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American Heart Journal
Volume 159, Issue 2
, Pages 245-257
, February 2010
Systematic review of trials using vasodilators in pulmonary arterial hypertension: Why a new approach is needed
References
- . The current treatment of pulmonary arterial hypertension: time to redefine success. Chest. 2006;130:1198–1202
- . The status of pulmonary arterial hypertension in 2008. Circulation. 2008;117:2966–2968
- . The value of approved therapies for pulmonary arterial hypertension. Am Heart J. 2007;153:889–890
- A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology. Am Heart J. 2007;153:1037–1047
- Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Ann Intern Med. 1990;112:485–491
- A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996;334:296–301
- Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. Ann Intern Med. 2000;132:425–434
- Aerosolized iloprost randomized study group. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med. 2002;347:322–329
- Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol. 2002;39:1496–1502
- Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2002;165:800–804
- Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol. 2003;41:2119–2125
- Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet. 2001;358:1119–1123
- Bosentan therapy for pulmonary arterial hypertension. N Engl J Med. 2002;346:896–903
- Sitaxsentan therapy for pulmonary arterial hypertension. Am J Respir Crit Care Med. 2004;169:441–447
- Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur J Respir. 2004;24:353–359
- Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med. 2002;136:515–522
- Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomized controlled trial. Lancet. 2002;360:895–900
- Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol. 2004;43:1149–1153
- Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med. 2005;353:2148–2157
- Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) Study. Am J Respir Crit Care Med. 2005;171:1292–1297
- Ambrisentan for the Treatment of Pulmonary Arterial Hypertension Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation. 2008;117:3010–3019
- Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol. 2006;47:2049–2056
- Randomized Trial of Endothelin Antagonist Therapy-5 (BREATHE-5) Investigators. Circulation. 2006;114:48–54
- Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet. 2008;371:2093–2100
- Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med. 2008;149:521–530
- A randomized, placebo-controlled, double-blind, crossover study to evaluate the efficacy of oral sildenafil therapy in severe pulmonary artery hypertension. Am Heart J. 2006;151:851.e1–851.e5
- Tadalafil therapy for pulmonary arterial hypertension. Circulation. 2009;119:2894–2903
- Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2006;174:1257–1263
- Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur Respir J. 2006;28:691–694
- Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation. 2005;111:3105–3111
- . The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med. 1992;327:76
- Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest. 2004;126:35S–62S
- Therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines. Chest. 2007;131:1917–1928
- . Beyond the randomized clinical trial. The role of effectiveness studies in evaluating cardiovascular therapies. Circulation. 2008;118:1294–1303
- . Meta-analysis, decision analysis, and cost-effectiveness analysis. London, UK: Oxford University Press; 1994;
- . Categorical data analysis. NewYork: John Wiley and Sons, Inc.; 1990;
- . Quantitative methods in the review of epidemiologic literature. Epidemiol Rev. 1987;9:1–30
- . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–1558
- . Using multivariate statistics. New York (NY): Harper Collins; 1996;
- . Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101
- Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629
- Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006;114:1482–1489
- . The 6-min walk test. Clinical and research role, technique, coding, and reimbursement. Chest. 2009;135:1345–1352
- Task Force. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J. 2004;25:2243–2278
- A meta-analysis of randomized controlled trials in pulmonary arterial hypertension. Eur Heart J. 2009;30:394–403
- Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA. 2009;301:831–841
- End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives. J Am Coll Cardiol. 2004;43:48S–55S
- Variable impact of combining fatal and nonfatal endpoints in heart failure trials. Circulation. 2006;114:2298–2303
- Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med. 1991;115:343–349
- . Pulmonary hypertension. Am J Respir Crit Care Med. 2005;172:1072–1077
- . Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension. Circulation. 2008;118:1195–1201
PII: S0002-8703(09)00953-3
doi: 10.1016/j.ahj.2009.11.028
© 2010 Mosby, Inc. All rights reserved.
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American Heart Journal
Volume 159, Issue 2
, Pages 245-257
, February 2010
