American Heart Journal
Volume 157, Issue 1 , Pages 148.e1-148.e5 , January 2009

Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel

  • Jolanta M. Siller-Matula, MD

      Affiliations

    • Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    • ,
  • Alexander O. Spiel, MD

      Affiliations

    • Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    • ,
  • Irene M. Lang, MD

      Affiliations

    • Department of Cardiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Gerhard Kreiner, MD

      Affiliations

    • Department of Cardiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Guenter Christ, MD

      Affiliations

    • Department of Cardiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Bernd Jilma, MD

      Affiliations

    • Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationReprint requests: Bernd Jilma, MD, Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

Received 24 August 2008 ,Accepted 25 September 2008.

  • Image Result

    Platelet reactivity index in the VASP phosphorylation assay in patients on clopidogrel with or without PPI: pantoprazole or esomeprazole. Data are presented as mean and 95% CI.

    Platelet reactivity index in the VASP phosphorylation assay in patients on clopidogrel with or without PPI: pantoprazole or esomeprazole. Data are presented as mean and 95% CI.

  • Image Result

    Adenosine diphosphate–induced platelet aggregation in patients on clopidogrel with or without PPI: pantoprazole or esomeprazole. Data are presented as mean and 95% CI.

    Adenosine diphosphate–induced platelet aggregation in patients on clopidogrel with or without PPI: pantoprazole or esomeprazole. Data are presented as mean and 95% CI.

 This study was supported by a grant from the Jubiläumsfond of the Austrian National Bank (Nr. 12565).

PII: S0002-8703(08)00822-3

doi: 10.1016/j.ahj.2008.09.017

American Heart Journal
Volume 157, Issue 1 , Pages 148.e1-148.e5 , January 2009

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