American Heart Journal
Volume 159, Issue 3 , Pages 331-339 , March 2010

Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: Design and rationale

  • Renato D. Lopes, MD, PhD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • John H. Alexander, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Sana M. Al-Khatib, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Jack Ansell, MD

      Affiliations

    • Lenox Hill Hospital, New York, NY
    • ,
  • Raphael Diaz, MD

      Affiliations

    • Estudios Cardiologicos Latinoamerica, Santa Fe, Argentina
    • ,
  • J. Donald Easton, MD

      Affiliations

    • Rhode Island Hospital, Alpert Medical School, Brown University, Providence, RI
    • ,
  • Bernard J. Gersh, MB, ChB, DPhil

      Affiliations

    • Mayo Clinic College of Medicine, Rochester, MN
    • ,
  • Christopher B. Granger, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • Corresponding Author InformationReprint requests: Christopher B. Granger, MD, Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311 Terrace Level, Durham, NC 27707.
    • ,
  • Michael Hanna, MD

      Affiliations

    • Bristol-Myers Squibb, Princeton, NJ
    • ,
  • John Horowitz, MD

      Affiliations

    • University of Adelaide, Adelaide, Australia
    • ,
  • Elaine M. Hylek, MD, MPH

      Affiliations

    • Boston University Medical Center, Boston, MA
    • ,
  • John J.V. McMurray, MD

      Affiliations

    • Western Infirmary, Glasgow, United Kingdom
    • ,
  • Freek W.A. Verheugt, MD, PhD

      Affiliations

    • University Medical Center, Nijmegen, The Netherlands
    • ,
  • Lars Wallentin, MD, PhD

      Affiliations

    • Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    • ,
  • on behalf of the ARISTOTLE Investigators

Received 6 February 2009 ,Accepted 7 July 2009.

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 RCT reg no. NCT00412984.

PII: S0002-8703(09)00945-4

doi: 10.1016/j.ahj.2009.07.035

American Heart Journal
Volume 159, Issue 3 , Pages 331-339 , March 2010

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