American Heart Journal
Volume 160, Issue 2 , Pages 224-229 , August 2010

The new high-sensitivity cardiac troponin T assay improves risk assessment in acute coronary syndromes

  • Bertil Lindahl, MD, PhD

      Affiliations

    • Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, University of Uppsala, Sweden
    • Corresponding Author InformationReprint requests: Bertil Lindahl, MD, PhD, Uppsala Clinical Research center, University Hospital, SE-751 85 Uppsala, Sweden.
    • ,
  • Per Venge, MD, PhD

      Affiliations

    • Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    • ,
  • Stefan James, MD, PhD

      Affiliations

    • Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, University of Uppsala, Sweden

Received 14 March 2010 ,Accepted 6 May 2010.

References 

  1. Thygesen K, Alpert JS, White HD on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation. 2007;116:2634–2653
  2. Morrow DA, Cannon CP, Jesse RL, et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation. 2007;115:e356–e375
  3. Ottani F, Galvani M, Nicolini FA, et al. Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J. 2000;140:917–927
  4. Venge P, Lagerqvist B, Diderholm E, et al. Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy). Am J Cardiol. 2002;89:1035–1041
  5. Reichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361:858–867
  6. Giannitsis E, Kurz K, Hallermayer K, et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem. 2009;[Epub ahead of print]
  7. Eggers KM, Jaffe AS, Lind L, et al. Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making. Clin Chem. 2009;55:85–92
  8. GUSTO-IV-ACS-investigators . Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial. Lancet. 2001;357:1915–1924
  9. Cockcroft D, Gault M. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  10. Venge P, Johnston N, Lindahl B, et al. Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol. 2009;54:1165–1172
  11. Lindahl B, Diderholm E, Lagerqvist B, et al. Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: a FRISC II substudy. J Am Coll Cardiol. 2001;38:979–986
  12. Wilson S, Sabatine M, Braunwald E, et al. Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: observations from the PROTECT-TIMI 30 Trial. Am Heart J. 2009;158:386–391
  13. Eggers KM, Dellborg M, Oldgren J, et al. Risk prediction in chest pain patients by biochemical markers including estimates of renal function. Int J Cardiol. 2008;128:207–213

PII: S0002-8703(10)00429-1

doi: 10.1016/j.ahj.2010.05.023

American Heart Journal
Volume 160, Issue 2 , Pages 224-229 , August 2010

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