richard W. Whitten, Gilbert Johnston, Richard C. Phillips, Mark Reisman, Ann Kelley, Richard P. Anderson, for the Clinical Outcomes Assessment Program (COAP) pages 1033-1042 Abstract | Full Text | Full-Text PDF (401 KB)
Electrophysiology
Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm Edward L.C. Pritchett, Peter Kowey, Stuart Connolly, Richard L. Page, Charles Kerr, William E. Wilkinson, For the A-COMET-I Investigators pages 1043-1049 Abstract | Full Text | Full-Text PDF (112 KB)
Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy: The Resynchronization for the HemodYnamic Treatment for Heart Failure Management II implantable cardioverter defibrillator (RHYTHM II ICD) study Giuseppe Boriani, Cord Paul Müller, Karl Heinz Seidl, Rainer Grove, Jürgen Vogt, Wilfried Danschel, Andreas Schuchert, Pierre Djiane, Mauro Biffi, Thorsten Becker, Christophe Bailleul, Hans Joachim Trappe, for the Resynchronization for the HemodYnamic Treatment for Heart Failure Management II (RHYTHM II) investigators pages 1050-1058 Abstract | Full Text | Full-Text PDF (593 KB)
Pediatrics
Diagnostic conclusions from the EASI-derived 12-lead electrocardiogram as compared with the standard 12-lead electrocardiogram in children Annika Welinder, Dirk Q. Feild, Jerome Liebman, Charles Maynard, Galen S. Wagner, Göran Wettrell, Olle Pahlm pages 1059-1064 Abstract | Full Text | Full-Text PDF (127 KB)
Acute Ischemic Heart Disease
Comparison of long-term mortality across the spectrum of acute coronary syndromes Larry A. Allen, Christopher J. O'Donnell, Carlos A. Camargo, Robert P. Giugliano, Donald M. Lloyd-Jones pages 1065-1071 Abstract | Full Text | Full-Text PDF (206 KB)
Blood pressure control and cardiovascular outcomes in high-risk Hispanic patients—Findings From the International Verapamil SR/Trandolapril Study (INVEST) Rhonda M. Cooper-DeHoff, Juan M. Aranda, Efrain Gaxiola, Jose L. Cangiano, David Garcia-Barreto, C. Richard Conti, Ann Hewkin, Carl J. Pepine, for the INVEST Investigators pages 1072-1079 Abstract | Full Text | Full-Text PDF (229 KB)
Electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetes Aida Jimenez-Corona, Robert G. Nelson, Maurice L. Sievers, William C. Knowler, Robert L. Hanson, Peter H. Bennett pages 1080-1086 Abstract | Full Text | Full-Text PDF (137 KB)
Increased cardiovascular risk associated with diabetes in Dallas County Sandeep R. Das, Patrice A.C. Vaeth, Harold G. Stanek, James A. de Lemos, Robert L. Dobbins, Darren K. McGuire pages 1087-1093 Abstract | Full Text | Full-Text PDF (204 KB)
NT–probrain natriuretic peptide predicts complexity and severity of the coronary lesions in patients with non–ST-elevation acute coronary syndromes José Luis Navarro Estrada, Fernando Rubinstein, Maria Cecilia Bahit, Florencia Rolandi, Diego Perez de Arenaza, Jose M. Gabay, Jose Alvarez, Ricardo Sarmiento, Carlos Rojas Matas, Carlos Sztejfman, Alejandro Tettamanzi, Raul de Miguel, Luis Guzman, on behalf of PACS Investigators pages 1093.e1-1093.e7 Abstract | Full Text | Full-Text PDF (244 KB)
Effect of comorbidity on coronary reperfusion strategy and long-term mortality after acute myocardial infarction Daniela Balzi, Alessandro Barchielli, Eva Buiatti, Caterina Franceschini, Rinaldo Lavecchia, Matteo Monami, Giovanni Maria Santoro, Nazario Carrabba, Massimo Margheri, Iacopo Olivotto, Gian Franco Gensini, Niccolò Marchionni, for the AMI-Florence Working Group pages 1094-1100 Abstract | Full Text | Full-Text PDF (181 KB)
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction Erdal Cavusoglu, Cyril Ruwende, Vineet Chopra, Sunitha Yanamadala, Calvin Eng, Luther T. Clark, David J. Pinsky, Jonathan D. Marmur pages 1101.e1-1101.e8 Abstract | Full Text | Full-Text PDF (223 KB)
Platelet microaggregation inhibition in patients with acute myocardial infarction pretreated with tirofiban and relationship with angiographic and clinical outcome Jaap Jan J. Smit, Nicolette M.S.K.J. Ernst, Robbert J. Slingerland, J.J. Evelien Kolkman, Harry Suryapranata, Jan C.A. Hoorntje, Jan Henk Dambrink, Jan Paul Ottervanger, A.T. Marcel Gosselink, Menko Jan de Boer, Arnoud W.J. van't Hof, On-TIME study group pages 1102-1107 Abstract | Full Text | Full-Text PDF (140 KB)
