American Heart Journal
Volume 156, Issue 5 , Pages 808-809 , November 2008

Phase I cardiovascular cell therapy clinical trials: Are we running with scissors?

Received 6 August 2008 ,Accepted 20 August 2008.

References 

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  2. Lipinski MJ, Biondi-Zoccai GG, Abbate A, et al. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 2007;50:1761–1767
  3. Burt RK, Loh Y, Pearce W, et al. Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. JAMA. 2008;299:925–936
  4. Nadal-Ginard B, Fuster V. Myocardial cell therapy at the crossroads. Nat Clinl Pract Cardiovasc Med. 2007;4:1
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  6. Kovacic JC, Macdonald P, Feneley MP, et al. Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor and an intracoronary CD133+ cell infusion in patients with chronic refractory ischemic heart disease: the GAIN I trial. Am Heart J. 2008;156:955–964
  7. Wilson RF, Henry TD. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor Double-edged swords. J Am Coll Cardiol. 2005;46:1649–1650
  8. Zbinden S, Zbinden R, Meier P, et al. Safety and efficacy of subcutaneous-only granulocyte-macrophage colony-stimulating factor for collateral growth promotion in patients with coronary artery disease. J Am Coll Cardiol. 2005;46:1636–1642
  9. Hill JM, Syed MA, Arai AE, et al. Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease. J Am Coll Cardiol. 2005;46:1643–1648
  10. Losordo DW, Schatz RA, White CJ, et al. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind randomized controlled trial. Circulation. 2007;115:3165–3172
  11. Henry TD, Satran D, Campbell AR, et al. Long-term mortality in patients with refractory angina. J Am Coll Cardiol. 2008;51:A227
  12. Strauss CE, Duval S, Walton DM, et al. A meta-analysis of the placebo effect in the treatment of refractory angina. Am J Cardiol. 2005;96:13H
  13. Loh PH, Cleland JG, Louis AA, et al. Enhanced external counterpulsation in the treatment of chronic refractory angina: a long-term follow-up outcome from the international enhanced external counterpulsation patient registry. Clin Cardiol. 2008;31:159–164

PII: S0002-8703(08)00732-1

doi: 10.1016/j.ahj.2008.08.017

American Heart Journal
Volume 156, Issue 5 , Pages 808-809 , November 2008

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