American Heart Journal
Volume 158, Issue 4 , Pages 644-652 , October 2009

Characteristics and in-hospital outcomes for nonadherent patients with heart failure: Findings from Get With The Guidelines-Heart Failure (GWTG-HF)

  • Amrut V. Ambardekar, MD

      Affiliations

    • Denver Health Medical Center and University of Colorado Denver, Aurora, CO
    • Corresponding Author InformationReprint requests: Amrut V. Ambardekar MD, Division of Cardiology, University of Colorado Denver, 12631 E. 17th Avenue, Room 7102, Campus Box B-130, Aurora, CO 80045.
    • ,
  • Gregg C. Fonarow, MD

      Affiliations

    • Ahmanson-UCLA Cardiomyopathy Center, Los Angeles, CA
    • ,
  • Adrian F. Hernandez, MD, MS

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • ,
  • Wenqin Pan, PhD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • ,
  • Clyde W. Yancy, MD

      Affiliations

    • Baylor Heart and Vascular Institute, Dallas, TX
    • ,
  • Mori J. Krantz, MD

      Affiliations

    • Denver Health Medical Center and University of Colorado Denver, Aurora, CO
    • Colorado Prevention Center, Denver, CO
    • ,
  • for the Get With the Guidelines Steering Committee and Hospitals

Received 30 May 2009 ,Accepted 28 July 2009.

References 

  1. American Heart Association . Heart disease and stroke statistics—2006 update. Dallas (Tex): American Heart Association; 2006;
  2. Koelling TM, Chen RS, Lubwama RN, et al. The expanding national burden of heart failure in the United States: the influence of heart failure in women. Am Heart J. 2004;147:74–78
  3. Gheorghiade M, Zannad F, Sopko G, et al. International Working Group on Acute Heart Failure Syndromes. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005;112:3958–3968
  4. Adams KF, Lindenfeld J, Arnold JMO, et al. Executive summary: HFSA 2006 comprehensive heart failure practice guideline. J Cardiac Failure. 2006;12:10–38
  5. Krantz MJ, Havranek EP, Haynes DK, et al. Inpatient initiation of β-blockade plus nurse management in vulnerable heart failure patients: a randomized study. J Cardiac Fail. 2008;14:303–309
  6. Fonarow GC, Abraham WT, Albert NM, et al. Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). Am Heart J. 2007;153:82.e1–82.e11
  7. Hong Y, LaBresh KA. Overview of the American Heart Association “Get With The Guidelines” programs: Coronary heart disease, stroke, and heart failure. Crit Pathways in Cardiol. 2006;5:179–186
  8. The Joint Commission . Specification manual for national implementation of hospital core measures: version 2.5. Available at: http://www.jointcommission.org/PerformanceMeasurement/PerformanceMeasurement/Current+NHQM+Manual.htmLast accessed November 8, 2008
  9. Tsuyuki RT, McKelvie RS, Arnold MO, et al. Acute precipitants of congestive heart failure exacerbations. Arch Intern Med. 2001;161:2337–2342
  10. Granger BB, Swedbery K, Ikman I, et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomized, controlled clinical trial. Lancet. 2005;366:2005–2011
  11. Ghali JK, Kadakia S, Cooper R, et al. Precipitating factors leading to decompensation in heart failure: traits among urban blacks. Arch Intern Med. 1988;148:2013–2016
  12. Fonarow GC, Abraham WT, Albert NM, et al. Factors identified as precipitating hospital admission for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med. 2008;168:847–854
  13. Wu JR, Moser DK, Chung ML, et al. Objectively measured, but not self-reported, medication adherence independently predicts event-free survival in patients with heart failure. J Cardiac Failure. 2008;14:203–210
  14. Fonarow GC, Abraham WT, Albert NM, et al. Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA. 2007;297:61–70
  15. Fonarow GC, Yancy CW, Heywood J. Adherence to Heart Failure Quality of Care Indicators in US hospitals: Analysis of the ADHERE Registry. Arch Intern Med. 2005;165:1469–1477
  16. Roe MT. Success stories: how hospitals are improving care. Am Heart J. 2004;148:S52–S55
  17. Ahmed A, Allman RM, Kiefe CI, et al. Association of consultation between generalists and cardiologists with quality and outcomes of heart failure care. Am Heart J. 2003;145:1086–1093

 Dr. Hernandez received American Heart Association Pharmaceutical Roundtable grant 0675060N.

 Jack V. Tu, MD, PhD served as guest editor on this manuscript.

PII: S0002-8703(09)00613-9

doi: 10.1016/j.ahj.2009.07.034

American Heart Journal
Volume 158, Issue 4 , Pages 644-652 , October 2009

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