Do the association of cytochrome P450 interacting drugs, influence clopidogrel efficacity?
Refers to article:
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel
, 07 November 2008
Jolanta M. Siller-Matula, Alexander O. Spiel, Irene M. Lang, Gerhard Kreiner, Guenter Christ, Bernd Jilma
American Heart Journal
January 2009 (Vol. 157, Issue 1, Pages 148.e1-148.e5) Abstract |
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In their article “Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel,” Siller-Matula et al state that “results were not affected by the intake of statin.”1
Whether or not statin are metabolized through the cytochrome P450 3A4 system has no impact on clopidogrel efficacity.2, 3
But may we have to fear a negative effect from the association of cytochrome interacting drugs?
Hence, can the author say more precisely if their results were also not affected by the intake of statins that are metabolized through the cytochrome P450 3A4 system, such as atorvastatin and simvastatin?
References
1. 1Siller-Matula JM, Spiel AO, Lang IM, et al.Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel.. Am Heart J. 2009;157:148.e1–148.e5. Abstract | Full Text |
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2. 2Lotfi A, Schweiger MJ, Giugliano GR, et al.TIMI 22 Investigators. High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients—a Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis. Am Heart J. 2008;155:954–958[Electronic publication]. Abstract | Full Text |
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3. 3Jacqueline S, Danielle M, Brennan MS, et al.Lack of evidence of a clopidogrel-statin interaction in the CHARISMA Trial.. J Am Coll Cardiol. 2007;50:291–295. Abstract | Full Text |
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Institut Arnault Tzanck, Saint Laurent du Var, France
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