American Heart Journal
Volume 157, Issue 3 , Pages 563-568 , March 2009

Adverse association between diabetic retinopathy and cardiac structure and function

  • David Aguilar, MD

      Affiliations

    • Winters Center for Heart Failure Research and Section of Cardiology, Baylor College of Medicine, Houston, TX
    • Corresponding Author InformationReprint requests: David Aguilar, MD, Cardiovascular Division; Baylor College of Medicine, 1709 Dryden Street, Suite 9.39, MS: BCM 620, Houston, TX 77030.
    • ,
  • D. Michael Hallman, PhD

      Affiliations

    • Human Genetics Center, the University of Texas Health Science Center School of Public Health, Houston, TX
    • ,
  • Linda B. Piller, MD, MPH

      Affiliations

    • Human Genetics Center, the University of Texas Health Science Center School of Public Health, Houston, TX
    • ,
  • Barbara E.K. Klein, MD

      Affiliations

    • University of Wisconsin School of Medicine and Public Health, Madison, WI
    • ,
  • Ronald Klein, MD, MPH

      Affiliations

    • University of Wisconsin School of Medicine and Public Health, Madison, WI
    • ,
  • Richard B. Devereux, MD

      Affiliations

    • Weill Cornell Medical College, New York, NY
    • ,
  • Donna K. Arnett, PhD

      Affiliations

    • University of Alabama at Birmingham, AL
    • ,
  • Victor H. Gonzalez, MD

      Affiliations

    • Valley Retina Institute, McAllen, TX
    • ,
  • Craig L. Hanis, PhD

      Affiliations

    • Human Genetics Center, the University of Texas Health Science Center School of Public Health, Houston, TX

Received 6 August 2008 ,Accepted 26 October 2008.

References 

  1. He J, Ogden LG, Bazzano LA, et al. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001;161:996–1002
  2. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241:2035–2038
  3. Nichols GA, Gullion CM, Koro CE, et al. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care. 2004;27:1879–1884
  4. Devereux RB, Roman MJ, Paranicas M, et al. Impact of diabetes on cardiac structure and function: the strong heart study. Circulation. 2000;101:2271–2276
  5. Galderisi M, Anderson KM, Wilson PW, et al. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol. 1991;68:85–89
  6. Palmieri V, Bella JN, Arnett DK, et al. Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study. Circulation. 2001;103:102–107
  7. Rutter MK, Parise H, Benjamin EJ, et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation. 2003;107:448–454
  8. Bertoni AG, Hundley WG, Massing MW, et al. Heart failure prevalence, incidence, and mortality in the elderly with diabetes. Diabetes Care. 2004;27:699–703
  9. De Groote P, Lamblin N, Mouquet F, et al. Impact of diabetes mellitus on long-term survival in patients with congestive heart failure. Eur Heart J. 2004;25:656–662
  10. Pocock SJ, Wang D, Pfeffer MA, et al. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J. 2006;27:65–75
  11. From AM, Leibson CL, Bursi F, et al. Diabetes in heart failure: prevalence and impact on outcome in the population. Am J Med. 2006;119:591–599
  12. Wong TY, Rosamond W, Chang PP, et al. Retinopathy and risk of congestive heart failure. JAMA. 2005;293:63–69
  13. Cheung N, Wang JJ, Rogers SL, et al. Diabetic retinopathy and risk of heart failure. J Am Coll Cardiol. 2008;51:1573–1578
  14. Brown SA, Becker HA, Garcia AA, et al. Measuring health beliefs in Spanish-speaking Mexican Americans with type 2 diabetes: adapting an existing instrument. Res Nurs Health. 2002;25:145–158
  15. FBPP Investigators . Multi-center genetic study of hypertension: the Family Blood Pressure Program (FBPP). Hypertension. 2002;39:3–9
  16. Grading diabetic retinopathy from stereoscopic color fundus photographs—an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98(5 Suppl):786–806
  17. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–1463
  18. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  19. Teichholz LE, Kreulen T, Herman MV, et al. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976;37:7–11
  20. Devereux RB, Roman MJ, Paranicas M, et al. Relations of Doppler stroke volume and its components to left ventricular stroke volume in normotensive and hypertensive American Indians: the Strong Heart Study. Am J Hypertens. 1997;10:619–628
  21. Devereux RB, de Simone G, Pickering TG, et al. Relation of left ventricular midwall function to cardiovascular risk factors and arterial structure and function. Hypertension. 1998;31:929–936
  22. de Simone G, Roman MJ, Koren MJ, et al. Stroke volume/pulse pressure ratio and cardiovascular risk in arterial hypertension. Hypertension. 1999;33:800–805
  23. Cheung N, Wang JJ, Klein R, et al. Diabetic retinopathy and the risk of coronary heart disease: the Atherosclerosis Risk in Communities Study. Diabetes Care. 2007;30:1742–1746
  24. Juutilainen A, Lehto S, Ronnemaa T, et al. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women. Diabetes Care. 2007;30:292–299
  25. Cheung N, Bluemke DA, Klein R, et al. Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis. J Am Coll Cardiol. 2007;50:48–55
  26. Ogawa O, Hayashi C, Nakaniwa T, et al. Arterial stiffness is associated with diabetic retinopathy in type 2 diabetes. Diabetes Res Clin Pract. 2005;68:162–166
  27. Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?. Circulation. 2002;106:2085–2090
  28. Kawaguchi M, Hay I, Fetics B, et al. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation. 2003;107:714–720
  29. Annonu AK, Fattah AA, Mokhtar MS, et al. Left ventricular systolic and diastolic functional abnormalities in asymptomatic patients with non–insulin-dependent diabetes mellitus. J Am Soc Echocardiogr. 2001;14:885–891
  30. Quinones MA. Assessment of diastolic function. Prog Cardiovasc Dis. 2005;47:340–355
  31. Pritchett AM, Mahoney DW, Jacobsen SJ, et al. Diastolic dysfunction and left atrial volume: a population-based study. J Am Coll Cardiol. 2005;45:87–92
  32. Devereux RB, Alderman MH. Role of preclinical cardiovascular disease in the evolution from risk factor exposure to development of morbid events. Circulation. 1993;88:1444–1455
  33. Kizer JR, Bella JN, Palmieri V, et al. Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS). Am Heart J. 2006;151:412–418
  34. Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–1566

 This study was supported in part by the National Heart, Lung, and Blood Institute Family Blood Pressure Program (HL54504), the National Eye Institute (EY12386), and an NIH Mentored Clinical Investigator Award (5K12RR017665-05) to Dr Aguilar.

PII: S0002-8703(08)00910-1

doi: 10.1016/j.ahj.2008.10.019

American Heart Journal
Volume 157, Issue 3 , Pages 563-568 , March 2009

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