American Heart Journal
Volume 158, Issue 3 , Pages 386-391 , September 2009

Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: Observations from the PROTECT-TIMI 30 Trial

  • Sean R. Wilson, MD

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • ,
  • Marc S. Sabatine, MD, MPH

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • Cardiovascular Division, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • ,
  • Eugene Braunwald, MD

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • Cardiovascular Division, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • ,
  • Sarah Sloan, MA, MS

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • ,
  • Sabina A. Murphy, MPH

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • ,
  • David A. Morrow, MD, MPH

      Affiliations

    • TIMI Study Group, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • Cardiovascular Division, Brigham and Women's Hospital and Department of Medicine, Boston, MA
    • Corresponding Author InformationReprint requests: David A. Morrow, MD, MPH, TIMI Study Group/Cardiovascular Division Brigham and Women's Hospital 75 Francis Street Boston, MA 02115.

Received 24 November 2008 ,Accepted 5 June 2009.

References 

  1. The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  2. Jaffe AS, Ravkilde J, Roberts R, et al. It's time for a change to a troponin standard. Circulation. 2000;102:1216–1220
  3. Morrow DA, Cannon CP, Jesse RL, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes. Circulation. 2007;115:e356–e375
  4. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Eur Heart J. 2007;28:2525–2538
  5. Morrow DA, Cannon CP, Rifai N, et al. Ability of minor elevations of troponin I and T to identify patients with unstable angina and non-ST elevation myocardial infarction who benefit from an early invasive strategy: Results from a prospective, randomized trial. JAMA. 2001;286:2405–2412
  6. James S, Armstrong P, Califf R, et al. Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial. Am J Med. 2003;115:178–184
  7. Morrow DA, de Lemos JA, Sabatine MS, et al. The search for a biomarker of cardiac ischemia. Clin Chem. 2003;49:537–539
  8. Apple FS, Jesse RL, Newby LK, et al. National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes. Clin Chem. 2007;53:547–551
  9. Jaffe AS, Babuin L, Apple FS. Biomarkers in acute cardiac disease: the present and the future. J Am Coll Cardiol. 2006;48:1–11
  10. Gibson CM, Morrow DA, Murphy SA, et al. A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. J Am Coll Cardiol. 2006;47:2364–2373
  11. Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007;50:e1–e157
  12. Panteghini M, Pagani F, Yeo KT, et al. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem. 2004;50:327–332
  13. Morrow DA, Antman EM, Tanasijevic M, et al. Cardiac troponin I for stratification of early outcomes and the efficacy of enoxaparin in unstable angina: a TIMI 11B substudy. J Am Coll Cardiol. 2000;36:1812–1817
  14. Apple FS, Murakami M, Hollander JE, et al. Preliminary Performance of a High Sensitive Gold Nanoparticle-Based Cardiac Troponin I Assay: Proof-of-Concept Study of the Nanosphere Verigene System. [in review] 2008.
  15. Venge P, Lindahl B, Wallentin L. New generation cardiac troponin I assay for the access immunoassay system. Clin Chem. 2001;47:959–961
  16. Morrow DA, Rifai N, Sabatine MS, et al. Evaluation of the AccuTnI cardiac troponin I assay for risk assessment in acute coronary syndromes. Clin Chem. 2003;49:1396–1398
  17. Eggers KM, Lagerqvist B, Venge P, et al. Persistent Cardiac Troponin I Elevation in Stabilized Patients After an Episode of Acute Coronary Syndrome Predicts Long-Term Mortality. Circulation. 2007;116:1907–1914
  18. Sabatine MS, Morrow DA, Lu QA, et al. Detection of Acute Changes in Circulating Troponin in the Setting of Transient Stress Test-Induced Myocardial Ischemia Using an Ultrasensitive Assay: Results from TIMI 35. Eur Heart J. 2009;30:162–169
  19. Latini R, Masson S, Anand IS, et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation. 2007;116:1242–1249
  20. Wallace TW, Abdullah SM, Drazner MH, et al. Prevalence and determinants of troponin T elevation in the general population. Circulation. 2006;113:1958–1965
  21. Morrow DA, Antman EM. Evaluation of high-sensitivity assays for cardiac troponin. Clin Chem. 2009;55:5–8
  22. Jaffe AS. Elevations in cardiac troponin measurements: false false-positives: the real truth. Cardiovasc Toxicol. 2001;1:87–92
  23. Katus HA, Remppis A, Scheffold T, et al. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am J Cardiol. 1991;67:1360–1367
  24. Christenson RH, Duh SH, Apple FS, et al. Toward standardization of cardiac troponin I measurements part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays. Clin Chem. 2006;52:1685–1692

 Clinical trial registration: ClinicalTrials.gov no. NCT00250471.

PII: S0002-8703(09)00453-0

doi: 10.1016/j.ahj.2009.06.011

American Heart Journal
Volume 158, Issue 3 , Pages 386-391 , September 2009

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