American Heart Journal
Volume 157, Issue 3 , Pages 467-473.e1 , March 2009

National time trends in congenital heart defects, Denmark, 1977-2005

  • Nina Øyen, MD, DrMed

      Affiliations

    • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    • Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    • Department of Public Health and Primary Healthcare, University of Bergen, Bergen, Norway
    • Corresponding Author InformationReprint requests: Nina Øyen, MD, DrMed, Department Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
  • ,
  • Gry Poulsen, MSc

      Affiliations

    • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Heather A. Boyd, PhD

      Affiliations

    • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Jan Wohlfahrt, MSc, DrMed

      Affiliations

    • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Peter K.A. Jensen, MD, DrMed

      Affiliations

    • Department of Clinical Genetics, Århus University Hospital, Århus, Denmark
  • ,
  • Mads Melbye, MD, DrMed

      Affiliations

    • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Received 22 September 2008 ,Accepted 23 October 2008.

References 

  1. Mitchell SC, Korones SB, Berendes HW. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation. 1971;43:323–332
  2. Smeeton NC, Rona RJ, Sharland G, et al. Estimating the prevalence of malformation of the heart in the first year of life using capture-recapture methods. Am J Epidemiol. 1999;150:778–785
  3. Wren C. Temporal variability in birth prevalence of cardiovascular malformations. Heart. 2000;83:414–419
  4. Botto LD, Correa A, Erickson JD. Racial and temporal variations in the prevalence of heart defects. Pediatrics. 2001;107:e32
  5. Hoffman JIE, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39:1890–1900
  6. Bosi G, Garani G, Scorrano M, et al. Temporal variability in birth prevalence of congenital heart defects as recorded by a general birth defects registry. J Pediatr. 2003;142:690–698
  7. Stephensen SS, Sigfusson G, Eiriksson H, et al. Congenital cardiac malformations in Iceland from 1990 through 1999. Cardiol Young. 2004;14:396–401
  8. Jenkins KJ, Correa A, Feinstein JA, et al. Non-inherited risk factors and congenital cardiovascular defects: Current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007;115:2995–3014
  9. Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population: changing prevalence and age distribution. Circulation. 2007;115:163–172
  10. Rosamond W, Flegal K, Friday G, et al. Heart Disease and Stroke Statistics–2007 Update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69–e171
  11. Wurst KE, Ephross SA, Loehr J, et al. Evaluation of the General Practice Research Database congenital heart defects prevalence: comparison to United Kingdom national systems. Birth Defects Res A Clin Mol Teratol. 2007;79:309–316
  12. International Clearinghouse for Birth Defects. Surveillance and research. Available at: http://www.icbdsr.org. Last accessed June 23, 2008.
  13. Billett J, Majeed A, Catzoulis M, et al. Trends in hospital admissions, in-hospital case fatality and population mortality from congenital heart disease in England, 1994 to 2004. Heart. 2008;94:342–348
  14. Layde PM, Dooley K, Erickson JD, et al. Is there an epidemic of ventricular septal defects in the U.S.A.?. Lancet. 1980;Feb 23:407–408
  15. Hoffman JIE, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J. 2004;147:425–439
  16. National Center for Health Statistics . Births/Demographics 2005. CDC, US Department for Health and Human Services; 2008;Available at: http://www.cdc.gov/nchs/Last accessed May 9, 2008
  17. Pierpont ME, Basson CT, Benson DW, et al. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007;115:3015–3038
  18. Laursen HB. Some epidemiological aspects of congenital heart disease in Denmark. Acta Paediatr Scand. 1980;69:619–624
  19. UK EUROCAT Central Registry. Prevalence data tables 1980-2005. Available at: http://www.eurocat.ulster.ac.uk/. Last accessed July 3, 2008.
  20. Botto LD, Lin AE, Riehle-Colarusso T, et al. Seeking causes: Classifying and evaluating congenital heart defects in etiologic studies. Birth Defects Res A Clin Mol Teratol. 2007;79:714–727
  21. Kirby ML. Cardiac development. Oxford: Oxford University Press; 2007;
  22. Reller MD, Strickland MJ, Riehle-Colarusso T, et al. Prevalence of congenital heart defects in Metropolitan Atlanta, 1998-2005. J Pediatr. 2008;
  23. Martin GR, Perry LW, Ferencz C. Increased prevalence of ventricular septal defect: epidemic or improved diagnosis. Pediatrics. 1989;83:200–203
  24. Meberg A, Otterstad JE, Frøland G, et al. Increasing incidence of ventricular septal defects by improved detection rate. Acta Paediatr. 1994;83:653–657
  25. Mokdad AH, Bowman BA, Ford ES, et al. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:1195–1200
  26. Lisi A, Botto LD, Rittler M, et al. Sex and congenital malformations: an international perspective. Am J Med Genet. 2005;134A:49–57
  27. Samánek M. Boy:girl ratio in children born with different forms of cardiac malformation: a population-based study. Pediatr Cardiol. 1994;15:53–57
  28. Stoll C, Alembik Y, Dott B, et al. Impact of prenatal diagnosis on live birth prevalence of children with congenital anomalies. Ann Genet. 2002;45:115–121
  29. Frank L. Epidemiology. When an entire country is a cohort. Science. 2000;287:2398–2399

PII: S0002-8703(08)00907-1

doi: 10.1016/j.ahj.2008.10.017

American Heart Journal
Volume 157, Issue 3 , Pages 467-473.e1 , March 2009