American Heart Journal
Volume 156, Issue 5 , Pages 954-963, November 2008

Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor, and an intracoronary CD133+ cell infusion in patients with chronic refractory ischemic heart disease: The G-CSF in Angina patients with IHD to stimulate Neovascularization (GAIN I) trial

  • Jason C. Kovacic, FRACP, PhD

      Affiliations

    • Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, New South Wales, Australia
    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • Current appointment: Translational Medicine Branch, National Heart, Lung and Blood Institute, Bethesda, MD
    • ,
  • Peter Macdonald, FRACP, MD, PhD

      Affiliations

    • Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, New South Wales, Australia
    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Michael P. Feneley, FRACP, MD

      Affiliations

    • Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, New South Wales, Australia
    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • David W.M. Muller, FRACP, MD

      Affiliations

    • Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, New South Wales, Australia
    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Judith Freund, FRACP

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Anthony Dodds, FRACP

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Sam Milliken, FRACP

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Helen Tao, MD, PhD

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Silviu Itescu, FRACP

      Affiliations

    • Columbia University, New York, New York
    • ,
  • John Moore, FRACP, MD

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • David Ma, FRACP, MD

      Affiliations

    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • ,
  • Robert M. Graham, FRACP, MD

      Affiliations

    • Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, New South Wales, Australia
    • St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
    • Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    • Corresponding Author InformationReprint requests: Robert Graham, FRACP, MD, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia.

Received 18 September 2007; accepted 14 April 2008.

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 The study was approved by the St Vincent's Hospital human research ethics committee, registered with the Australian Clinical Trials Registry (no. 12605000050651), supervised by an independent data and safety monitoring board (DSMB), and conducted with the informed consent of all subjects. Enrollment commenced January 2004, with the final follow-up scan performed July 2006.

PII: S0002-8703(08)00657-1

doi:10.1016/j.ahj.2008.04.034

American Heart Journal
Volume 156, Issue 5 , Pages 954-963, November 2008

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