American Heart Journal
Volume 156, Issue 1 , Pages 23-30 , July 2008

Challenges in meta-analysis of randomized clinical trials for rare harmful cardiovascular events: The case of rosiglitazone

  • Adrian V. Hernandez, MD, MSc, PhD

      Affiliations

    • Department of Quantitative Health Sciences, Health Outcomes and Clinical Epidemiology Section, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
    • Corresponding Author InformationReprint requests: Adrian V. Hernandez, MD, MSc, PhD, Department of Quantitative Health Sciences/Wb4, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
    • ,
  • Esteban Walker, PhD

      Affiliations

    • Department of Quantitative Health Sciences, Biostatistics Section, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • John P.A. Ioannidis, MD, PhD

      Affiliations

    • Department of Hygiene and Epidemiology, Clinical Trials and Evidence-Based Medicine Unit, University of Ioannina School of Medicine, Ioannina, Greece
    • Department of Medicine, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, MA
    • ,
  • Michael W. Kattan, PhD

      Affiliations

    • Department of Quantitative Health Sciences, Health Outcomes and Clinical Epidemiology Section, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Received 7 January 2008 ,Accepted 4 March 2008.

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PII: S0002-8703(08)00162-2

doi: 10.1016/j.ahj.2008.03.002

American Heart Journal
Volume 156, Issue 1 , Pages 23-30 , July 2008

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