Clinical InvestigationElectrophysiologyVitamin D status is not related to development of atrial fibrillation in the community
Section snippets
Study sample
The study sample was derived from the Original and Offspring cohorts of the Framingham Heart Study. The Original cohort was established in 1948 and included 5,209 residents of Framingham, Massachusetts, USA.22 Between 1988 and 1989, 1,130 participants attended the 20th biennial examination and had measurement of 25(OH)D levels. Since 25-hydroxyvitamin D (25[OH]D) is the precursor of the biologically active form of vitamin D (1,25[OH]D) and integrates endogenous synthesis with intake from diet
Characteristics
In total, 2,930 participants without prevalent AF, 1,046 from the Original cohort and 1,884 from the Offspring cohort, were included in the analysis. The characteristics of the study sample are shown in Table I. In the Original cohort, the mean age of participants was 76 ± 6 years, and 63% were women. In the Offspring cohort, the mean age of participants was 60 ± 9 years, and 53% were women.
Multivariable analyses
During a mean follow-up of 9.9 ± 4.0 years, 425 participants (15%) developed AF. The results of the
Discussion
In summary, we found no association between vitamin D status and the development of AF in a large, community-based cohort. The validity of our results is supported by the large sample size, the routine ascertainment of both vitamin D status and AF events, the consistency of our findings in the diverse multivariable models, and the analyses adequately powered to detect a moderate effect size. To our knowledge, this is the first study to examine the relation of vitamin D deficiency with the
Disclosures
Dr. Wang has participated on the scientific advisory board of Diasorin, Inc. He is an investigator on a study sponsored by Diasorin, Inc.
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Vitamin D and cardiovascular diseases
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2022, American Journal of CardiologyCitation Excerpt :In contrast, the Rotterdam Study,18 including 3,395 participants with the median age of 71 years old and Vit-D deficiency defined as (25-OH)D levels <50 nmol/L (<20 ng/ml), found no association between Vit-D status and incidence of AF over the median of 12 years. Similarly, the ARIC (Atherosclerosis Risk in Communities) study6 and the Framingham Heart Study,19 with a median follow-up of 21 and 9.9 years respectively, did not find any difference in AF events between the individuals with (25-OH)D levels of <20 ng/ml versus individuals with levels ≥30 ng/ml. Notably, in both these studies, the serum 25(OH)D levels were measured only once early in the study, and no further levels were measured, therefore potentially not reflecting 25(OH)D values during the onset of AF in the studied populations.
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Sources of funding: This work was supported by grants from the National Institutes of Health (NO1-HC-25195, K23-HL-074077, R01-AG14759, K23-RR-017376-04, and K24-HL-04334; 1R01HL092577; 1RC1HL101056; 1R01HL102214; 6R01-NS 17950; 1R01HL092577; R01AG028321; 5R21DA027021; 5RO1HL104156; 1K24HL105780), the US Department of Agriculture (agreement 58-1950-4-401), and the American Heart Association. Dr Rienstra is supported by a grant from the Netherlands Organization for Scientific Research (Rubicon Grant 825.09.020). Dr Cheng is supported by a grant from the Ellison Foundation. Dr Magnani is supported by American Heart Association Award 09FTF2190028. This work was partially supported by the Evans Center for Interdisciplinary Biomedical Research ARC on Atrial Fibrillation Initiative at Boston University.