American Heart Journal
Volume 157, Issue 5 , Pages 908-912 , May 2009

Vitamin K epoxide reductase complex subunit 1 gene polymorphism is associated with atherothrombotic complication after drug-eluting stent implantation: 2-Center prospective cohort study

  • Jung-Won Suh, MD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • Sang-Hong Baek, MD, PhD

      Affiliations

    • Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, South Korea
    • Corresponding Author InformationReprint requests: Hyo-Soo Kim, MD, PhD and Sang-Hong Baek, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, South Korea.
    • ,
  • Jin-Shik Park, MD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • Hyun-Jae Kang, MD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • In-Ho Chae, MD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • Dong-Ju Choi, MD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • Hun-Jun Park, MD

      Affiliations

    • Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, South Korea
    • ,
  • Pum-Joon Kim, MD

      Affiliations

    • Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, South Korea
    • ,
  • Ki-Bae Seung, MD

      Affiliations

    • Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, South Korea
    • ,
  • Hyo-Soo Kim, MD, PhD

      Affiliations

    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    • Corresponding Author InformationReprint requests: Hyo-Soo Kim, MD, PhD and Sang-Hong Baek, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, South Korea.

Received 4 August 2008 ,Accepted 1 February 2009.

References 

  1. Taubman MB, Fallon JT, Schecter AD, et al. Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost. 1997;78:200–204
  2. Lima LM, Sousa MO, Dusse LM, et al. Tissue factor and tissue factor pathway inhibitor levels in coronary artery disease: correlation with the severity of atheromatosis. Thromb Res. 2007;121:283–287
  3. Tutar E, Ozcan M, Kilickap M, et al. Elevated whole-blood tissue factor procoagulant activity as a marker of restenosis after percutaneous transluminal coronary angioplasty and stent implantation. Circulation. 2003;108:1581–1584
  4. Palmerini T, Coller BS, Cervi V, et al. Monocyte-derived tissue factor contributes to stent thrombosis in an in vitro system. J Am Coll Cardiol. 2004;44:1500–1507
  5. Moons AH, Levi M, Peters RJ. Tissue factor and coronary artery disease. Cardiovasc Res. 2002;53:313–325
  6. Spronk HM. Vitamin K epoxide reductase complex and vascular calcifications: is this the important link between vitamin K and the arterial vessel wall?. Circulation. 2006;113:1550–1552
  7. Oldenburg J, Watzka M, Rost S, et al. VKORC1: molecular target of coumarins. J Thromb Haemost. 2007;5(Suppl 1):1–6
  8. D'Andrea G, D'Ambrosio RL, Di Perna P, et al. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood. 2005;105:645–649
  9. Rieder MJ, Reiner AP, Gage BF, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Eng J Med. 2005;352:2285–2293
  10. Schwarz UI, Ritchie MD, Bradford Y, et al. Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med. 2008;358:999–1008
  11. Wang Y, Zhang W, Zhang Y, et al. VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation. 2006;113:1615–1621
  12. Teichert M, Visser LE, van Schaik RH, et al. Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification. The Rotterdam Study. Arterioscler Thromb Vasc Biol. 2008;28:771–776
  13. Syvänen AC. Toward genome-wide SNP genotyping. Nat Genet. 2005;37:S5–S10
  14. Gunderson KL, Steemers FJ, Lee G, et al. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet. 2005;37:549–554
  15. Braunwald E, Antman E, Beasley J, et al. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non–ST-segment elevation myocardial infarction: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). Circulation. 2002;106:1893–1900
  16. Cutlip DE, Windecker S, Mehran R, et al. Clinical end points in coronary stent trials. Circulation. 2007;115:2344–2351
  17. Hindorff LA, Heckbert SR, Smith N, et al. Common VKORC1 variants are not associated with arterial or venous thrombosis. J Thormb Haemost. 2007;5:2025–2027
  18. Steffel J, Luscher TF, Tanner FC. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation. 2006;113:722–731
  19. Steffel J, Latini RA, Akhmedov A, et al. Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design. Circulation. 2005;112:2002–2011
  20. Stähli BE, Camici GG, Steffel J, et al. Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-Jun terminal NH2 kinase activation. Cir Res. 2006;99:149–155
  21. Lüscher TF, Steffel J, Eberli FR, et al. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115:1051–1058

 This study was supported by the grants from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0412-CR02-0704-0001), and the Innovative Research Institute for Cell Therapy (A062260).

PII: S0002-8703(09)00102-1

doi: 10.1016/j.ahj.2009.02.001

American Heart Journal
Volume 157, Issue 5 , Pages 908-912 , May 2009

Article Tools

* Image Usage & Resolution