American Heart Journal
Volume 159, Issue 3 , Pages 414-420.e4 , March 2010

Myocardial structure and function by echocardiography in relation to glucometabolic status in elderly subjects from 2 population-based cohorts: A cross-sectional study

  • Margret Leosdottir, MD

      Affiliations

    • Department of Cardiology, Malmö University Hospital, Malmö, Sweden
    • Corresponding Author InformationReprint requests: Margret Leosdottir, MD, Department of Cardiology, Malmö University Hospital, 20502 Malmö, Sweden.
  • ,
  • Ronnie Willenheimer, MD, PhD

      Affiliations

    • Department of Clinical Sciences, Lund University, Malmö University Hospital, Malmö, Sweden
    • Heart Health Group, Malmö, Sweden
  • ,
  • Jonathan Plehn, MD

      Affiliations

    • Translational Medicine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD
  • ,
  • Rasmus Borgquist, MD, PhD

      Affiliations

    • Department of Cardiology, Lund University Hospital, Lund, Sweden
  • ,
  • Petri Gudmundsson, BSc, PhD

      Affiliations

    • Department of Biomedical Laboratory Science, Malmö University, Malmö, Sweden
  • ,
  • Tamara B. Harris, PhD

      Affiliations

    • Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, NIA, Bethesda, MD
  • ,
  • Lenore J. Launer, PhD

      Affiliations

    • Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, NIA, Bethesda, MD
  • ,
  • Halldora Bjornsdottir, MD

      Affiliations

    • Icelandic Heart Association, Kopavogur, Iceland
  • ,
  • Peter M. Nilsson, MD, PhD

      Affiliations

    • Department of Clinical Sciences, Lund University, Malmö University Hospital, Malmö, Sweden
  • ,
  • Vilmundur Gudnason, MD, PhD

      Affiliations

    • Icelandic Heart Association, Kopavogur, Iceland
    • University of Iceland, Reykjavik, Iceland

Received 8 March 2009 ,Accepted 14 December 2009.

References 

  1. Galderisi M, Anderson KM, Wilson PW, et al. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol. 1991;68:85–89
  2. Fang ZY, Schull-Meade R, Downey M, et al. Determinants of subclinical diabetic heart disease. Diabetologia. 2005;48:394–402
  3. Ilercil A, Devereux RB, Roman MJ, et al. Relationship of impaired glucose tolerance to left ventricular structure and function: the Strong Heart Study. Am Heart J. 2001;141:992–998
  4. Okura H., Inoue H., Tomon M., et al. Impaired glucose tolerance as a determinant of early deterioration of left ventricular diastolic function in middle-aged healthy subjects. Am J Cardiol 2000;85(6):790-2, A9.
  5. Fujita M, Asanuma H, Kim J, et al. Impaired glucose tolerance: a possible contributor to left ventricular hypertrophy and diastolic dysfunction. Int J Cardiol. 2007;118:76–80
  6. Nikitin NP, Witte KK. Application of tissue Doppler imaging in cardiology. Cardiology. 2004;101:170–184
  7. Holzmann M, Olsson A, Johansson J, et al. Left ventricular diastolic function is related to glucose in a middle-aged population. J Intern Med. 2002;251:415–420
  8. Kalogeropoulos A, Georgiopoulou V, Harris TB, et al. Glycemic status and incident heart failure in elderly without history of diabetes mellitus: the health, aging, and body composition study. J Card Fail. 2009;15:593–599
  9. Andren B, Lind L, Hedenstierna G, et al. Left ventricular diastolic function in a population sample of elderly men. Echocardiography. 1998;15:433–450
  10. Lee M, Gardin JM, Lynch JC, et al. Diabetes mellitus and echocardiographic left ventricular function in free-living elderly men and women: the Cardiovascular Health Study. Am Heart J. 1997;133:36–43
  11. Karvounis HI, Papadopoulos CE, Zaglavara TA, et al. Evidence of left ventricular dysfunction in asymptomatic elderly patients with non-insulin-dependent diabetes mellitus. Angiology. 2004;55:549–555
  12. Harris TB, Launer LJ, Eiriksdottir G, et al. Age, Gene/Environment Susceptibility–Reykjavik study: multidisciplinary applied phenomics. Am J Epidemiol. 2007;165:1076–1087
  13. Karl J, Burns G, Engel WD, et al. Development and standardization of a new immunoturbidimetric HbA1c assay. Klin Lab. 1993;39:991–996
  14. Berglund G, Nilsson P, Eriksson KF, et al. Long-term outcome of the Malmo preventive project: mortality and cardiovascular morbidity. J Intern Med. 2000;247:19–29
  15. Quinones MA, Otto CM, Stoddard M, et al. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 2002;15:167–184
  16. Khouri SJ, Maly GT, Suh DD, et al. A practical approach to the echocardiographic evaluation of diastolic function. J Am Soc Echocardiogr. 2004;17:290–297
  17. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–1463
  18. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  19. Hayat SA, Patel B, Khattar RS, et al. Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clin Sci (Lond). 2004;107:539–557
  20. Nikitin NP, Witte KK, Thackray SD, et al. Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging. J Am Soc Echocardiogr. 2003;16:906–921
  21. Sun JP, Popovic ZB, Greenberg NL, et al. Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging. J Am Soc Echocardiogr. 2004;17:132–138
  22. Nichols GA, Gullion CM, Koro CE, et al. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care. 2004;27:1879–1884
  23. Rutter MK, Parise H, Benjamin EJ, et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation. 2003;107:448–454
  24. Ebinc H, Ebinc FA, Ozkurt ZN, et al. Relationship of left ventricular mass to insulin sensitivity and body mass index in healthy individuals. Acta Cardiol. 2006;61:398–405
  25. Vaccaro O, Cardoni O, Cuomo V, et al. Relationship between plasma insulin and left ventricular mass in normotensive participants of the Gubbio Study. Clin Endocrinol (Oxf). 2003;58:316–322
  26. Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol. 1974;34:29–34

PII: S0002-8703(10)00067-0

doi: 10.1016/j.ahj.2009.12.028

American Heart Journal
Volume 159, Issue 3 , Pages 414-420.e4 , March 2010