American Heart Journal
Volume 160, Issue 2 , Pages 250-256.e3 , August 2010

Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease

  • Jeffrey L. Anderson, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT
    • Corresponding Author InformationReprint requests: Jeffrey L. Anderson, MD, Intermountain Medical Center; Cardiovascular Department. 5121 S. Cottonwood Street, Murray, UT 84107.
    • ,
  • Benjamin D. Horne, PhD, MPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Genetic Epidemiology Divisions, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Nicola J. Camp, PhD

      Affiliations

    • Genetic Epidemiology Divisions, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Joseph B. Muhlestein, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Paul N. Hopkins, MD, MPH

      Affiliations

    • Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Lisa A. Cannon-Albright, PhD

      Affiliations

    • Genetic Epidemiology Divisions, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Chrissa P. Mower, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • James J. Park, BA

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • Jessica L. Clarke, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • Zachary P. Nicholas, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • Jason T. McKinney, PhD

      Affiliations

    • Idaho Technology, Salt Lake City, UT
    • ,
  • John F. Carlquist, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT

Received 23 December 2009 ,Accepted 19 May 2010.

  • Image Result

    Prevalence of angiographic CAD by count GRS5 score. Percent CAD across GRS5 categories was highly significant (p trend = 8.2 × 10−11). Reference mean count GRS score is 6.3.

    Prevalence of angiographic CAD by count GRS5 score. Percent CAD across GRS5 categories was highly significant (p trend = 8.2 × 10−11). Reference mean count GRS score is 6.3.

  • Image Result

    Study Design Schematic. *Lipid-related genes studied were apoF, CETP, LCAT, LIPC, LPL, LCAT, SR-BI.

    Study Design Schematic. *Lipid-related genes studied were apoF, CETP, LCAT, LIPC, LPL, LCAT, SR-BI.

PII: S0002-8703(10)00437-0

doi: 10.1016/j.ahj.2010.05.031

American Heart Journal
Volume 160, Issue 2 , Pages 250-256.e3 , August 2010

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