American Heart Journal
Volume 156, Issue 4 , Pages 662-673 , October 2008

Predictors of mortality after discharge in patients hospitalized with heart failure: An analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)

  • Christopher M. O'Connor, MD

      Affiliations

    • Duke University Medical Center/Duke Clinical Research Institute, Durham, NC
    • Corresponding Author InformationReprint requests: Christopher M. O'Connor, MD, Duke University Medical Center, Duke Clinical Research Institute, 2400 N. Pratt Street, Durham, NC 27705.
    • ,
  • William T. Abraham, MD

      Affiliations

    • The Ohio State University, Columbus, OH
    • ,
  • Nancy M. Albert, RN, PhD

      Affiliations

    • George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Robert Clare, MS

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • ,
  • Wendy Gattis Stough, PharmD

      Affiliations

    • Duke University Medical Center, Durham, NC
    • Department of Clinical Research, Campbell University School of Pharmacy, Research Triangle Park, NC
    • ,
  • Mihai Gheorghiade, MD

      Affiliations

    • Northwestern University, Chicago, IL
    • ,
  • Barry H. Greenberg, MD

      Affiliations

    • University of California San Diego–Hillcrest Medical Center, San Diego, CA
    • ,
  • Clyde W. Yancy, MD

      Affiliations

    • Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX
    • ,
  • James B. Young, MD

      Affiliations

    • George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Gregg C. Fonarow, MD

      Affiliations

    • University of California–Los Angeles Medical Center, Los Angeles, CA

Received 19 November 2007 ,Accepted 16 April 2008.

References 

  1. Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69–e171
  2. Adams KF, Fonarow GC, Emerman CL, et al. for the ADHERE Scientific Advisory Committee and Investigators Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149:209–216
  3. Cuffe MS, Califf RM, Adams KF, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002;287:1541–1547
  4. Binanay C, Califf RM, Hasselblad V, et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. JAMA. 2005;294:1625–1633
  5. Felker GM, Leimberger JD, Califf RM, et al. Risk stratification after hospitalization for decompensated heart failure. J Card Fail. 2004;10:460–466
  6. Goldberg RJ, Ciampa J, Lessard D, et al. Long-term survival after heart failure: a contemporary population-based perspective. Arch Intern Med. 2007;167:490–496
  7. Fonarow GC, Abraham WT, Albert NM, et al. Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and design. Am Heart J. 2004;148:43–51
  8. Fonarow GC, Abraham WT, Albert NM, et al. for the OPTIMIZE-HF Investigators and Hospitals Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA. 2007;297:61–70
  9. Gheorghiade M, Abraham WT, Albert NM, et al. for the OPTIMIZE-HF Investigators and Coordinators Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA. 2006;296:2217–2226
  10. Albert NM, Fonarow GC, Abraham WT, et al. Predictors of delivery of hospital-based heart failure patient education: a report from OPTIMIZE-HF. J Card Fail. 2007;13:189–198
  11. Fonarow GC, Abraham WT, Albert NM, et al. Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). Am Heart J. 2007;153:e1–e11
  12. Harrell FE. Regression Modeling Strategies With Applications to Linear Models, Logistic Regression, and Survival Analysis. New York: Springer-Verlag; 2006;
  13. Lee DS, Austin PC, Rouleau JL, et al. Predicting mortality among patients hospitalized for heart failure. JAMA. 2003;290:2581–2587
  14. Gottlieb SS, Abraham W, Butler J, et al. The prognostic importance of different definitions of worsening renal function in congestive heart failure. J Card Fail. 2002;8:136–141
  15. Krumholz HM, Chen YT, Vaccarino V, et al. Correlates and impact on outcomes of worsening renal function in patients > or =65 years of age with heart failure. Am J Cardiol. 2000;85:1110–1113
  16. Smith GL, Vaccarino V, Kosiborod M, et al. Worsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure?. J Card Fail. 2003;9:13–25
  17. Harjai KJ, Thompson HW, Turgut T, et al. Simple clinical variables are markers of the propensity for readmission in patients hospitalized with heart failure. Am J Cardiol. 2001;87:234–237
  18. de Denus S, Spinler SA, Jessup M, et al. History of depression as a predictor of adverse outcomes in patients hospitalized for decompensated heart failure. Pharmacotherapy. 2004;24:1306–1310
  19. Jiang W, Alexander J, Christopher E, et al. Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med. 2001;161:1849–1856
  20. Koenig HG. Depression in hospitalized older patients with congestive heart failure. Gen Hosp Psychiatry. 1998;20:29–43
  21. Jiang W, Kuchibhatla M, Cuffe MS, et al. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation. 2004;110:3452–3456
  22. O'Connor CM, Stough WG, Gallup DS, et al. Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry. J Card Fail. 2005;11:200–205
  23. Horwich TB, Fonarow GC, Hamilton MA, et al. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol. 2001;38:789–795
  24. Curtis JP, Selter JG, Wang Y, et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med. 2005;165:55–61
  25. Fonarow GC, Srikanthan P, Costanzo MR for the ADHERE Scientific Advisory Committee and Investigators. An obesity paradox in acute heart failure: analysis of body mass index and in-hospital mortality for 108,927 patients in ADHERE. Am Heart J. 2007;153:74–81
  26. Cotter G, Metzkor E, Kaluski E, et al. Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema. Lancet. 1998;351:389–393
  27. Domanski M, Norman J, Pitt B, et al. Diuretic use, progressive heart failure, and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol. 2003;42:705–708
  28. Hasselblad V, Stough WG, Shah MR, et al. Relation between diuretic dose and outcome in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail. 2007;9:1064–1069
  29. Neuberg GW, Miller AB, O'Connor CM, et al. Diuretic resistance predicts mortality in patients with advanced heart failure. Am Heart J. 2002;144:31–38
  30. Levy WC, Mozaffarian D, Linker DT, et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation. 2006;113:1424–1433
  31. Pocock SJ, Wang D, Pfeffer MA, et al. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J. 2006;27:65–75
  32. Fonarow GC, Adams KF, Abraham WT, et al. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA. 2005;293:572–580

 The OPTIMIZE-HF registry is registered: http://www.clinicaltrials.gov, study number NCT00344513.

 The OPTIMIZE-HF registry was supported by GlaxoSmithKline (Philadelphia, PA).

PII: S0002-8703(08)00323-2

doi: 10.1016/j.ahj.2008.04.030

American Heart Journal
Volume 156, Issue 4 , Pages 662-673 , October 2008

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