« Previous
Next »
American Heart Journal
Volume 158, Issue 5
, Pages 726-733
, November 2009
Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial
References
- Executive summary: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133:71S–109S
- ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention. Circulation. 2006;113:e166–e286
- Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial. Circulation. 2005;111:1390–1397
- Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA. 2003;289:853–863
- Enoxaparin vs unfractionated heparin in high-risk patients with non–ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA. 2004;292:45–54
- . Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med. 2006;354:1464–1476
- Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. N Engl J Med. 2008;359:688–696
- Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133:141S–159S
- Bivalirudin for patients with acute coronary syndromes. N Engl J Med. 2006;355:2203–2216
- Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218–2230
- ACC/AHA 2002 guideline update for the management of patients with unstable angina and non–ST-segment elevation myocardial infarction—summary article. J Am Coll Cardiol. 2002;40:1366–1374
- Efficacy of M118, a rationally engineered low-molecular-weight heparin, in a canine model of arterial thrombosis. In: Presented at ACC; 2007; New Orleans, LA. 2007;
- A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation. J Thromb Thrombolysis. 2009;28:132–139
- Safety, tolerability, pharmacokinetics and pharmacodynamics of M118, a novel, rationally engineered low-molecular-weight heparin given as a subcutaneous injection in a rising dose cohort regimen in healthy subjects. In: Presented at IXth World Conference on Clinical Pharmacology and Therapeutics; Quebec, Canada. 2008;
- Pharmacokinetic and pharmacodynamic properties of M118, a novel, rationally engineered low-molecular-weight heparin, following IV injection in human volunteers. In: Presented at American Society for Clinical Pharmacology and Therapeutics Annual Meeting; Orlando, FL. 2008;
- M118, a novel, rationally engineered low-molecular-weight heparin, with potent anti-xa and anti-IIa activities is reversible by protamine sulfate, and monitorable with act following multiple IV injections. In: Presented at American Society for Clinical Pharmacology and Therapeutics Annual Meeting; Washington, DC. 2009;
- Lack of drug-drug interactions with M118, a novel, rationally engineered low-molecular-weight heparin, when co-administered with multiple doses of aspirin and clopidogrel. In: Presented at IXth World Conference on Clinical Pharmacology and Therapeutics; Quebec, Canada. 2008;
- Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study. Circulation. 2005;111:2099–2106
- . Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial. Lancet. 2000;356:2037–2044
- Defining the optimal activated clotting time during percutaneous coronary intervention: aggregate results from 6 randomized, controlled trials. Circulation. 2001;103:961–966
- Relationship between heparin anticoagulation and clinical outcomes in coronary stent intervention: observations from the ESPRIT trial. J Am Coll Cardiol. 2003;41:386–393
- Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA. 2006;295:1519–1530
- . Molecular and cellular biology of blood coagulation. N Engl J Med. 1992;326:800–806
Gregory W. Barsness, MD, served as guest editor for this article.
PII: S0002-8703(09)00656-5
doi: 10.1016/j.ahj.2009.08.020
© 2009 Mosby, Inc. All rights reserved.
« Previous
Next »
American Heart Journal
Volume 158, Issue 5
, Pages 726-733
, November 2009
