American Heart Journal
Volume 159, Issue 2 , Pages 271-277 , February 2010

Analysis of the long-term effects of drug-eluting stents on coronary arterial wall morphology as assessed by virtual histology intravascular ultrasound

  • Takashi Kubo, MD, PhD

      Affiliations

    • Cardiovascular Research Foundation, New York, NY
    • ,
  • Akiko Maehara, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, NY
    • Corresponding Author InformationReprint requests: Akiko Maehara, MD, Cardiovascular Research Foundation, 111 East, 59th St, New York, NY 10022.
    • ,
  • Gary S. Mintz, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, NY
    • ,
  • Hector M. Garcia-Garcia, MD, MSc

      Affiliations

    • Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    • ,
  • Patrick W. Serruys, MD, PhD

      Affiliations

    • Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    • ,
  • Takahiko Suzuki, MD

      Affiliations

    • Toyohashi Heart Center, Aichi, Japan
    • ,
  • Volker Klauss, MD

      Affiliations

    • Ludwig Maximilian University, Munich, Germany
    • ,
  • Satoru Sumitsuji, MD

      Affiliations

    • Nozaki Tokushukai Hospital, Osaka, Japan
    • ,
  • Amir Lerman, MD

      Affiliations

    • Mayo Clinic College of Medicine, Rochester, MN
    • ,
  • Steven P. Marso, MD

      Affiliations

    • Mid America Heart Institute of Saint Luke's Hospital, Kansas City, MO
    • ,
  • M. Pauliina Margolis, MD, PhD

      Affiliations

    • Volcano Corporation, Rancho Cordova, CA
    • ,
  • James R. Margolis, MD

      Affiliations

    • Miami International Cardiology Consultants, Miami, FL
    • ,
  • Michael C. Foster, MD

      Affiliations

    • South Carolina Heart Center, Columbia, SC
    • ,
  • Bernard De Bruyne, MD, PhD

      Affiliations

    • OLV Hospital, Aalst, Belgium
    • ,
  • Martin B. Leon, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, NY
    • ,
  • Gregg W. Stone, MD

      Affiliations

    • Cardiovascular Research Foundation, New York, NY

Received 23 June 2009 ,Accepted 10 November 2009.

References 

  1. Moses JW, Leon MB, Popma JJ, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315–1323
  2. Colombo A, Drzewiecki J, Banning A, et al. Randomized study to assess the effectiveness of slow- and moderate release polymer-based paclitaxel-eluting stents for coronary artery lesions. Circulation. 2003;108:788–794
  3. Finn AV, Nakazawa G, Joner M, et al. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol. 2007;27:1500–1510
  4. Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol. 2006;48:193–202
  5. Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200–2206
  6. Kim SW, Mintz GS, Hong YJ, et al. The virtual histology intravascular ultrasound appearance of newly placed drug-eluting stents. Am J Cardiol. 2008;102:1182–1186
  7. Klugherz BD, Llanos G, Lieuallen W, et al. Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stent. Coron Artery Dis. 2002;13:183–188
  8. Suzuki T, Kopia G, Hayashi S, et al. Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model. Circulation. 2001;104:1188–1193
  9. Carter AJ, Aggarwal M, Kopia GA, et al. Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res. 2004;63:617–624
  10. Finn AV, Kolodgie FD, Harnek J, et al. Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents. Circulation. 2005;112:270–278
  11. Nakazawa G, Finn AV, Joner M, et al. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. Circulation. 2008;118:1138–1145
  12. Levin AD, Vukmirovic N, Hwang CW, et al. Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Proc Natl Acad Sci USA. 2004;101:9463–9467
  13. Balakrishnan B, Tzafriri AR, Seifert P, et al. Strut position, blood flow, and drug deposition. Circulation. 2005;111:2958–2965
  14. Stone GW, Ellis SG, Cox DA, et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004;350:221–231
  15. Lerman A. Restenosis: another “dysfunction” of the endothelium. Circulation. 2005;111:8–10
  16. Rodriguez-Granillo GA, García-García HM, Mc Fadden EP, et al. In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol. 2005;46:2038–2042
  17. Burke AP, Farb A, Malcom GT, et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–1282

PII: S0002-8703(09)00880-1

doi: 10.1016/j.ahj.2009.11.008

American Heart Journal
Volume 159, Issue 2 , Pages 271-277 , February 2010

Article Tools

* Image Usage & Resolution