American Heart Journal
Volume 157, Issue 1 , Pages 60.e1-60.e9 , January 2009

Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non–ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: Results of the Platelet Responsiveness to Aspirin and Clopidogrel and Troponin Increment after Coronary intervention in Acute coronary Lesions (PRACTICAL) Trial

  • Gerald Yong, MBBS(Hons)

      Affiliations

    • Royal Perth Hospital, Perth, Western Australia, Australia
    • ,
  • Jamie Rankin, MBBS

      Affiliations

    • Royal Perth Hospital, Perth, Western Australia, Australia
    • Corresponding Author InformationReprint requests: Jamie Rankin, MBBS, Royal Perth Hospital, Perth, WA, Australia.
    • ,
  • Louise Ferguson, BAppSc

      Affiliations

    • Royal Perth Hospital, Perth, Western Australia, Australia
    • ,
  • Jim Thom, MSc

      Affiliations

    • Royal Perth Hospital, Perth, Western Australia, Australia
    • ,
  • John French, MBChB, PhD

      Affiliations

    • Liverpool Hospital, Sydney, New South Wales, Australia
    • ,
  • David Brieger, MBBS, PhD

      Affiliations

    • Concord Hospital, Concord, New South Wales, Australia
    • ,
  • Derek P. Chew, MBBS, MPH

      Affiliations

    • Flinders University, Bedford Park, South Australia, Australia
    • ,
  • Ron Dick, MBBS

      Affiliations

    • Epworth Hospital, Richmond, Victoria, Australia
    • ,
  • David Eccleston, MBBS, MMedSci

      Affiliations

    • Royal Melbourne Hospital, Parkville, Victoria, Australia
    • ,
  • Bernard Hockings, MD, BS

      Affiliations

    • University of Western Australia, Nedlands, Western Australia, Australia
    • ,
  • Darren Walters, MBBS, Mphil

      Affiliations

    • Prince Charles Hospital, Chermside, Queensland, Australia
    • ,
  • Alan Whelan, MBBS, BSc

      Affiliations

    • Fremantle Hospital, Fremantle, Western Australia, Australia
    • ,
  • John W. Eikelboom, MBBS

      Affiliations

    • Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Received 6 June 2008 ,Accepted 29 September 2008.

  • Image Result

    (A) ADP-induced platelet aggregation by randomization for the entire cohort. (B) ADP-induced platelet aggregation by randomization in patients treated with PCI. CV, Coefficient of variation.

    (A) ADP-induced platelet aggregation by randomization for the entire cohort. (B) ADP-induced platelet aggregation by randomization in patients treated with PCI. CV, Coefficient of variation.

  • Image Result

    (A) Incidence of post-PCI myonecrosis by quartile of platelet aggregation (n = 140). (B) Incidence of 6-month major adverse cardiac events (composite of death, nonfatal MI, nonfatal stroke, hospitaliz

    (A) Incidence of post-PCI myonecrosis by quartile of platelet aggregation (n = 140). (B) Incidence of 6-month major adverse cardiac events (composite of death, nonfatal MI, nonfatal stroke, hospitalization for recurrent ischemia) by quartile of platelet aggregation (n = 256). Plt Agg, Optical platelet aggregometry.

 Clinical Trial Registration Information: Australian Clinical Trials Registry (http://www.actr.org.au/) number ACTRN012605000581662.

 This study was supported by an unrestricted educational grant from Sanofi-Aventis, Sydney, Australia.

PII: S0002-8703(08)00831-4

doi: 10.1016/j.ahj.2008.09.024

American Heart Journal
Volume 157, Issue 1 , Pages 60.e1-60.e9 , January 2009

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