| Editorial |
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A case where the principle of “one question, one answer” may work better
In the last decade, investigations on the use of drug-eluting stents (DES) for the treatment of coronary artery disease have generated 2 types of reaction: immense enthusiasm promoted by the ability o...
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Tomohisa Tada,
Robert A. Byrne,
Adnan Kastrati
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133-135
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| Trial Design |
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Newest-generation drug-eluting and bare-metal stents combined with prasugrel-based antiplatelet therapy in large coronary arteries: The BAsel Stent Kosten Effektivitäts Trial PROspective Validation Examination part II (BASKET-PROVE II) trial design
Background: In the BAsel Stent Kosten Effektivitäts Trial PROspective Validation Examination (BASKET-PROVE), drug-eluting stents (DESs) had similar 2-year rates of death and myocardial infarction but ...
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Raban Jeger,
Matthias Pfisterer,
Hannes Alber,
Franz Eberli,
Søren Galatius,
Christoph Naber,
Giovanni Pedrazzini,
Hans Rickli,
Jan Skov Jensen,
André Vuilliomenet,
Nicole Gilgen,
Christoph Kaiser
et al.
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136-141.e1
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Rationale and design of the TAXUS Libertē Post-Approval Study: Examination of patients receiving the TAXUS Liberté stent with concomitant prasugrel therapy in routine interventional cardiology practice
Background: Observational studies of new coronary stents are necessary to assess performance in a variety of complex patient and lesion types. Furthermore, the optimal dose and duration of thienopyrid...
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Kirk N. Garratt,
David P. Lee,
Eileen M. Rose,
Kellie J. Windle,
Hsini Liao,
Chuke E. Nwachuku,
Kenneth J. Winters,
Thomas S. Bowman,
Keith D. Dawkins
et al.
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142-148.e6
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Design of the RELAXin in Acute Heart Failure Study
Background: Acute heart failure (AHF) remains a major public health burden with a high prevalence and poor prognosis. Relaxin is a naturally occurring peptide hormone that increases cardiac output, ar...
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Piotr Ponikowski,
Marco Metra,
John R. Teerlink,
Elaine Unemori,
G. Michael Felker,
Adriaan A. Voors,
Gerasimos Filippatos,
Barry Greenberg,
Sam L. Teichman,
Thomas Severin,
Guenther Mueller-Velten,
Gad Cotter,
Beth A. Davison
et al.
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149-155.e1
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| Progress in Cardiology |
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Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors
Background: Interfering with angiogenesis is an effective, widely used approach to cancer therapy, but antiangiogenic therapies have been associated with important systemic cardiovascular toxicities s...
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Richard M. Steingart,
George L. Bakris,
Helen X. Chen,
Ming-Hui Chen,
Thomas Force,
S. Percy Ivy,
Carl V. Leier,
Glenn Liu,
Daniel Lenihan,
JoAnn Lindenfeld,
Michael L. Maitland,
Scot C. Remick,
W.H. Wilson Tang
et al.
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156-163
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| Clinical Investigations |
| Acute Ischemic Heart Disease |
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Detection of periodontal bacteria in thrombi of patients with acute myocardial infarction by polymerase chain reaction
Backgrounds: Numerous reports have demonstrated that periodontal bacteria are present in plaques from atherosclerotic arteries. Although periodontitis has recently been recognized as a risk factor for...
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Takahiro Ohki,
Yuji Itabashi,
Takashi Kohno,
Akihiro Yoshizawa,
Shuichi Nishikubo,
Shinya Watanabe,
Genyuki Yamane,
Kazuyuki Ishihara
et al.
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164-167
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High-concentration versus titrated oxygen therapy in ST-elevation myocardial infarction: A pilot randomized controlled trial
16 January 2012
Background: The optimal approach to oxygen therapy in ST-elevation myocardial infarction (STEMI) is uncertain. Methods: A randomized controlled trial was undertaken in which 136 patients presenting wi...
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Anil M. Ranchord,
Rachel Argyle,
Rhys Beynon,
Kyle Perrin,
Vishal Sharma,
Mark Weatherall,
Mark Simmonds,
Grant Heatlie,
Nicholas Brooks,
Richard Beasley
et al.
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168-175
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Efficacy and safety of enoxaparin compared with unfractionated heparin in the pharmacoinvasive management of acute ST-segment elevation myocardial infarction: Insights from the TRANSFER-AMI trial
Aims: An early invasive strategy after fibrinolysis for ST-elevation myocardial infarction (STEMI) improves outcomes, but the relative efficacy and safety of enoxaparin compared with unfractionated he...
