American Heart Journal
Volume 158, Issue 4 , Pages 673-679 , October 2009

Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: Data from The Heart and Soul Study

  • Bill P.C. Hsieh, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA
    • Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, San Francisco, CA
    • Corresponding Author InformationReprint requests: Bill P. C. Hsieh, MD, Heart and Soul Study, 4150 Clement St (111A1), San Francisco, CA 94121.
    • ,
  • Adam M. Rogers, MD

      Affiliations

    • Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, San Francisco, CA
    • ,
  • Beeya Na, MPH

      Affiliations

    • Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, San Francisco, CA
    • ,
  • Alan H.B. Wu

      Affiliations

    • Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
    • ,
  • Nelson B. Schiller, MD, FACC

      Affiliations

    • Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA
    • Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, San Francisco, CA
    • ,
  • Mary A. Whooley, MD

      Affiliations

    • Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, San Francisco, CA

Received 9 November 2008 ,Accepted 10 July 2009.

References 

  1. Antman EM, Tanasijevic MJ, Thompson B, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med. 1996;335:1342–1349
  2. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation. 2007;116:2634–2653
  3. Goodman SG, Steg PG, Eagle KA, et al. The diagnostic and prognostic impact of the redefinition of acute myocardial infarction: lessons from the Global Registry of Acute Coronary Events (GRACE). Am Heart J. 2006;151:654–660
  4. Wallace TW, Abdullah SM, Drazner MH, et al. Prevalence and determinants of troponin T elevation in the general population. Circulation. 2006;113:1958–1965
  5. Zethelius B, Johnston N, Venge P. Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study. Circulation. 2006;113:1071–1078
  6. Latini R, Masson S, Anand IS, et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation. 2007;116:1242–1249
  7. Khan NA, Hemmelgarn BR, Tonelli M, et al. Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis. Circulation. 2005;112:3088–3096
  8. Bibbins-Domingo K, Gupta R, Na B, et al. N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease. Jama. 2007;297:169–176
  9. Troponin T STAT (short turn around time), cardiac T. Elecsys (package insert). 2004;V9:1–5
  10. Alpert JS, Thygesen K, Antman E, et al. Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  11. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2:358–367
  12. Venge P, Lagerqvist B, Diderholm E, et al. Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy). Am J Cardiol. 2002;89:1035–1041
  13. Peacock WFt, De Marco T, Fonarow GC, et al. Cardiac troponin and outcome in acute heart failure. N Engl J Med. 2008;358:2117–2126
  14. Missov E, Calzolari C, Pau B. Circulating cardiac troponin I in severe congestive heart failure. Circulation. 1997;96:2953–2958
  15. La Vecchia L, Mezzena G, Ometto R, et al. Detectable serum troponin I in patients with heart failure of nonmyocardial ischemic origin. Am J Cardiol. 1997;80:88–90
  16. Logeart D, Beyne P, Cusson C, et al. Evidence of cardiac myolysis in severe nonischemic heart failure and the potential role of increased wall strain. Am Heart J. 2001;141:247–253
  17. Longenecker JC, Coresh J, Powe NR, et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study. J Am Soc Nephrol. 2002;13:1918–1927
  18. Diris JH, Hackeng CM, Kooman JP, et al. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. Circulation. 2004;109:23–25
  19. Apple FS, Parvin CA, Buechler KF, et al. Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction. Clin Chem. 2005;51:2198–2200

PII: S0002-8703(09)00548-1

doi: 10.1016/j.ahj.2009.07.021

American Heart Journal
Volume 158, Issue 4 , Pages 673-679 , October 2009

Article Tools

* Image Usage & Resolution