Clinical InvestigationPrevention and RehabilitationRace-ethnic differences in the association between lipid profile components and risk of myocardial infarction: The Northern Manhattan Study
Section snippets
Recruitment of the cohort
The Northern Manhattan Study is a population-based study designed to evaluate the impact of medical, socioeconomic, and other risk factors on the incidence of vascular disease in a stroke-free multiethnic community cohort. Participants were identified by dual-frame random digit dialing in Northern Manhattan as previously described9 and were eligible if they met the following criteria: (1) had never been diagnosed with a stroke; (2) were >39 years old; and (3) resided in Northern Manhattan for
Results
Baseline characteristics for the cohort are outlined in Table I. The mean age of the cohort was 68.8 ± 10.4 years; 36.7% were men. Most of the participants (n = 1,445, 52.8%) were Hispanic, with similar proportions of non-Hispanic blacks and whites making up the rest of the cohort; 45.8% of participants completed high school. There were no significant differences in the proportion of women in each race-ethnicity category. Overall, Hispanics and non-Hispanic blacks had a higher burden of CHD
Discussion
In keeping with prior investigations,7, 17 the mean HDL-C was lower and mean TG was higher in our study among Hispanics compared with non-Hispanic blacks or whites. Non-Hispanic blacks also had a less atherogenic lipid profile than non-Hispanic whites, although we found that the risk of MI was similar for non-Hispanic whites and non-Hispanic blacks except for the models including TG. In our main finding of the TG/HDL-C, non-Hispanic blacks and whites were similar. Compared with results from the
Disclosures
The authors report no conflicts of interest.
References (30)
- et al.
Comparison of modifiable determinants of lipids and lipoprotein levels among African-Americans, Hispanics, and non-Hispanic Caucasians > or = 65 years of age living in New York City
Am J Cardiol
(2002) - et al.
The behavioral risk factor surveys: II. Design, methods, and estimates from combined state data
Am J Prev Med
(1985) - et al.
Usefulness of atherogenic dyslipidemia for predicting cardiovascular risk in patients with angiographically defined coronary artery disease
Am J Cardiol
(2007) - et al.
Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men
Am J Cardiol
(2009) - et al.
Usefulness of the triglyceride-high-density lipoprotein versus the cholesterol-high-density lipoprotein ratio for predicting insulin resistance and cardiometabolic risk (from the Framingham Offspring cohort)
Am J Cardiol
(2008) - et al.
Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B
Am J Cardiol
(2004) - et al.
Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Circulation
(2008) - et al.
Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders
Age Ageing
(2008) - et al.
Ethnic variation in cardiovascular disease risk factors among children and young adults: findings from the Third National Health and Nutrition Examination Survey, 1988-1994
JAMA
(1999) - et al.
Major lipids, apolipoproteins, and risk of vascular disease
JAMA
(2009)
The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: the Cardiovascular Health Study
J Am Geriatr Soc
Serum lipids and incidence of coronary heart disease. Findings from the Systolic Hypertension in the Elderly Program (SHEP)
Circulation
Disparities in screening for and awareness of high blood cholesterol—United States, 1999-2002
MMWR Morb Mortal Wkly Rep
Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study
Stroke
Cited by (43)
Triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular events in the general population: A systematic review and meta-analysis of cohort studies
2022, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :The mean ages of the included participants varied from 44.7 to 68.8 years old, with the proportion of male participants ranging from 33.8 to 100%. The baseline TG/HDL-C ratio was analyzed as a categorical variable in 9 studies [15,17,18,20–25], as a continuous variable in 3 studies [5,14,19], and as both in 1 study [16]. The number of CVD events of individual studies ranged from 51 to 5422.
Triglyceride to high-density lipoprotein cholesterol ratio and risk of atherosclerotic cardiovascular disease in a Chinese population
2020, Nutrition, Metabolism and Cardiovascular DiseasesLipidomes in health and disease: Analytical strategies and considerations
2019, TrAC - Trends in Analytical Chemistry
Funding sources: this project was supported by NINDSR37NS29993. J.Z.W was funded by NINDST32NS07153. C.J.R is supported by a Robert Wood Johnson; Harold Amos Medical Faculty Development Award; and a National Heart, Lung, and Blood Institute's Mentored Patient-Oriented Research Career Development Award (NHLBIK23HL079343-01A2).
The first author had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All of the authors meet criteria for authorship, including acceptance of responsibility for the scientific content of the article.