American Heart Journal
Volume 157, Issue 3 , Pages 541-547 , March 2009

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: Results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac Magnetic Resonance Imaging substudy

  • Thorsten Dill, MD

      Affiliations

    • Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    • Corresponding Author InformationReprint requests: Thorsten Dill, MD, Department of Cardiology, Kerckhoff Heart Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany.
    • ,
  • Volker Schächinger, MD

      Affiliations

    • Department of Cardiology, University Hospital, Frankfurt, Germany
    • ,
  • Andreas Rolf, MD

      Affiliations

    • Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    • ,
  • Susanne Möllmann, MD

      Affiliations

    • Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    • ,
  • Holger Thiele, MD

      Affiliations

    • Department of Cardiology, Leipzig Heart Center, Leipzig, Germany
    • ,
  • Harald Tillmanns, MD

      Affiliations

    • Department of Cardiology, University Hospital, Giessen, Germany
    • ,
  • Birgit Assmus, MD

      Affiliations

    • Department of Cardiology, University Hospital, Frankfurt, Germany
    • ,
  • Stefanie Dimmeler, PhD

      Affiliations

    • Department of Cardiology, University Hospital, Frankfurt, Germany
    • ,
  • Andreas M. Zeiher, MD

      Affiliations

    • Department of Cardiology, University Hospital, Frankfurt, Germany
    • ,
  • Christian Hamm, MD

      Affiliations

    • Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany

Received 17 April 2008 ,Accepted 14 November 2008.

References 

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  12. Schaechinger V, Erbs S, Elsaesser A, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR AMI trial. Eur Heart J. 2006;27:2775–2783
  13. Fuster V, Sanz J, Viles-Gonzalez JF, et al. The utility of magnetic resonance imaging in cardiac tissue regeneration trials. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S2–S7
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  15. Meyer GP, Wollert KC, Lotz J, et al. Eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) Trial. Circulation. 2006;113:1287–1294
  16. Schaechinger V, Tonn T, Dimmeler S, et al. Bone-marrow-derived progenitor cell therapy in need of proof of concept: design of the REPAIR-AMI trial. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S23–S28
  17. Gaudron P, Eilles C, Kugler I, et al. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation. 1993;87:755–763
  18. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161–1172
  19. Warren SE, Royal HD, Markis JE, et al. Time course of left ventricular dilation after myocardial infarction: influence of infarct-related artery and success of coronary thrombolysis. J Am Coll Cardiol. 1988;11:12–19
  20. Halkin A, Singh M, Nikolsky E, et al. Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: the CADILLAC risk score. J Am Coll Cardiol. 2005;45:1397–1405
  21. Choi CJ, Haji-Momenian S, Dimaria JM, et al. Infarct involution and improved function during healing of acute myocardial infarction: the role of microvascular infarction. J Cardiovasc Magn Reson. 2004;6:917–925
  22. Hombach V, Grebe O, Merkle N, et al. Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging. Eur Heart J. 2005;26:549–557
  23. Penn MS. Stem-cell therapy after acute myocardial infarction: the focus should be on those at risk. Lancet. 2006;367:87–88

 Clinical trial registration: NCT00279175.

PII: S0002-8703(08)01029-6

doi: 10.1016/j.ahj.2008.11.011

American Heart Journal
Volume 157, Issue 3 , Pages 541-547 , March 2009

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