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Editorial
Tackling the challenge of cardiovascular disease burden in developing countries Salim Yusuf, Mario Vaz, Prem Pais pages 1-4 Full Text | Full-Text PDF (101 KB)
Coronary revascularization and quality of life Mark A Hlatky pages 5-6 Full Text | Full-Text PDF (57 KB)
Curriculum in cardiology
Coronary artery disease in the developing world Karen Okrainec, Devi K Banerjee, Mark J Eisenberg pages 7-15 Abstract | Full Text | Full-Text PDF (170 KB)
Concept and usefulness of cardiovascular risk profiles William B Kannel, Ralph B D'Agostino, Lisa Sullivan, Peter W.F Wilson pages 16-26 Abstract | Full Text | Full-Text PDF (290 KB)
On the move? page 26 Full Text | Full-Text PDF (64 KB)
Symptoms in acute coronary syndromes: does sex make a difference? Harshida Patel, Annika Rosengren, Inger Ekman pages 27-33 Abstract | Full Text | Full-Text PDF (128 KB)
Progress in cardiology
Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials Adam Splaver, Gervasio A Lamas, Charles H Hennekens pages 34-40 Abstract | Full Text | Full-Text PDF (126 KB)
Evidence-based consult
Should we cross the valve: the risk of retrograde catheterization of the left ventricle in patients with aortic stenosis Trip J Meine, J.Kevin Harrison pages 41-42 Abstract | Abstract + References | Full-Text PDF (50 KB)
Trial design
Organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF): rationale and design Gregg C Fonarow, William T Abraham, Nancy M Albert, Wendy A Gattis, Mihai Gheorghiade, Barry Greenberg, Chris M O'Connor, Clyde W Yancy, James Young pages 43-51 Abstract | Full Text | Full-Text PDF (276 KB)
Clinical investigations
Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials The ONTARGET/TRANSCEND Investigators pages 52-61 Abstract | Full Text | Full-Text PDF (148 KB)
Dynamic prognostication in non-ST–elevation acute coronary syndromes: insights from GUSTO-IIB and pursuit Wei-Ching Chang, Eric Boersma, Christopher B Granger, Robert A Harrington, Robert M Califf, Maarten L Simoons, Neal S Kleiman, Paul W Armstrong, GUSTO-IIb and PURSUIT Investigators pages 62-71 Abstract | Full Text | Full-Text PDF (222 KB)
Effects of a brief course of azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome: a double-blind, randomized, placebo-controlled study Graham S Hillis, Claire V Pearson, Scott A Harding, Sheena Sutherland, Christopher A Ludlam, John C Marioni, Robin J Prescott, Keith A.A Fox, Andrew D Flapan pages 72-79 Abstract | Full Text | Full-Text PDF (137 KB)
Electrocardiographic poor R-wave progression: analysis of multiple criteria reveals little usefulness Apoor S Gami, Thomas A Holly, James E Rosenthal pages 80-85 Abstract | Full Text | Full-Text PDF (158 KB)
Hyperbaric oxygen treatment does not affect left ventricular chamber stiffness after myocardial infarction treated with thrombolysis Alja Vlahović, Aleksandar N Nešković, Milica Dekleva, Biljana Putniković, Zoran B Popović, Petar Otašević, Miodrag Ostojić page 85 Abstract | Full Text | Full-Text PDF (140 KB)
Predictors of intracranial hemorrhage with fibrinolytic therapy in unselected community patients: a report from the FASTRAK II project Thao Huynh, Jafna L Cox, David Massel, Cheryl Davies, Joseph Hilbe, Wayne Warnica, Paul A Daly, FASTRAK II Network pages 86-91 Abstract | Full Text | Full-Text PDF (129 KB)
Effect of pravastatin compared with placebo initiated within 24 hours of onset of acute myocardial infarction or unstable angina: The Pravastatin in Acute Coronary Treatment (PACT) trial Peter L Thompson, Ian Meredith, John Amerena, Terence J Campbell, J.Graeme Sloman, Phillip J Harris, Pravastatin in Acute Coronary Treatment (PACT) Investigators page 91 Abstract | Full Text | Full-Text PDF (158 KB)
Relation of age and race with hospital death after acute myocardial infarction Ajay Manhapra, John G Canto, Viola Vaccarino, Lori Parsons, Catarina I Kiefe, Hal V Barron, William J Rogers, W.Douglas Weaver, Steven Borzak pages 92-98 Abstract | Full Text | Full-Text PDF (141 KB)
Accuracy of medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records Yuka Kiyota, Sebastian Schneeweiss, Robert J Glynn, Carolyn C Cannuscio, Jerry Avorn, Daniel H Solomon pages 99-104 Abstract | Full Text | Full-Text PDF (133 KB)
A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy Jürgen Pache, Adnan Kastrati, Julinda Mehilli, Hildegard Bollwein, Gjin Ndrepepa, Helmut Schühlen, Stefan Martinoff, Melchior Seyfarth, Stephan Nekolla, Josef Dirschinger, Markus Schwaiger, Albert Schömig page 105 Abstract | Full Text | Full-Text PDF (130 KB)
Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterolemia and a high risk of coronary heart disease: a randomized, controlled trial Gregory G Schwartz, Michael A Bolognese, Benoit P Tremblay, Richard Caplan, Howard Hutchinson, Ali Raza, Michael Cressman page 105 Abstract | Full Text | Full-Text PDF (202 KB)
Cost-effectiveness of using electron beam computed tomography to identify patients at risk for clinical coronary artery disease Patrick G O'Malley, Bruce A Greenberg, Allen J Taylor pages 106-113 Abstract | Full Text | Full-Text PDF (152 KB)
Invasive treatment in unstable coronary artery disease promotes health-related quality of life: results from the FRISC II trial Magnus Janzon, Lars-Åke Levin, Eva Swahn pages 114-121 Abstract | Full Text | Full-Text PDF (172 KB)
Multinational economic evaluation of valsartan in patients with chronic heart failure: results from the Valsartan Heart Failure Trial (Val-HeFT) Shelby D Reed, Joëlle Y Friedman, Eric J Velazquez, Ari Gnanasakthy, Robert M Califf, Kevin A Schulman pages 122-128 Abstract | Full Text | Full-Text PDF (159 KB)
Incremental value of cardiac imaging in patients presenting to the emergency department with chest pain and without ST-segment elevation: a multicenter study Sanjiv Kaul, Roxy Senior, Christian Firschke, Xin-Qun Wang, Jonathan Lindner, Flordeliza S Villanueva, Soroosh Firozan, Michael C Kontos, Allen Taylor, Ian J Nixon, Denny D Watson, Frank E Harrell pages 129-136 Abstract | Full Text | Full-Text PDF (238 KB)
In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography Hiroaki Taniguchi, Yukihiko Momiyama, Zahi A Fayad, Reiko Ohmori, Kazuhiro Ashida, Teruyoshi Kihara, Akiko Hara, Koh Arakawa, Akira Kameyama, Kumiko Noya, Masayoshi Nagata, Haruo Nakamura, Fumitaka Ohsuzu pages 137-143 Abstract | Full Text | Full-Text PDF (234 KB)
Biomechanical and echocardiographic characterization of flail mitral leaflet due to myxomatous disease: further evidence for early surgical intervention William R Mills, J.Edward Barber, Norman B Ratliff, Delos M Cosgrove, Ivan Vesely, Brian P Griffin pages 144-150 Abstract | Full Text | Full-Text PDF (303 KB)
Racial differences in the outcomes of patients with diastolic heart failure Mark A East, Eric D Peterson, Linda K Shaw, Wendy A Gattis, Christopher M O'Connor pages 151-156 Abstract | Full Text | Full-Text PDF (118 KB)
The Warfarin/Aspirin study in heart failure (WASH): a randomized trial comparing antithrombotic strategies for patients with heart failure J.G.F Cleland, I Findlay, S Jafri, G Sutton, R Falk, C Bulpitt, C Prentice, I Ford, Adele Trainer, P.A Poole-Wilson pages 157-164 Abstract | Full Text | Full-Text PDF (138 KB)
Impaired renal function in patients with ischemic and nonischemic chronic heart failure: association with neurohormonal activation and survival Tom D.J. Smilde, Hans L. Hillege, Gerjan Navis, Frans Boomsma, Dick de Zeeuw, Dirk J. van Veldhuisen pages 165-172 Abstract | Full Text | Full-Text PDF (159 KB)
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension C Napoli, V Sica, F de Nigris, O Pignalosa, M Condorelli, L.J Ignarro, A Liguori page 172 Abstract | Full Text | Full-Text PDF (156 KB)
Validated risk score predicts the development of congestive heart failure after presentation with unstable angina or non-ST–elevation myocardial infarction: results from OPUS-TIMI 16 and TACTICS-TIMI 18 John V Wylie, Sabina A Murphy, David A Morrow, James A de Lemos, Elliott M Antman, Christopher P Cannon pages 173-180 Abstract | Full Text | Full-Text PDF (173 KB)
Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) Pilot Study Roberto Lorenzoni, Guido Lazzerini, Franca Cocci, Raffaele De Caterina page 180 Abstract | Full Text | Full-Text PDF (145 KB)
Association between transforming growth factor-β1 gene C-509T and T869C polymorphisms and rheumatic heart disease Hsiang-Tai Chou, Chien-Hsiun Chen, Chang-Hai Tsai, Fuu-Jen Tsai pages 181-186 Abstract | Full Text | Full-Text PDF (109 KB)
Information for readers page CO3 Full-Text PDF (31 KB)
Letter to the editor
Hippocrates on heart failure Tsung O Cheng pages e1-e2 Full Text | Full-Text PDF (56 KB)
Frontmatter
Table of contents pages A4-A7 Full-Text PDF (95 KB)
Editorial board page A8 Full-Text PDF (34 KB)
Information for authors pages A9-A10 Full-Text PDF (73 KB)
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