American Heart Journal
Volume 156, Issue 2 , Pages 216-226.e9 , August 2008

Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: A systematic review and meta-analysis of randomized controlled trials

  • Ahmed Abdel-Latif, MD, MSPH

      Affiliations

    • Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY
    • ,
  • Roberto Bolli, MD

      Affiliations

    • Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY
    • ,
  • Ewa K. Zuba-Surma, PhD

      Affiliations

    • Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY
    • ,
  • Imad M. Tleyjeh, MD, MSc

      Affiliations

    • Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN
    • Department of Medicine, King Fahd Medical City, Riyadh, Saudi Arabia
    • ,
  • Carlton A. Hornung, PhD, MPH

      Affiliations

    • Department of Epidemiology and Population Health, University of Louisville, School of Public Health and Information Sciences, Louisville, KY
    • ,
  • Buddhadeb Dawn, MD

      Affiliations

    • Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY
    • Corresponding Author InformationReprint requests: Buddhadeb Dawn, MD, FACC, Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, 550 S. Jackson St., ACB, 3rd floor, Louisville, KY 40292.

Received 14 January 2008 ,Accepted 29 March 2008.

References 

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  43. Suzuki K, Nagashima K, Arai M, et al. Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease. Circ J. 2006;70:430–437
  44. Ince H, Petzsch M, Kleine H, et al. Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial. Circulation. 2005;112(Suppl):I73–I80
  45. Ince H, Petzsch M, Kleine H, et al. Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation. 2005;112:3097–3106
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  48. Jadad A, Moore R, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17:1–12
  49. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–748
  50. Yusuf S, Peto R, Lewis J, et al. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis. 1985;27:335–371
  51. Higgins J, Thompson S, Deeks J, et al. Measuring inconsistency in meta-analysis. BMJ. 2003;327:557–560
  52. Ferguson D, White C, Schwartz J, et al. Influence of baseline ejection fraction and success of thrombolysis on mortality and ventricular function after acute myocardial infarction. Am J Cardiol. 1984;54:705–711
  53. Little W, Applegate R. Congestive heart failure: systolic and diastolic function. J Cardiothorac Vasc Anesth. 1993;7(4 (Suppl 2)):2–5
  54. Ellis SG, Penn MS, Bolwell B, et al. Granulocyte colony stimulating factor in patients with large acute myocardial infarction: results of a pilot dose-escalation randomized trial. Am Heart J. 2006;152:e9–e14
  55. Engelmann MG, Theiss HD, Hennig-Theiss C, et al. Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial. J Am Coll Cardiol. 2006;48:1712–1721
  56. Kang HJ, Kim HS, Koo BK, et al. Intracoronary infusion of the mobilized peripheral blood stem cell by G-CSF is better than mobilization alone by G-CSF for improvement of cardiac function and remodeling: 2-year follow-up results of the Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intra-Coronary Stem Cell Infusion (MAGIC Cell) 1 trial. Am Heart J. 2007;153:e1–e8
  57. Ince H, Petzsch M, Kleine HD, et al. Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial. Circulation. 2005;112(Suppl):I73–I80
  58. Leone AM, Galiuto L, Garramone B, et al. Usefulness of granulocyte colony-stimulating factor in patients with a large anterior wall acute myocardial infarction to prevent left ventricular remodeling (the rigenera study). Am J Cardiol. 2007;100:397–403
  59. Ripa RS, Jorgensen E, Wang Y, et al. Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial. Circulation. 2006;113:1983–1992
  60. Suzuki K, Nagashima K, Arai M, et al. Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease. Circ J. 2006;70:430–437
  61. Takano H, Hasegawa H, Kuwabara Y, et al. Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction. Int J Cardiol. 2007;122:41–47
  62. Valgimigli M, Rigolin GM, Cittanti C, et al. Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile. Eur Heart J. 2005;26:1838–1845
  63. Zohlnhofer D, Ott I, Mehilli J, et al. Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. Jama. 2006;295:1003–1010

 This meta-analysis and publication was supported in part by National Institutes of Health grants R01 HL-72410, HL-55757, HL-68088, HL-70897, HL-76794, and HL-78825.

PII: S0002-8703(08)00277-9

doi: 10.1016/j.ahj.2008.03.024

American Heart Journal
Volume 156, Issue 2 , Pages 216-226.e9 , August 2008

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