American Heart Journal
Volume 159, Issue 2 , Pages 264-270 , February 2010

Biventricular pacing improves cardiac function and prevents further left atrial remodeling in patients with symptomatic atrial fibrillation after atrioventricular node ablation

  • Michael V. Orlov, MD, PhD

      Affiliations

    • Caritas St Elizabeth's Medical Center, Boston, MA
    • Corresponding Author InformationReprint requests: Michael V. Orlov, MD, PhD, Caritas St Elizabeth's Medical Center, 736 Cambridge St, Boston, MA 02135.
  • ,
  • Julius M. Gardin, MD

      Affiliations

    • St John Medical Center, Detroit, MI
  • ,
  • Mara Slawsky, MD

      Affiliations

    • BayState Medical Center, Springfield, MA
  • ,
  • Renee L. Bess, BS, RDCS, RVT

      Affiliations

    • St John Medical Center, Detroit, MI
  • ,
  • Gerald Cohen, MD

      Affiliations

    • St John Medical Center, Detroit, MI
  • ,
  • William Bailey, MD

      Affiliations

    • Lake Charles Memorial Hospital, Lake Charles, LA
  • ,
  • Vance Plumb, MD

      Affiliations

    • University of Alabama, Birmingham, AL
  • ,
  • Horst Flathmann, PhD

      Affiliations

    • BIOTRONIK, Inc, Lake Oswego, OR
  • ,
  • Katerina de Metz, MS

      Affiliations

    • BIOTRONIK, Inc, Lake Oswego, OR

Received 1 July 2009 ,Accepted 12 November 2009.

References 

  1. Kay GN, Ellenbogen KA, Giudici M, et al. The ablate and pace trial: a prospective study of catheter ablation of the AV conduction system and permanent pacemaker implantation for treatment of atrial fibrillation. J Interv Card Electrophysiol. 1998;2:121–135
  2. Wood MA, Brown-Mahoney C, Kay GN, et al. Clinical outcomes after ablation and pacing therapy for atrial fibrillation: a meta-analysis. Circulation. 2000;101:1138–1144
  3. Brignole M, Gianfranchi L, Menozzi C, et al. Influence of atrioventricular junction radiofrequency ablation in patients with chronic atrial fibrillation and flutter on quality-of-life and cardiac performance. Am J Cardiol. 1994;74:242–246
  4. DAVID Trial Investigators . Dual-Chamber Pacing or Ventricular Backup Pacing in Patients with an Implantable Defibrillator—The Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA. 2002;288:3115–3123
  5. Moss AJ. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877–883
  6. Abraham WT. Cardiac resynchronization therapy: a review of clinical trials and criteria for identifying the appropriate patient. Rev in Cardiovasc Med. 2003;4(Suppl 2):S30–S37
  7. Leclercq C, Walker S, Linde C, et al. Comparative effects of permanent biventricular and right-univentricular pacing in heart failure patients with chronic atrial fibrillation. Eur Heart J. 2002;23:1780–1787
  8. PAVE Study Group. Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (the PAVE study). J Cardiovasc Electrophysiol. 2005;16:1160–1165
  9. Osswald S, Cron T, Graedel C. Closed-loop stimulation using intracardiac impedance as a sensor principle: correlation of right ventricular dP/dtmax and intracardiac impedance during dobutamine stress test. Pacing Clin Electrophysiol. 2000;23:1502–1508
  10. Pichlmaier AM, Braile D, Ebner E, et al. Autonomic nervous system controlled closed loop cardiac pacing. Pacing Clin Electrophysiol. 1992;15(11 Pt 2):1787–1791
  11. Griesbach L, Gestrich B, Wojciechowski D, et al. for the RAPID study investigators Clinical performance of automatic closed loop stimulation systems. Pacing Clin Electrophysiol. 2003;26:1432–1437
  12. Vijay N, de Metz K, Dolan M, et al. A prospective multicenter study demonstrating safety and effectiveness of closed loop stimulation. Prog in Biomed Res. 2001;6:397–401
  13. Lang RM, Bierig M, Devereux RB, et al. Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–1463
  14. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  15. Lipkin DP, Scriven AJ, Crake T, et al. Six-minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed). 1986;292:653–655
  16. Rector TS, Francis GS, Cohn JN. Patient's self-assessment of their congestive heart failure. Part 1 and part 2. Heart Fail. 1987;192–209
  17. Flaker GC, Fletcher KA, Rothbart RM, et al. Clinical and echocardiographic features of intermittent atrial fibrillation that predict recurrent atrial fibrillation. Am J Cardiol. 1995;76:355–358
  18. Olshansky B, Heller EN, Mitchell LB, et al. Are transthoracic echocardiographic parameters associated with atrial fibrillation recurrence or stroke. J Am Coll Cardiol. 2005;45:2026–2033
  19. Fung JW, Yu CM, Chan JY, et al. Effects of cardiac resynchronization therapy on incidence of atrial fibrillation in patients with poor left ventricular systolic function. Am J Cardiol. 2005;96:728–731
  20. Yannopoulos D, Lurie KG, Sakaguchi S, et al. Reduced atrial tachyarrhythmia susceptibility after upgrade of conventional implanted pulse generator to cardiac resynchronization therapy in patients with heart failure. J Am Coll Cardiol. 2007;50:1246–1251
  21. Hoppe UC, Casares JM, Eiskjaer H, et al. Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure. Circulation. 2006;114:18–25
  22. Brignole M, Gammage M, Puggioni E. Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation. Eur Heart J. 2005;26:712–722
  23. Leon AR, Greenberg JM, Kanuru N. Cardiac resynchronization in patients with congestive heart failure and chronic atrial fibrillation: effect of upgrading to biventricular pacing after chronic right ventricular pacing. J Am Coll Cardiol. 2002;39:1258–1263
  24. Tops LF, Schalij MJ, Holman ER, et al. Right ventricular pacing can induce ventricular dyssynchrony in patients with atrial fibrillation after atrioventricular node ablation. J Am Coll Cardiol. 2006;48:1642–1648
  25. Delgado V, Tops LF, Trines SA, et al. Acute effects of right ventricular apical pacing on left ventricular synchrony and mechanics. Circulation. 2009;2:135–145
  26. Brignole M, Menozzi C, Botto GL, et al. Usefulness of echo-guided cardiac resynchronization pacing in patients undergoing “ablate and pace” therapy for permanent atrial fibrillation and effects of heart rate regulation and left ventricular resynchronization. Am J Cardiol. 2008;102:854–860
  27. Orlov MV, Bailey W, Plumb VJ, et al. Improved heart rate distribution with closed loop stimulation after atrioventricular node ablation in symptomatic atrial fibrillation patients: preliminary results of the AVAIL CLS/CRT trial. Heart Rhythm. 2007;4:PO6–122
  28. Khan MN, Jais P, Cummings J, et al. Pulmonary-vein isolation for atrial fibrillation in patients with heart failure. N Engl J Med. 2008;359:1778–1785

 The study was registered on clinicaltrials.gov NCT00356057.

PII: S0002-8703(09)00884-9

doi: 10.1016/j.ahj.2009.11.012

American Heart Journal
Volume 159, Issue 2 , Pages 264-270 , February 2010