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Shahar Lavi,
Warren J. Cantor,
Amparo Casanova,
Mary K. Tan,
Andrew T. Yan,
Vladimír Džavík,
David Fitchett,
Eric A. Cohen,
Bjug Borgundvaag,
Michael Heffernan,
John Ducas,
Shaun G. Goodman
et al.
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176-181.e2
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Reduced immediate ischemic events with cangrelor in PCI: A pooled analysis of the CHAMPION trials using the universal definition of myocardial infarction
Background: There is a clinical need for an intravenous P2Y12 inhibitor in patients with acute coronary syndromes (ACS) for patients who are unable to take oral medications or might benefit from a rap...
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Harvey D. White,
Derek P. Chew,
Harold L. Dauerman,
Kenneth W. Mahaffey,
C. Michael Gibson,
Gregg W. Stone,
Luis Gruberg,
Robert A. Harrington,
Deepak L. Bhatt
et al.
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182-190.e4
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Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis
Background: Systemic therapy with statin has been shown to lower the risk of coronary events; however, the in vivo effects of statin therapy on plaque volume and composition are less understood. Metho...
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Tsuyoshi Nozue,
Shingo Yamamoto,
Shinichi Tohyama,
Shigeo Umezawa,
Tomoyuki Kunishima,
Akira Sato,
Shogo Miyake,
Youichi Takeyama,
Yoshihiro Morino,
Takao Yamauchi,
Toshiya Muramatsu,
Kiyoshi Hibi,
Takashi Sozu,
Mitsuyasu Terashima,
Ichiro Michishita
et al.
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191-199.e1
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Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the Erythropoietin in Myocardial Infarction Trial
Background: Preclinical studies and pilot clinical trials have shown that high-dose erythropoietin (EPO) reduces infarct size in acute myocardial infarction. We investigated whether a single high-dose...
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Fabrice Prunier,
Loïc Bière,
Martine Gilard,
Jacques Boschat,
Frédéric Mouquet,
Jean-Jacques Bauchart,
Bernard Charbonnier,
Olivier Genée,
Patrice Guérin,
Karine Warin-Fresse,
Eric Durand,
Antoine Lafont,
Luc Christiaens,
Wissam Abi-Khalil,
Stéphane Delépine,
Thomas Benard,
Alain Furber
et al.
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200-207.e1
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Circadian variations of ischemic burden among patients with myocardial infarction undergoing primary percutaneous coronary intervention
Background: Several parameters of cardiovascular physiology and pathophysiology exhibit circadian rhythms. Recently, a relation between infarct size and the time of day at which it occurs has been sug...
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Stephane Fournier,
Eric Eeckhout,
Fabio Mangiacapra,
Catalina Trana,
Nathalie Lauriers,
Ahmed T. Beggah,
Pierre Monney,
Stephane Cook,
Daniel Bardy,
Pierre Vogt,
Olivier Muller
et al.
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208-213
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| Interventional Cardiology |
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Indications for percutaneous coronary interventions performed in US hospitals: a report from the NCDR®
Background: There are many factors hypothesized as contributing to overuse of percutaneous coronary intervention (PCI) in the United States, including financial ties between physicians and hospitals, ...
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Peter Cram,
John A. House,
John C. Messenger,
Robert N. Piana,
Phillip A Horwitz,
John A. Spertus
et al.
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214-221.e1
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Percutaneous coronary intervention outcomes in US hospitals with varying structural characteristics: Analysis of the NCDR®
Background: In the United States, there continues to be debate about whether certain types of hospitals deliver improved patient outcomes. We sought to assess the association between hospital organiza...
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Peter Cram,
John A. House,
John C. Messenger,
Robert N. Piana,
Phillip A. Horwitz,
John A. Spertus
et al.
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222-229.e1
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Vascular complications and access crossover in 10,676 transradial percutaneous coronary procedures
16 January 2012
Background: Randomized trials have shown that transradial approach, compared with transfemoral, reduces vascular complications (VCs) of coronary procedures in selected patients. Yet, radial approach i...
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Francesco Burzotta,
Carlo Trani,
Mario Attilio Mazzari,
Antonella Tommasino,
Giampaolo Niccoli,
Italo Porto,
Antonio Maria Leone,
Giovanni Tinelli,
Valentina Coluccia,
Maria De Vita,
Marta Brancati,
Rocco Mongiardo,
Giovanni Schiavoni,
Filippo Crea
et al.
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230-238
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| Outcomes, Health Policy, and Managed Care |
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Patient and hospital characteristics associated with traditional measures of inpatient quality of care for patients with heart failure
Background: The purpose of this study was to determine patient and hospital characteristics associated with 4 measures of quality of inpatient heart failure care used by both the primary payer of hear...
