Clinical InvestigationHypertensionLack of association between serum magnesium and the risks of hypertension and cardiovascular disease
Section snippets
Study sample
The Framingham Heart Study began recruitment of an offspring cohort in 1971 with the enrollment of 5,124 children of the original Framingham Heart Study participants. Study design and selection criteria for this study have been previously described.39 Participants attending the second examination of the offspring cohort (n = 3,863), which took place between 1979 and 1982, were eligible for the current investigation. We excluded participants lacking a serum magnesium measurement (n = 176) or
Characteristics of the study sample
Baseline characteristics are shown in Table I for the samples used in the incident hypertension analyses (n = 2,520) and the incident CVD and mortality analyses (n = 3,531). There were 772 (22%) participants with prevalent hypertension at the baseline examination. The range of observed values for magnesium was 1.41 to 2.40 mg/dL in men and 1.15 to 2.46 mg/dL in women. The number of participants with serum magnesium <1.5 mg/dL was 12 for the hypertension analyses and 24 for the CVD and death
Discussion
We found no association between serum magnesium levels and the subsequent development of hypertension, CVD, or all-cause mortality. The validity of these findings is supported by the use of a large, well-characterized epidemiologic cohort, routine adjudication for incident hypertension and CVD, a large number of events, and standardized assessment of serum magnesium.
Our findings are in contrast to those of prior studies that have related magnesium status to cardiovascular outcomes.22, 23, 24, 25
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