American Heart Journal
Volume 157, Issue 5 , Pages 889-893 , May 2009

Aspirin noncompliance is the major cause of “aspirin resistance” in patients undergoing coronary stenting

  • Thomas Cuisset, MD

      Affiliations

    • Department of Cardiology, CHU Timone, Marseille, France
    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
    • Corresponding Author InformationReprint requests: Thomas Cuisset, MD, Department of Cardiology, CHU Timone, 69 rue perrin solliers, 13006 Marseille, France.
  • ,
  • Corinne Frere, MD, PhD

      Affiliations

    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
  • ,
  • Jacques Quilici, MD

      Affiliations

    • Department of Cardiology, CHU Timone, Marseille, France
  • ,
  • Bénédicte Gaborit, MD

      Affiliations

    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
  • ,
  • Laurent Bali, MD

      Affiliations

    • Department of Cardiology, CHU Timone, Marseille, France
  • ,
  • Raphaël Poyet, MD

      Affiliations

    • Department of Cardiology, CHU Timone, Marseille, France
  • ,
  • Dorothée Faille, MD

      Affiliations

    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
  • ,
  • Pierre Emmanuel Morange, MD, PhD

      Affiliations

    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
  • ,
  • Marie-Christine Alessi, MD, PhD

      Affiliations

    • Inserm, U626, Faculté de Médecine, Marseille, France
    • Laboratoire d'Hématologie, CHU Timone, Marseille, France
  • ,
  • Jean-Louis Bonnet, MD

      Affiliations

    • Department of Cardiology, CHU Timone, Marseille, France

Received 6 October 2008 ,Accepted 19 February 2009.

References 

  1. Yusuf S, Zhao F, Mehta SR, et al. Clopidogrel in Unstable angina to prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502
  2. Mehta SR, Yusuf S, Peters RJ, et al. Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527–533
  3. Sanderson S, Emery J, Baglin T, et al. Narrative review: aspirin resistance and its clinical implications. Ann Intern Med. 2005;142:370–380
  4. Eikelboom JW, Hirsh J, Weitz JI, et al. Aspirin resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation. 2002;105:1650–1655
  5. Gum PA, Kottke-Marchant K, Welsh PA, et al. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol. 2003;41:961–965
  6. Chen WH, Lee PY, Ng W, et al. Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment. J Am Coll Cardiol. 2004;43:1122–1126
  7. Cuisset T, Frere C, Quilici J, et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006;4:542–549
  8. Gori AM, Marcucci R, Migliorini A, et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents. J Am Coll Cardiol. 2008;52:734–739
  9. Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin “resistance” and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ. 2008;336:195–210
  10. Schwartz KA, Schwartz DE, Ghosheh K, et al. Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction. Am J Cardiol. 2005;95:973–975
  11. Horwitz RI, Viscoli CM, Berkman L, et al. Treatment adherence and risk of death after a myocardial infarction. Lancet. 1990;336:542–545
  12. Gallagher EJ, Viscoli CM, Horwitz RI. The relationship of treatment adherence to the risk of death after myocardial infarction in women. JAMA. 1993;270:742–744
  13. Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA. 2005;293:2126–2130
  14. Collet JP, Montalescot G, Blanchet B, et al. Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes. Circulation. 2004;110:2361–2367

PII: S0002-8703(09)00145-8

doi: 10.1016/j.ahj.2009.02.013

American Heart Journal
Volume 157, Issue 5 , Pages 889-893 , May 2009