American Heart Journal
Volume 156, Issue 6 , Pages 1217-1222 , December 2008

Enhanced external counterpulsation improves systolic blood pressure in patients with refractory angina

  • Alex R. Campbell, MD

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Daniel Satran, MD

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Andrey G. Zenovich, MSc

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Kayla M. Campbell

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Julia C. Espel, BS

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Theresa L. Arndt, RN, MA

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Anil K. Poulose, MD

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Charlene R. Boisjolie, RN, MA

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • ,
  • Kim Juusola, RN

      Affiliations

    • Hennepin County Medical Center, Minneapolis, MN
    • ,
  • Bradley A. Bart, MD

      Affiliations

    • Hennepin County Medical Center, Minneapolis, MN
    • ,
  • Timothy D. Henry, MD

      Affiliations

    • Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN
    • Corresponding Author InformationReprint requests: Timothy D. Henry, MD, Minneapolis Heart Institute Foundation, 920 East 28th Street, Suite 40, Minneapolis, MN 55407.

Received 22 April 2008 ,Accepted 31 July 2008.

References 

  1. Gibbons RJ, Abrams J, Chatterjee K, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina). Circulation. 2003;107:149–158
  2. Manchanda A, Soran O. Enhanced external counterpulsation and future directions: step beyond medical management for patients with angina and heart failure. J Am Coll Cardiol. 2007;50:1523–1531
  3. Arora RR, Chou TM, Jain D, et al. The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes. J Am Coll Cardiol. 1999;33:1833–1840
  4. Loh PH, Cleland JG, Louis AA, et al. Enhanced external counterpulsation in the treatment of chronic refractory angina: a long-term follow-up outcome from the international enhanced external counterpulsation patient registry. Clin Cardiol. 2008;31:159–164
  5. Bonetti PO, Holmes DR, Lerman A, et al. Enhanced external counterpulsation for ischemic heart disease: what's behind the curtain?. J Am Coll Cardiol. 2003;41:1918–1925
  6. Feldman AM. Enhanced external counterpulsation: mechanism of action. Clin Cardiol. 2002;25(Suppl 2):II11–II15
  7. Michaels AD, Accad M, Ports TA, et al. Left ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsation. Circulation. 2002;106:1237–1242
  8. Barsness G, Feldman AM, Holmes DR, et al. The International EECP Patient Registry (IEPR): design, methods, baseline characteristics and acute results. Clin Cardiol. 2001;24:435–442
  9. Akhtar M, Wu GF, Du ZM, et al. Effect of external counterpulsation on plasma nitric oxide and endothelin-1 levels. Am J Cardiol. 2006;98:28–30
  10. Garanich JS, Pahakis M, Tarbell JM. Shear stress inhibits smooth muscle cell migration via nitric-oxide mediated downregulation of matrix metalloproteinase-2 activity. Am J Physiol Heart Circ Physiol. 2005;288:H2244–H2252
  11. Zhang Y, He X, Chen X, et al. Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress responsive gene expression in hypercholesterolemic pigs. Circulation. 2007;116:526–534
  12. Wei W, Jin H, Chen ZW, et al. Vascular endothelial growth factor–induced nitric oxide– and PGI2-dependent relaxation in human internal mammary arteries: a comparative study with KDR and Flt-1 selective mutants. J Cardiovasc Pharmacol. 2004;44:615–621
  13. Wu G, Du Z, Hu C, et al. Angiogenic effects of long-term enhanced external counterpulsation in a dog model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2006;290:H248–H254
  14. Barsheshet A, Hod H, Shechter M, et al. The effects of external counterpulsation therapy on circulating endothelial progenitor cells in patients with angina pectoris. Cardiology. 2007;110:160–166
  15. Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348:593–600
  16. Arora RR, Lopez S, Saric M. Enhanced external counterpulsation improves systolic function by echocardiography in patients with coronary artery disease. Heart Lung. 2005;34:122–125
  17. Gheorghiade M, Abraham WT, Albert NM, et al. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA. 2006;296:2217–2226
  18. Lee TT, Chen J, Cohen DJ, et al. The association between blood pressure and mortality in patients with heart failure. Am Heart J. 2006;151:76–83
  19. Soran O, Kennard ED, Kfoury AG, et al. Two-year clinical outcomes after enhanced external counterpulsation (EECP) therapy in patients with refractory angina pectoris and left ventricular dysfunction (report from The International EECP Patient Registry). Am J Cardiol. 2006;97:17–20

PII: S0002-8703(08)00664-9

doi: 10.1016/j.ahj.2008.07.024

American Heart Journal
Volume 156, Issue 6 , Pages 1217-1222 , December 2008

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