American Heart Journal
Volume 158, Issue 5 , Pages 755-760 , November 2009

Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial

  • Sorin J. Brener, MD

      Affiliations

    • New York Methodist Hospital, Brooklyn, NY
    • ,
  • Cynthia M. Westerhout, PhD

      Affiliations

    • University of Alberta, Edmonton, Canada
    • ,
  • Yuling Fu, MD

      Affiliations

    • University of Alberta, Edmonton, Canada
    • ,
  • Thomas G. Todaro, MD

      Affiliations

    • Medpace, Cincinnati, OH
    • ,
  • David J. Moliterno, MD

      Affiliations

    • University of Kentucky, Lexington, KY
    • ,
  • Galen S. Wagner, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • ,
  • Christopher B. Granger, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • ,
  • Paul W. Armstrong, MD

      Affiliations

    • University of Alberta, Edmonton, Canada
    • Corresponding Author InformationReprint requests: Paul W. Armstrong, MD, University of Alberta-Canadian VIGOUR Centre, 2-51 Medical Sciences Building, Edmonton, Canada AB T6G 2H7.
    • ,
  • for the APEX-AMI Investigators

Received 24 July 2009 ,Accepted 8 September 2009.

References 

  1. Boersma E. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J. 2006;27:779–788
  2. Buller CE, Fu Y, Mahaffey KW, et al. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation. 2008;118:1335–1346
  3. Brener SJ, Moliterno DJ, Aylward PE, et al. for the APEX-AMI Investigators Reperfusion after primary angioplasty for ST-elevation myocardial infarction: predictors of success and relationship to clinical outcomes in the APEX-AMI Angiographic Study. Eur Heart J. 2008;29:1127–1135
  4. APEX-AMI Investigators . Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronaryintervention: a randomized controlled trial. JAMA. 2007;297:43–51
  5. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med. 1985;312:932–936
  6. Gibson CM, Cannon CP, Murphy SA, et al. for the TIMI Study Group Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction. Circulation. 2002;105:1909–1913
  7. Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation. 2000;101:125–130
  8. Gibson CM, de Lemos JA, Murphy SA, et al. Methodologic and clinical validation of the TIMI myocardial perfusion grade in acute myocardial infarction. J Thromb Thrombol. 2002;14:233–237
  9. McLaughlin MG, Stone GW, Aymong E, et al. Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction: the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. J Am Coll Cardiol. 2004;44:1215–1223
  10. van 't Hof AW, Liem A, de Boer MJ, et al. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Zwolle Myocardial infarction Study Group. Lancet. 1997;350:615–619
  11. De Luca G, van 't Hof AW, De Boer MJ, et al. Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction treated by primary angioplasty. Eur Heart J. 2004;25:1009–1013
  12. Schroder R, Dissmann R, Bruggemann T, et al. Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol. 1994;24:384–391
  13. Schroder R, Wegscheider K, Schroder K, et al. for the INJECT Trial Group Extent of early ST segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens. A substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. J Am Coll Cardiol. 1995;26:1657–1664
  14. Matetzky S, Novikov M, Gruberg L, et al. The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. J Am Coll Cardiol. 1999;34:1932–1938
  15. Claeys MJ, Bosmans J, Veenstra L, et al. Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circ. 1999;99:1972–1977
  16. van 't Hof AW, Liem A, Suryapranata H, et al. on behalf of the ZWOLLE Myocardial Infarction Study Group Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group. Circulation. 1998;97:2302–2306
  17. Poli A, Fetiveau R, Vandoni P, et al. Integrated Analysis of Myocardial Blush and ST-Segment Elevation Recovery After Successful Primary Angioplasty: Real-Time Grading of Microvascular Reperfusion and Prediction of Early and Late Recovery of Left Ventricular Function. Circulation. 2002;106:313–318
  18. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction–Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation. 2004;110:588–636
  19. Steg PG, Goldberg RJ, Gore JM, et al. for the GRACE Investigators Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am J Cardiol. 2002;90:358–363

 Clinical trial registration information: http://www.clinicaltrials.gov. Unique identifier: NCT00091637.

 Morton J. Kern, MD seved as guest editor for this manuscript.

PII: S0002-8703(09)00726-1

doi: 10.1016/j.ahj.2009.09.009

American Heart Journal
Volume 158, Issue 5 , Pages 755-760 , November 2009

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