American Heart Journal
Volume 158, Issue 3 , Pages e27-e34 , September 2009

Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy

  • Vy-Van Le, MD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA
    • Department of Cardiology, VAPAHCS, Palo Alto, CA
    • Corresponding Author InformationReprint requests: Vy-Van Le, MD, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Drive Stanford, CA 94305.
  • ,
  • Marco V. Perez, MD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA
  • ,
  • Matthew T. Wheeler, MD, PhD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA
  • ,
  • Jonathan Myers, PhD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA
    • Department of Cardiology, VAPAHCS, Palo Alto, CA
  • ,
  • Ingela Schnittger, MD

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA
  • ,
  • Euan A. Ashley, MRCP, DPhil

      Affiliations

    • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA

Received 13 March 2009 ,Accepted 5 June 2009.

  • Image Result

    Morphology classification. A, proximal, B, reverse curvature, C, apical, D, concentric HCM.

    Morphology classification. A, proximal, B, reverse curvature, C, apical, D, concentric HCM.

  • Image Result

    Univariate correlations between peak Vo2 and A, Lateral E′, B, Indexed LA volume, C, Rest and, D, Exercise LVOT gradients.

    Univariate correlations between peak Vo2 and A, Lateral E′, B, Indexed LA volume, C, Rest and, D, Exercise LVOT gradients.

  • Image Result

    Plots of A) maximal exercise capacity and B) %predicted maximal Vo2 by patterns.

    Plots of A) maximal exercise capacity and B) %predicted maximal Vo2 by patterns.

PII: S0002-8703(09)00448-7

doi: 10.1016/j.ahj.2009.06.006

American Heart Journal
Volume 158, Issue 3 , Pages e27-e34 , September 2009