Coronary Artery Disease
Handgrip-enhanced myocardial fractional flow reserve for assessment of coronary artery stenoses Demosthenes G. Katritsis, Socrates Korovesis, Evangelia Karvouni, Eleftherios Giazitzoglou, Ilias Karabinos, Efthalia Tzanalaridou, Demosthenes Panagiotakos, Michael M. Webb-Peploe pages 1107.e1-1107.e7 Abstract | Full Text | Full-Text PDF (137 KB)
Imaging and Diagnostic Testing
Sestamibi single photon emission computed tomography immediately after primary percutaneous coronary intervention identifies patients at risk for large infarcts Anne Kaltoft, Morten Bøttcher, Niels Peter Sand, Michael Rehling, Niels Trolle Andersen, Felix Zijlstra, Torsten Toftegaard Nielsen pages 1108-1114 Abstract | Full Text | Full-Text PDF (267 KB)
Elevated plasma N-terminal pro–brain natriuretic peptide levels in acute ischemic stroke Kenan Iltumur, Aziz Karabulut, Ismail Apak, Ufuk Aluclu, Zuhal Ariturk, Nizamettin Toprak pages 1115-1122 Abstract | Full Text | Full-Text PDF (294 KB)
Depression symptoms predict heart rate recovery after treadmill stress testing Joel W. Hughes, Elizabeth Casey, Faith Luyster, Vicki H. Doe, Donna Waechter, James Rosneck, Richard Josephson pages 1122.e1-1122.e6 Abstract | Full Text | Full-Text PDF (135 KB)
Peripheral Vascular Disease
Association of peripheral artery disease with treatment and outcomes in acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE) James B. Froehlich, Debabrata Mukherjee, Alvaro Avezum, Andrzej Budaj, Eva M. Kline-Rogers, José López-Sendón, Jeanna Allegrone, Kim A. Eagle, Rajendra H. Mehta, Robert J. Goldberg, for the GRACE Investigators pages 1123-1128 Abstract | Full Text | Full-Text PDF (137 KB)
Valvular and Congenital Heart Disease
Assessment of patent foramen ovale in carcinoid heart disease Nicolas Mansencal, Emmanuel Mitry, Jean-François Forissier, Fabrice Martin, Alban Redheuil, Céline Lepère, Jean-Christian Farcot, Thierry Joseph, Pascal Lacombe, Philippe Rougier, Olivier Dubourg pages 1129.e1-1129.e6 Abstract | Full Text | Full-Text PDF (104 KB)
Analysis of factors related to successful transcatheter closure of secundum atrial septal defects using the HELEX septal occluder Larry A. Latson, Thomas K. Jones, Joth Jacobson, Evan Zahn, John F. Rhodes pages 1129.e7-1129.e11 Abstract | Full Text | Full-Text PDF (88 KB)
Letters to the Editor
Letter to the Editor Ira D. Galin, Donald A. Smith page e1 Full Text | Full-Text PDF (36 KB)
The vulnerable endothelium: priming the vascular endothelium for thrombosis with unfractionated heparin: biologic plausibility for observations from the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial (Am J Heart 2005;150:189-92) Atul Aggarwal page e3 Full Text | Full-Text PDF (44 KB)
Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting Atul Aggarwal page e5 Full Text | Full-Text PDF (38 KB)
Response to Aggarwal, Inflammatory response after intervention assesed by serial C-reactive protein measurements correlates with resterosis in patients with coronary stenting (Am Heart J 2005;150:344-50) Alban Dibra, Albert Schömig, Adnan Kastrati page e7 Full Text | Full-Text PDF (46 KB)
Letter to the Editor Niels P. Riksen, Paul Smits, Gerard A. Rongen page e9 Full Text | Full-Text PDF (39 KB)
What mediated the beneficial roles of methotrexate in chronic heart failure? Kaizheng Gong, Zhengang Zhang, Guojie Song pages e11-e12 Full Text | Full-Text PDF (49 KB)
Schizophrenia and increased risk of cardiovascular disease Paul Mackin, Hamish McAllister-Williams page e13 Full Text | Full-Text PDF (43 KB)
Frontmatter
Table of Contents pages A1-A6 Full-Text PDF (168 KB)
Editorial Board page A7 Full-Text PDF (35 KB)
Information for Authors page A8 Full-Text PDF (58 KB)
Information for Authors page A9 Full-Text PDF (46 KB)
Information for Readers page A10 Full-Text PDF (46 KB)
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