American Heart Journal
Volume 157, Issue 3 , Pages 488-494.e1 , March 2009

Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: Rationale and design

  • Paul S. Myles, MPH, MD

      Affiliations

    • Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • Academic Board of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia
    • Department of Epidemiology and Preventive Medicine, Monash University; Melbourne, Victoria, Australia
    • Australian National Health and Medical Research Council Centre for Clinical Research Excellence in Therapeutics, Melbourne, Victoria, Australia
    • Corresponding Author InformationReprint requests: Paul S. Myles, MPH, MD, Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia.
    • ,
  • Kate Leslie, MEpi, MD

      Affiliations

    • Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    • ,
  • Philip Peyton, MBBS, MD

      Affiliations

    • Department of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australia
    • ,
  • Michael Paech, MB.BS, DM

      Affiliations

    • The School of Medicine and Pharmacology, The University of Western Australia, Perth, WA, Australia
    • ,
  • Andrew Forbes, MSc, PhD

      Affiliations

    • Department of Epidemiology and Preventive Medicine, Monash University; Melbourne, Victoria, Australia
    • ,
  • Matthew T.V. Chan, MB.BS, FANZCA

      Affiliations

    • Department of Anaesthesia, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    • ,
  • Daniel Sessler, MD

      Affiliations

    • Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH
    • ,
  • Philip J. Devereaux, MD, PhD

      Affiliations

    • Departments of Clinical Epidemiology and Biostatististics and Medicine, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Brendan S. Silbert, MBBS, FANZCA

      Affiliations

    • Department of Anaesthesia, St Vincent's Hospital, Fitzroy, Victoria, Australia
    • ,
  • Konrad Jamrozik, MB.BS, DPhil

      Affiliations

    • School of Population Health & Clinical Practice, University of Adelaide, SA, Australia
    • ,
  • Scott Beattie, MD, PhD

      Affiliations

    • Department of Anaesthesia, University Health Network, Toronto, Ontario, Canada
    • ,
  • Neal Badner, MD, FRCP(C)

      Affiliations

    • Department of Anesthesiology, University of Western Ontario, London, Ontario, Canada
    • ,
  • James Tomlinson, MB.BS, FRACP

      Affiliations

    • Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • Academic Board of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia
    • ,
  • Sophia Wallace, BSc

      Affiliations

    • Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    • ,
  • the ANZCA Trials Group

Received 30 September 2008 ,Accepted 25 November 2008.

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 Trial Registration: www.clinicaltrials.gov CT00430989.

 For ENIGMA-II Trial Organization and a list of committees see Appendix A, available online.

PII: S0002-8703(08)01038-7

doi: 10.1016/j.ahj.2008.11.015

American Heart Journal
Volume 157, Issue 3 , Pages 488-494.e1 , March 2009

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