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Paul A. Heidenreich,
Xin Zhao,
Adrian F. Hernandez,
Clyde W. Yancy,
Gregg C. Fonarow
et al.
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239-245.e3
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| Congestive Heart Failure |
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Perceived sexual difficulties and associated factors in patients with heart failure
Background: Sexual dysfunction is a common problem of increasing incidence in patients with heart failure (HF). However, there is no knowledge on which demographic, clinical, and quality of life (QoL)...
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Tialda Hoekstra,
Tiny Jaarsma,
Robbert Sanderman,
Dirk J. van Veldhuisen,
Ivonne Lesman-Leegte
et al.
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246-251
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Comparison of processes of care and clinical outcomes for patients newly hospitalized for heart failure attended by different physician specialists
Background: Previous studies suggest that patients with heart failure (HF) treated by cardiologists have improved outcomes compared with patients treated by other physicians. It remains unclear whethe...
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Nicole K. Boom,
Douglas S. Lee,
Jack V. Tu
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252-259
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Effect of QRS morphology on clinical event reduction with cardiac resynchronization therapy: Meta-analysis of randomized controlled trials
Background: Cardiac resynchronization therapy (CRT) is effective in reducing clinical events in systolic heart failure patients with a wide QRS. Previous retrospective studies suggest only patients wi...
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Ilke Sipahi,
Josephine C. Chou,
Marshall Hyden,
Douglas Y. Rowland,
Daniel I. Simon,
James C. Fang
et al.
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260-267.e3
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| Coronary Artery Disease |
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Frequency and impact of lifestyle modification in patients with coronary artery disease: The Japanese Coronary Artery Disease (JCAD) Study
Background: Lifestyle modifications such as exercise and diet interventions in patients with coronary artery disease (CAD) are widely regarded as important, but little is known about their frequency i...
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Takeki Suzuki,
Takahide Kohro,
Doubun Hayashi,
Tsutomu Yamazaki,
Ryozo Nagai
et al.
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268-273
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Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: Data from the Heart and Soul Study
Background: Pentraxin-3 (PTX3) is an inflammatory marker thought to be more specific to vascular inflammation than C-reactive protein (CRP). Whether PTX3 is independently associated with adverse event...
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Ruth Dubin,
Yongmei Li,
Joachim H. Ix,
Michael G. Shlipak,
Mary Whooley,
Carmen A. Peralta
et al.
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274-279
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| Valvular and Congenital Heart Disease |
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Cardiopulmonary exercise function among patients undergoing transcatheter pulmonary valve implantation in the US Melody valve investigational trial
Objectives: We assessed the hypothesis that there is an improvement in clinical and physiologic parameters of cardiopulmonary exercise testing (CPET) after implantation of a transcatheter pulmonary va...
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Anjan S. Batra,
Doff B. McElhinney,
Wayne Wang,
Richard Zakheim,
Robert P. Garofano,
Curt Daniels,
Delphine Yung,
Dan M. Cooper,
Jonathan Rhodes
et al.
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280-287
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Survival and predictive factors of mortality after 30 days in patients treated with percutaneous implantation of the CoreValve aortic prosthesis
Background: Few data exist on the clinical impact of transcatheter aortic valve implantation (TAVI) in patients with symptomatic aortic stenosis and a high surgical risk. The aim of this study was to ...
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Antonio J. Muñoz-García,
José M. Hernández-García,
Manuel F. Jiménez-Navarro,
Juan H. Alonso-Briales,
Antonio J. Domínguez-Franco,
Isabel Rodríguez-Bailón,
María J. Molina-Mora,
Paula Hernández-Rodríguez,
Miguel Such-Martínez,
Eduardo de Teresa-Galván
et al.
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288-294
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| Pediatrics |
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Aggregating traditional cardiovascular disease risk factors to assess the cardiometabolic health of childhood cancer survivors: An analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study
Background: Childhood cancer survivors are at increased risk of cardiovascular disease (CVD), which may be associated with traditional CVD risk factors. We used CVD risk aggregation instruments to des...
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David C. Landy,
Tracie L. Miller,
Gabriela Lopez-Mitnik,
Stuart R. Lipsitz,
Andrea S. Hinkle,
Louis S. Constine,
Carol A. French,
Amy M.K. Rovitelli,
M. Jacob Adams,
Steven E. Lipshultz
et al.
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295-301.e2
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Obesity and physical fitness in California school children
Background: Obesity rates have reached epidemic proportions in the United States and California. Thus, the California Department of Education began a series of steps to address the increase in obesity...
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Melanie Aryana,
Zhongmin Li,
William J. Bommer
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302-312
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| Frontmatter |
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Table of Contents
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A1-A4
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Editorial Board
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A7
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Information for Readers
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A8
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