American Heart Journal
Volume 156, Issue 6 , Pages 1201.e1-1201.e11 , December 2008

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease: The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study

  • Renate Schnabel, MD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • Both authors contributed equally.
    • ,
  • Edith Lubos, MD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    • Both authors contributed equally.
    • ,
  • Claudia M. Messow

      Affiliations

    • The Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Christoph R. Sinning, MD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Tanja Zeller, PhD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Philipp S. Wild, MD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Dirk Peetz, MD

      Affiliations

    • The Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Diane E. Handy, PhD

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    • ,
  • Thomas Munzel, MD, FAHA

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Joseph Loscalzo, MD, PhD

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    • ,
  • Karl J. Lackner, MD

      Affiliations

    • The Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University, Mainz, Germany
    • ,
  • Stefan Blankenberg, MD

      Affiliations

    • Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
    • Corresponding Author InformationReprint requests: Stefan Blankenberg, MD, Department of Medicine II, Johannes Gutenberg-University, Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Received 17 June 2008 ,Accepted 8 September 2008.

  • Image Result

    A, Glutathione peroxidase 1 protein in HCAEC after 4 days of sodium selenite treatment. B, Glutathione peroxidase 1 activity levels in HCAEC after 4 days of sodium selenite treatment. *P < .0001, #P <

    A, Glutathione peroxidase 1 protein in HCAEC after 4 days of sodium selenite treatment. B, Glutathione peroxidase 1 activity levels in HCAEC after 4 days of sodium selenite treatment. *P < .0001, #P < .05 vs no treatment (n = 8). C, Glutathione peroxidase 1 protein levels in HCAEC after 4 days of Se-methyl-selenocysteine hydrochloride or seleno-L-methionine. D, Glutathione peroxidase 1 activity levels in HCAEC after 4 days of Se-methyl-selenocysteine hydrochloride or seleno-L-methionine. *P < .0001 vs no treatment (n = 9). Data are expressed as mean ± standard error of the mean.

  • Image Result
    Study design and patient sample of the SETCAP trial. ITT indicates intention to treat.

    Study design and patient sample of the SETCAP trial. ITT indicates intention to treat.

 The study was funded by an unrestricted grant from Biosyn Arzneimittel GmbH, Fellbach, Germany; by National Institutes of Health (NIH) (Bethesda, MD) grants HL 61795, HV 28178, and HL 81587 from the National Heart, Lung, and Blood Institute (J.L.) (Bethesda, MD); and by grants from the Deutsche Forschungsgemeinschaft (Bonn, Germany) LU 1452/1-1 (E.L.) and SCHN 1149/1-1 (R.S.).

PII: S0002-8703(08)00789-8

doi: 10.1016/j.ahj.2008.09.004

American Heart Journal
Volume 156, Issue 6 , Pages 1201.e1-1201.e11 , December 2008

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