American Heart Journal
Volume 156, Issue 6 , Pages 1155-1162.e2 , December 2008

Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility

  • Jeffrey L. Anderson, MD, FACC

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiology Division, University of Utah School of Medicine, Salt Lake City, UT
    • Corresponding Author InformationReprint requests: Jeffrey L. Anderson, MD, Cardiovascular Department, Intermountain Medical Center, 5121 S. Cottonwood Street, Murray, UT 84107.
    • ,
  • Benjamin D. Horne, PhD, MPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Genetic Epidemiology Division, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Matthew J. Kolek, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • Joseph B. Muhlestein, MD, FACC

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiology Division, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Chrissa P. Mower, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • James J. Park, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • ,
  • Heidi T. May, MSPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiology Division, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Nicola J. Camp, PhD

      Affiliations

    • Genetic Epidemiology Division, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • John F. Carlquist, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, UT
    • Cardiology Division, University of Utah School of Medicine, Salt Lake City, UT

Received 13 June 2008 ,Accepted 10 July 2008.

  • Image Result

    Predictive ability of rs238206 for angiographic CAD in the replication and combined association sets. A, Heterozygous patients. B, Homozygous patients. *Multivariable analysis could not be completed b

    Predictive ability of rs238206 for angiographic CAD in the replication and combined association sets. A, Heterozygous patients. B, Homozygous patients. *Multivariable analysis could not be completed because of incomplete risk data in the population control set. Angio, Angiographic.

  • Image Result
    Reclassification of intermediate risk subjects by addition of 9p21 genotype to Framingham risk assessment. y-Axis represents numbers of subjects in population based sample in low-, intermediate-, and

    Reclassification of intermediate risk subjects by addition of 9p21 genotype to Framingham risk assessment. y-Axis represents numbers of subjects in population based sample in low-, intermediate-, and high-risk categories before and after addition of 9p21 rs2383206 genotype to risk assessment. See text for details. FRS, Framingham risk score.

 The study was funded by grants from the National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL071878) (both in Bethesda, MD), and the Deseret Foundation, Intermountain Healthcare, Salt Lake City, UT.

 This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health.

PII: S0002-8703(08)00616-9

doi: 10.1016/j.ahj.2008.07.006

American Heart Journal
Volume 156, Issue 6 , Pages 1155-1162.e2 , December 2008

Article Tools

* Image Usage & Resolution