American Heart Journal
Volume 155, Issue 6 , Pages 1106-1113 , June 2008

Hospital-based comprehensive cardiac rehabilitation versus usual care among patients with congestive heart failure, ischemic heart disease, or high risk of ischemic heart disease: 12-Month results of a randomized clinical trial

  • Ann-Dorthe Olsen Zwisler, PhD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • National Institute of Public Health, Copenhagen, Denmark
    • Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark
    • Corresponding Author InformationReprint requests: Ann-Dorthe Zwisler, PhD, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, DK-2100 Copenhagen, Denmark.
    web address
    • ,
  • Anne Merete Boas Soja, PhD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Søren Rasmussen, PhD

      Affiliations

    • National Institute of Public Health, Copenhagen, Denmark
    • ,
  • Marianne Frederiksen, MD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Sadollah Abadini, MD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Jon Appel, MD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Hanne Rasmussen, PhD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Christian Gluud, DMSc

      Affiliations

    • Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Lars Iversen, DMSc

      Affiliations

    • Unit of Preventive Medicine and Health Promotion, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Bjarne Sigurd, MD

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • Mette Madsen, MSc

      Affiliations

    • National Institute of Public Health, Copenhagen, Denmark
    • ,
  • Jørgen Fischer-Hansen, DMSc

      Affiliations

    • Cardiac Rehabilitation Unit, Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
    • ,
  • for the DANREHAB Group

Received 5 July 2007 ,Accepted 26 December 2007.

References 

  1. Taylor RS, Brown A, Ebrahim S, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116:682–692
  2. Oldridge N, Guyatt G, Jones N, et al. Effects on quality of life with comprehensive rehabilitation after acute myocardial infarction. Am J Cardiol. 1995;67:1084–1089
  3. Lavie CJ, Milani RV. Effects of cardiac rehabilitation programs on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in a large elderly cohort. Am J Cardiol. 1995;76:177–179
  4. Hedback B, Perk J, Hornblad M, et al. Cardiac rehabilitation after coronary artery bypass surgery: 10-year results on mortality, morbidity and readmissions to hospital. J Cardiovasc Risk. 2001;8:153–158
  5. McAlister F, Lawson FM, Teo KK, et al. Randomised trials of secondary prevention programmes in coronary heart disease: systematic review. BMJ. 2001;323:957–961
  6. Rehabilitation of people with heart disease—Danish clinical guidelines. Copenhagen: Danish Heart Foundation and Danish Society of Cardiology; 1997;
  7. Vanhees L, Mc Gee HM, Dugmore LD, et al. The Carinex survey. Current guidelines and practices in cardiac rehabilitation within Europe. 1st ed.. Leuven: Acco; 1999;
  8. Leon AS, Franklin BA, Costa F, et al. Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2005;111:369–376
  9. Giannuzzi P, Saner H, Bjornstad H, et al. Secondary prevention through cardiac rehabilitation: position paper of the Working Group on Cardiac Rehabilitation and Exercise Physiology of the European Society of Cardiology. Eur Heart J. 2003;24:1273–1278
  10. Jolliffe JA, Rees K, Taylor RS, et al. Exercise-based rehabilitation for coronary heart disease (Cochrane review). Chichester: John Wiley & Sons; 2004;
  11. Todaro JF, Shen BJ, Niaura R, et al. Do men and women achieve similar benefits from cardiac rehabilitation?. J Cardiopulm Rehabil. 2004;24:45–51
  12. Pasquali SK, Alexander KP, Peterson ED. Cardiac rehabilitation in the elderly. Am Heart J. 2001;142:748–755
  13. Lavie CJ, Milani RV. Benefits of cardiac rehabilitation and exercise training programs in elderly coronary patients. Am J Geriatr Cardiol. 2001;10:323–327
  14. Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med. 2001;135:982–989
  15. UK Medical Research Counsil . A framework for development and evaluation of RCTs for complex interventions to improve health. United Kingdom: Medical Research Council; 2000;http://www.mrc.ac.uk/pdf-mrc_cpr.pdf
  16. Zwisler ADO, Schou L, Soja AMB, et al. A randomized clinical trial of hospital-based, comprehensive cardiac rehabilitation versus usual care for patients with congestive heart failure, ischemic heart disease or high risk of ischemic heart disease (the DANRHEAB Trial)—design, intervention and population. Am Heart J. 2005;150:899.e7–899.e16
  17. Andersen TF, Madsen M, Jorgensen J, et al. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull. 1999;46:263–268
  18. Zwisler ADO, Rasmussen S, Fischer-Hansen J. Plan for statistical analysis (The DANREHAB Trial). Copenhagen: National Institute of Public Health; 2004;http://www.cardiacrehabilitation.dk/Main_study.174+M5b490fa52c7.0.html
  19. Tooze JA, Grunwald GK, Jones RH. Analysis of repeated measures data with clumping at zero. Stat Methods Med Res. 2002;11:341–355
  20. Schulz KF, Chalmers I, Hayes RJ, et al. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408–412
  21. Gluud LL. Bias in clinical intervention research. Am J Epidemiol. 2006;163:493–501
  22. Lisspers J, Sundin O, Ohman A, et al. Long-term effects of lifestyle behavior change in coronary artery disease: effects on recurrent coronary events after percutaneous coronary intervention. Health Psychol. 2005;24:41–48
  23. Oldridge N. Assessing health-related quality of life: is it important when evaluation the effectiveness of cardiac rehabilitation?. J Cardiopulm Rehabil. 2003;23:26–28

☆ Financial support was granted by Copenhagen Hospital Corporation Research Council, Danish Heart Foundation, Danish Pharmacy Foundation of 1991, Danish Research Council, Danish Center for Evaluation and Health Technology Assessment, Denmark's Ministry of the Interior and Health, Development Fund of Copenhagen County, Villadsen Family Foundation, Eva and Henry Frænkel's Memorial Foundation, Builder LP Christensen's Foundation, Danish Animal Protection Foundation, Bristol Meyers Squibb, Merck Sharp and Dohme, AstraZeneca, The Copenhagen Trial Unit, and Bispebjerg Hospital.

PII: S0002-8703(08)00070-7

doi: 10.1016/j.ahj.2007.12.033

American Heart Journal
Volume 155, Issue 6 , Pages 1106-1113 , June 2008

Article Tools

* Image Usage & Resolution