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Trial Design
Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: Design and rationale Renato D. Lopes, John H. Alexander, Sana M. Al-Khatib, Jack Ansell, Raphael Diaz, J. Donald Easton, Bernard J. Gersh, Christopher B. Granger, Michael Hanna, John Horowitz, Elaine M. Hylek, John J.V. McMurray, Freek W.A. Verheugt, Lars Wallentin, on behalf of the ARISTOTLE Investigators pages 331-339 Abstract | Full Text | Full-Text PDF (372 KB)
Rivaroxaban—Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: Rationale and Design of the ROCKET AF study The Executive Steering Committee, on behalf of the ROCKET AF Study Investigators pages 340-347.e1 Abstract | Full Text | Full-Text PDF (242 KB)
Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment John W. Eikelboom, Martin O'Donnell, Salim Yusuf, Rafael Diaz, Greg Flaker, Robert Hart, Stefan Hohnloser, Campbell Joyner, Jack Lawrence, Prem Pais, Janice Pogue, David Synhorst, Stuart J. Connolly pages 348-353.e1 Abstract | Full Text | Full-Text PDF (208 KB)
Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): The first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction Monica Taljaard, Michael R. Ward, Michael J.B. Kutryk, David W. Courtman, Nancy J. Camack, Shaun G. Goodman, Thomas G. Parker, Alexander J. Dick, Jacques Galipeau, Duncan J. Stewart pages 354-360 Abstract | Full Text | Full-Text PDF (343 KB)
Rationale, design, and baseline data of the Japanese Primary Prevention Project (JPPP)—A randomized, open-label, controlled trial of aspirin versus no aspirin in patients with multiple risk factors for vascular events Tamio Teramoto, Kazuyuki Shimada, Shinichiro Uchiyama, Masahiro Sugawara, Yoshio Goto, Nobuhiro Yamada, Shinichi Oikawa, Katsuyuki Ando, Naoki Ishizuka, Tsutomu Yamazaki, Kenji Yokoyama, Mitsuru Murata, Yasuo Ikeda pages 361-369.e4 Abstract | Full Text | Full-Text PDF (418 KB)
Clinical Investigations
Electrophysiology
In-hospital management of patients with atrial flutter Nancy M. Allen LaPointe, Jie-Lena Sun, Sigal Kaplan pages 370-376 Abstract | Full Text | Full-Text PDF (148 KB)
Acute Ischemic Heart Disease
Evidence of disparity in the application of quality improvement efforts for the treatment of acute myocardial infarction: The American College of Cardiology's Guidelines Applied in Practice Initiative in Michigan Adesuwa B. Olomu, Mary Grzybowski, Vijay S. Ramanath, Adam M. Rogers, Bonnie Motyka Vautaw, Benrong Chen, Canopy Roychoudhury, Elizabeth A. Jackson, Kim A. Eagle, for the American College of Cardiology Foundation Guidelines Applied in Practice Steering Committee pages 377-384 Abstract | Full Text | Full-Text PDF (297 KB)
Variations in prevalent cardiovascular disease and future risk by metabolic syndrome classification in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study Todd M. Brown, Jenifer H. Voeks, Vera Bittner, Monika M. Safford pages 385-391 Abstract | Full Text | Full-Text PDF (127 KB)
Differences in mortality in acute coronary syndrome symptom clusters Barbara Riegel, Alexandra L. Hanlon, Sharon McKinley, Debra K. Moser, Hendrika Meischke, Lynn V. Doering, Patricia Davidson, Michele M. Pelter, Kathleen Dracup pages 392-398 Abstract | Full Text | Full-Text PDF (305 KB)
Coronary Artery Disease
Cuff and aortic pressure differences during dobutamine infusion: A study of the effects of systolic blood pressure amplification Harold Smulyan, Ratnakar Mukherjee, Paul R. Sheehe, Michel E. Safar pages 399-405 Abstract | Full Text | Full-Text PDF (365 KB)
Congestive Heart Failure
Relationships between emerging measures of heart failure processes of care and clinical outcomes Adrian F. Hernandez, Bradley G. Hammill, Eric D. Peterson, Clyde W. Yancy, Kevin A. Schulman, Lesley H. Curtis, Gregg C. Fonarow pages 406-413 Abstract | Full Text | Full-Text PDF (309 KB)
Myocardial structure and function by echocardiography in relation to glucometabolic status in elderly subjects from 2 population-based cohorts: A cross-sectional study Margret Leosdottir, Ronnie Willenheimer, Jonathan Plehn, Rasmus Borgquist, Petri Gudmundsson, Tamara B. Harris, Lenore J. Launer, Halldora Bjornsdottir, Peter M. Nilsson, Vilmundur Gudnason pages 414-420.e4 Abstract | Full Text | Full-Text PDF (173 KB)
Detection of elevated right atrial pressure using a simple bedside ultrasound measure Marc A. Simon, Dustin E. Kliner, John P. Girod, Diego Moguillansky, Flordeliza S. Villanueva, John J. Pacella pages 421-427 Abstract | Full Text | Full-Text PDF (465 KB)
Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses Soko Setoguchi, John M. Higgins, Helen Mogun, Vamsi K. Mootha, Jerry Avorn pages 428-433 Abstract | Full Text | Full-Text PDF (126 KB)
Interventional Cardiology
