American Heart Journal
Volume 156, Issue 5 , Pages 918-930 , November 2008

Cardiovascular sequelae of preeclampsia/eclampsia: A systematic review and meta-analyses

  • Sarah D. McDonald, MD, MSc

      Affiliations

    • Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    • Corresponding Author InformationReprint requests: Sarah D. McDonald, MD, MSc, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, 1200 Main St West, HSC 3N52B, Hamilton, Ontario, Canada L8N 3Z5.
  • ,
  • Ann Malinowski, MSc, MD

      Affiliations

    • Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
  • ,
  • Qi Zhou, PhD

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
  • ,
  • Salim Yusuf, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Canada
    • Population Health Research Institute, McMaster University, Hamilton, Canada
  • ,
  • Philip J. Devereaux, MD, PhD

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    • Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Canada

Received 29 February 2008 ,Accepted 26 June 2008.

References 

  1. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53–56
  2. Douglas KA, Redman CW. Eclampsia in the United Kingdom. BMJ. 1994;309:1395–1400
  3. Geographic variation in the incidence of hypertension in pregnancy . World Health Organization International Collaborative Study of Hypertensive Disorders of Pregnancy. Am J Obstet Gynecol. 1988;158:80–83
  4. Granger JP, Alexander BT, Llinas MT, et al. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension. 2001;38:718–722
  5. Zeek PM, Assali NS. Vascular changes in the decidua associated with eclamptogenic toxemia of pregnancy. Am J Clin Pathol. 1950;20:1099–1109
  6. Brosens JJ, Pijnenborg R, Brosens IA. The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature. Am J Obstet Gynecol. 2002;187:1416–1423
  7. Said J, Dekker G. Pre-eclampsia and thrombophilia. Best Pract Res Clin Obstet Gynaecol. 2003;17:441–458
  8. Ray JG. Dysmetabolic syndrome, placenta-mediated disease and future risk of cardiovascular disease. Fetal Matern Med Rev. 2004;15:1–16
  9. O'Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of preeclampsia: a systematic overview. Epidemiology. 2003;14:368–374
  10. Innes KE, Wimsatt JH, McDuffie R. Relative glucose tolerance and subsequent development of hypertension in pregnancy. Obstet Gynecol. 2001;97:905–910
  11. Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16:5–15
  12. Chambers JC, Fusi L, Malik IS, et al. Association of maternal endothelial dysfunction with preeclampsia. JAMA. 2001;285:1607–1612
  13. Chesley LC. Remote prognosis after eclampsia. Perspect Nephrol Hypertens. 1976;5:31–40
  14. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008–2012
  15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  16. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  17. Funai EF, Friedlander Y, Paltiel O, et al. Long-term mortality after preeclampsia. Epidemiology. 2005;16:206–215
  18. Kestenbaum B, Seliger SL, Easterling TR, et al. Cardiovascular and thromboembolic events following hypertensive pregnancy. Am J Kidney Dis. 2003;42:982–989
  19. Mann JI, Doll R, Thorogood M, et al. Risk factors for myocardial infarction in young women. Br J Prev Soc Med. 1976;30(2):94–100
  20. Haukkamaa L, Salminen M, Laivuori H, et al. Risk for subsequent coronary artery disease after preeclampsia. Am J Cardiol. 2004;93:805–808
  21. Croft P, Hannaford PC. Risk factors for acute myocardial infarction in women: evidence from the Royal College of General Practitioners' oral contraception study. BMJ. 1989;298:165–168
  22. Rosenberg L, Miller DR, Kaufman DW, et al. Myocardial infarction in women under 50 years of age. JAMA. 1983;250:2801–2806
  23. Thorogood M, Mann J, Murphy M, et al. Fatal stroke and use of oral contraceptives: findings from a case-control study. Am J Epidemiol. 1992;136:35–45
  24. Hannaford P, Ferry S, Hirsch S. Cardiovascular sequelae of toxaemia of pregnancy. Heart (British Cardiac Society). 1997;77:154–158
  25. Jonsdottir LS, Arngrimsson R, Geirsson RT, et al. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand. 1995;74:772–776
  26. Kaaja R, Kinnunen T, Luoto R. Regional differences in the prevalence of pre-eclampsia in relation to the risk factors for coronary artery disease in women in Finland. Eur Heart J. 2005;26:44–50
  27. Wilson BJ, Watson MS, Prescott GJ, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326:845
  28. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births. Lancet. 2001;357:2002–2006
  29. Irgens HU, Reisaeter L, Irgens LM, et al. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ. 2001;323:1213–1217
  30. Ray JG, Vermeulen MJ, Schull MJ, et al. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet. 2005;366:1797–1803
  31. Wikstrom AK, Haglund B, Olovsson M, et al. The risk of maternal ischaemic heart disease after gestational hypertensive disease. BJOG. 2005;112:1486–1491
  32. Bellamy L, Casas JP, Hingorani AD, et al. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335:974
  33. Magnussen EB, Vatten LJ, Lund-Nilsen TI, et al. Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. BMJ. 2007;335:978
  34. Rodie VA, Freeman DJ, Sattar N, et al. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy. [Review] [187 refs] Atherosclerosis. 2004;175:189–202
  35. Sibai BM, el-Nazer A, Gonzalez-Ruiz A. Severe preeclampsia-eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol. 1986;155:1011–1016
  36. Williams D. Pregnancy: a stress test for life. Curr Opin Obstet Gynecol. 2003;15:465–471
  37. Roberts JM, Taylor RN, Goldfien A. Endothelial cell activation as a pathogenetic factor in preeclampsia. Semin Perinatol. 1991;15:86–93
  38. Friedman S, Rabinerson D, Bar J, et al. Microalbuminuria following gestational diabetes. Acta Obstet Gynecol Scand. 1995;74:356–360
  39. Agrawal B, Berger A, Wolf K, et al. Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension. J Hypertens. 1996;14:223–228
  40. Jensen JS, Feldt-Rasmussen B, Strandgaard S, et al. Arterial hypertension, microalbuminuria, and risk of ischemic heart disease. Hypertension. 2000;35:898–903
  41. Nisell H, Lintu H, Lunell NO, et al. Blood pressure and renal function seven years after pregnancy complicated by hypertension. Br J Obstet Gynaecol. 1995;102:876–881
  42. North RA, Simmons D, Barnfather D, et al. What happens to women with preeclampsia? Microalbuminuria and hypertension following preeclampsia. Aust N Z J Obstet Gynaecol. 1996;36:233–238
  43. The World Factbook 2008 (CIA). Available at: https://www.cia.gov/library/publications/the-world-factbook/index.html. Last accessed February, 2008.
  44. Percentage who have experienced cardiovascular conditions (ever and recently) by sex and age, 2003, England. London: Department of Health (2004) Health Survey for England 2003.
  45. Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation. 1998;97:596–601
  46. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937–952

 This study was supported by the Regional Medical Association Scholarship Fund of Hamilton Health Sciences. Dr Yusuf holds the Heart and Stroke Foundation Chair in Cardiology. Dr Devereaux is supported by a Canadian Institutes of Health Research New Investigator Award.

PII: S0002-8703(08)00624-8

doi: 10.1016/j.ahj.2008.06.042

American Heart Journal
Volume 156, Issue 5 , Pages 918-930 , November 2008