American Heart Journal
Volume 157, Issue 3 , Pages 576-583 , March 2009

N-acetylcysteine versus AScorbic acid for Preventing contrast-Induced nephropathy in patients with renal insufficiency undergoing coronary angiography: NASPI study—a prospective randomized controlled trial

  • Sang-Ho Jo, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Gyeonggi-do, Korea
    • The affiliation of the first author has changed from Seoul National University Hospital to Hallym University Sacred Heart Hospital since this work was completed.
    • ,
  • Bon-Kwon Koo, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • Corresponding Author InformationReprint requests: Hyo-Soo Kim, MD, PhD or Bon-Kwon Koo, MD, PhD, Department of Internal Medicine, Seoul National University/Cardiovascular Center, Seoul National University Hospital; National Research Laboratory for Cardiovascular Stem Cell, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Korea.
    • ,
  • Jin-Shik Park, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Hyun-Jae Kang, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Yong-Jin Kim, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Hack-Lyoung Kim, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • In-Ho Chae, MD

      Affiliations

    • Cardiovascular Center, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
    • ,
  • Dong-Ju Choi, MD

      Affiliations

    • Cardiovascular Center, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
    • ,
  • Dae-Won Sohn, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Byung-Hee Oh, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Young-Bae Park, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Yun-Shik Choi, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • ,
  • Hyo-Soo Kim, MD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    • Corresponding Author InformationReprint requests: Hyo-Soo Kim, MD, PhD or Bon-Kwon Koo, MD, PhD, Department of Internal Medicine, Seoul National University/Cardiovascular Center, Seoul National University Hospital; National Research Laboratory for Cardiovascular Stem Cell, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Korea.

Received 23 September 2008 ,Accepted 14 November 2008.

References 

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  14. Jo SH, Youn TJ, Koo BK, et al. Renal toxicity evaluation and comparison between Visipaque (iodixanol) and Hexabrix (ioxaglate) in patients with renal insufficiency undergoing coronary angiography: the RECOVER study: a randomized controlled trial. J Am Coll Cardiol. 2006;48:924–930
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  19. Solomon R, Werner C, Mann D, et al. Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents. N Engl J Med. 1994;331:1416–1420
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  23. Ozcan EE, Guneri S, Akdeniz B, et al. Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 2007;154:539–544

 Clinical Trial Identifier: NCT00356954.

 This study was supported by a grant from the Innovative Research Institute for Cell Therapy (IRICT: A062260), Republic of Korea, and Clinical Research Center for Ischemic Heart Disease sponsored by the Ministry of Health and Welfare, Republic of Korea (0412-CR02-0704-0001).

PII: S0002-8703(08)01028-4

doi: 10.1016/j.ahj.2008.11.010

American Heart Journal
Volume 157, Issue 3 , Pages 576-583 , March 2009

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