Clinical relevance of clopidogrel unresponsiveness during elective coronary stenting: Experience with the point-of-care Platelet Function Assay–100 C/ADP Catherine M. Moerenhout, Marc J. Claeys, Steven Haine, Hielko Miljoen, Johan M. Bosmans, Francine Vertessen, Katrien Kluppels, Marc Van der Planken, Christiaan J. Vrints pages 434-438 Abstract | Full Text | Full-Text PDF (122 KB)
Mechanisms of nonfatal acute myocardial infarction late after stent implantation: The relative impact of disease progression, stent restenosis, and stent thrombosis Dimitrios Alexopoulos, Ioanna Xanthopoulou, Periklis Davlouros, Anastasia Damelou, Andreas Mazarakis, John Chiladakis, George Hahalis pages 439-445 Abstract | Full Text | Full-Text PDF (363 KB)
Does “late catch-up” exist in drug-eluting stents: Insights from a serial quantitative coronary angiography analysis of sirolimus versus paclitaxel-eluting stents Kyung Woo Park, Chi-Hoon Kim, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim pages 446-453.e3 Abstract | Full Text | Full-Text PDF (383 KB)
Long-term outcome of percutaneous catheter intervention for de novo coronary bifurcation lesions with drug-eluting stents or bare-metal stents Miroslaw Ferenc, Michael Gick, Rolf-Peter Kienzle, Hans-Peter Bestehorn, Klaus-Dieter Werner, Thomas Comberg, Min Zhao, Heinz Joachim Buettner, Franz-Josef Neumann pages 454-461 Abstract | Full Text | Full-Text PDF (612 KB)
Clopidogrel use and clinical events after drug-eluting stent implantation: Findings from the HealthCore Integrated Research Database John L. Petersen, John J. Barron, Bradley G. Hammill, Mark J. Cziraky, Kevin J. Anstrom, Peter M. Wahl, Eric L. Eisenstein, Mitchell W. Krucoff, Robert M. Califf, Kevin A. Schulman, Lesley H. Curtis pages 462-470.e1 Abstract | Full Text | Full-Text PDF (493 KB)
Outcomes, Health Policy, and Managed Care
Health-related quality of life and long-term mortality in patients treated with percutaneous coronary intervention Lisanne Schenkeveld, Susanne S. Pedersen, Josephine W.I. van Nierop, Mattie J. Lenzen, Peter P.T. de Jaegere, Patrick W. Serruys, Ron T. van Domburg pages 471-476 Abstract | Full Text | Full-Text PDF (365 KB)
Imaging and Diagnostic Testing
Trends in echocardiography utilization in the Veterans Administration Healthcare System Kingston Okrah, Mary Vaughan-Sarrazin, Peter Cram pages 477-483 Abstract | Full Text | Full-Text PDF (219 KB)
Temporal trends in compliance with appropriateness criteria for stress single-photon emission computed tomography sestamibi studies in an academic medical center Raymond J. Gibbons, J. Wells Askew, David Hodge, Todd D. Miller pages 484-489 Abstract | Full Text | Full-Text PDF (268 KB)
Surgery
Timing of nonemergent coronary artery bypass grafting and mortality after non-ST elevation acute coronary syndrome Marc W. Deyell, William A. Ghali, David B. Ross, Jianguo Zhang, Brenda R. Hemmelgarn, for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators pages 490-496 Abstract | Full Text | Full-Text PDF (197 KB)
Valvular and Congenital Heart Disease
Factors associated with cardiac conduction disorders and permanent pacemaker implantation after percutaneous aortic valve implantation with the CoreValve prosthesis Jan Baan, Ze Yie Yong, Karel T. Koch, José P.S. Henriques, Berto J. Bouma, Marije M. Vis, Riccardo Cocchieri, Jan J. Piek, Bas A.J.M. de Mol pages 497-503 Abstract | Full Text | Full-Text PDF (265 KB)
Letters to the Editor
Effect of interval (V-V) optimization in ischemic versus nonischemic patients after cardiac resynchronization therapy Fu Yi, Jin Yu, Bing Liu page e11 Full Text | Full-Text PDF (54 KB)
Reply to the Letter to the Editor by Yi et al Nina Ajmone Marsan, Jeroen J. Bax page e13 Full Text | Full-Text PDF (50 KB)
Brain natriuretic peptide for cardiovascular events independent of left ventricular end-diastolic pressure Viroj Wiwanitkit page e15 Full Text | Full-Text PDF (44 KB)
Author response: B-type natriuretic peptide for cardiovascular events independent of left ventricular end-diastolic pressure Kevin Rogers page e17 Full Text | Full-Text PDF (51 KB)
Low vitamin D may explain the link between preeclampsia and cardiovascular disease William B. Grant page e19 Full Text | Full-Text PDF (56 KB)
“High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation: A randomized controlled trial evaluating the relationship to endothelial function and inflammation.” Am Heart J 2009;158:734-41 Philippe Meyer, Mathieu Gayda, Éve Normandin, Thibaut Guiraud, Martin Juneau, Anil Nigam page e21 Full Text | Full-Text PDF (58 KB)
Frontmatter
Contents pages A1-A4 Full-Text PDF (81 KB)
Editorial Board page A5 Full-Text PDF (37 KB)
Information for Readers page A6 Full-Text PDF (34 KB)
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