American Heart Journal
Volume 160, Issue 1 , Pages 49-57.e1 , July 2010

The BioImage Study: Novel approaches to risk assessment in the primary prevention of atherosclerotic cardiovascular disease—study design and objectives

  • Pieter Muntendam, MD

      Affiliations

    • BG Medicine Inc, Waltham, MA
  • ,
  • Carol McCall, FSA, MAAA

      Affiliations

    • Humana Inc, Louisville, KY
  • ,
  • Javier Sanz, MD

      Affiliations

    • The Mount Sinai School of Medicine, New York, NY
  • ,
  • Erling Falk, MD, PhD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital (Skejby), Aarhus, Denmark
  • ,
  • Valentin Fuster, MD, PhD

      Affiliations

    • The Mount Sinai School of Medicine, New York, NY
    • Centro Nacional de Investigaciones Cardiovasculares, Madrid (CNIC), Madrid, Spain
    • Corresponding Author InformationReprint requests: Valentin Fuster, MD, PhD, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA.
  • ,
  • for the High-Risk Plaque Initiative

      Affiliations

    • Additional investigators participating in the BioImage Study are listed in the online Appendix.

Received 26 August 2009 ,Accepted 11 February 2010.

  • Image Result

    BioImage Study flowchart.

    BioImage Study flowchart.

  • Image Result

    Putative relative event rates (A) by age, gender, and number of claims-based risk indicators and (B) by age in relation to presence or absence of specific claims-based risk indicators. Data are based

    Putative relative event rates (A) by age, gender, and number of claims-based risk indicators and (B) by age in relation to presence or absence of specific claims-based risk indicators. Data are based on 2-year follow-up in subjects from population described in Table I. The event rate for the total population =1.00. Pearson χ2 tests for each age group, gender, and indicator (except hyperlipidemia) were significant at P < .001.

  • Image Result
    Enrolled study population in comparison to the eligible population (Chicago location, preliminary data) for age, gender, income, and risk indicators. A, Distribution of female and male gender among Bi

    Enrolled study population in comparison to the eligible population (Chicago location, preliminary data) for age, gender, income, and risk indicators. A, Distribution of female and male gender among BioImage Study participants (P) by age group in comparison with the pool of eligible members (E) from which they were recruited. B, Household income as determined based on US Census information using census track mapping for BioImage Study participants, those eligible to participate, and those living in the Chicago metropolitan statistical area (Chicago-at-large) mapped to the same zip codes from which the eligible population is drawn. C, Presence of claims-based risk indicators among BioImage Study participants in comparison with the pool of eligible members from which they were recruited.

 Clinical trial registration: http://www.clinicaltrials.gov/ct2/show/NCT00738725?term = bioimage&rank=1.

PII: S0002-8703(10)00165-1

doi: 10.1016/j.ahj.2010.02.021

American Heart Journal
Volume 160, Issue 1 , Pages 49-57.e1 , July 2010