American Heart Journal
Volume 155, Issue 6 , Pages 1059-1067 , June 2008

Achieving rapid reperfusion with primary percutaneous coronary intervention remains a challenge: Insights from American Heart Association's Get With the Guidelines program

  • Rajendra H. Mehta, MD, MS

      Affiliations

    • Duke Clinical Research Institute and Duke University Medical Center, Durham, NC
    • ,
  • Vincent J. Bufalino, MD

      Affiliations

    • Midwest Heart Specialists, Lombard, IL
    • Corresponding Author InformationReprint requests: Vincent Bufalino, MD, 801 S Washington 4th Floor, Edward Heart Hospital, Naperville, IL 60540.
    • ,
  • Wenqin Pan, PhD

      Affiliations

    • Duke Clinical Research Institute and Duke University Medical Center, Durham, NC
    • ,
  • Adrian F. Hernandez, MD

      Affiliations

    • Duke Clinical Research Institute and Duke University Medical Center, Durham, NC
    • ,
  • Christopher P. Cannon, MD

      Affiliations

    • Brigham and Women's Hospital, Boston, MA
    • ,
  • Gregg C. Fonarow, MD

      Affiliations

    • UCLA Medical Center, Los Angeles, CA
    • ,
  • Eric D. Peterson, MD, MPH

      Affiliations

    • Duke Clinical Research Institute and Duke University Medical Center, Durham, NC
    • ,
  • on behalf of the American Heart Association Get With the Guidelines Investigators

Received 12 November 2007 ,Accepted 17 January 2008.

References 

  1. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomized trials. Lancet. 2003;361:13–20
  2. Cannon CP, Gibson CM, Lambrew CT, et al. Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA. 2000;283:2941–2947
  3. De Luca G, Suryapranata H, Ottervanger JP, et al. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts. Circulation. 2004;109:1223–1225
  4. Antman E, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Available at http://www.acc.org/clinical/guidelines/stemi/index.pdf2004;[Accessed July 12, 2007].
  5. Rogers WJ, Dean LS, Moore PB, et al. Comparison of primary angioplasty versus thrombolytic therapy for acute myocardial infarction. Am J Cardiol. 1994;74:111–118
  6. Curtis JP, Portnay EL, Wang Y, et al. National Registry of Myocardial Infarction–4. The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction 2000-2002 findings from the National Registry of Myocardial Infarction–4. (NRMI-4). Am J Cardiol. 2006;47:1544–1552
  7. Nallamothu BK, Bates ER, Herrin J, et al. Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)–3/4 analysis. Circulation. 2005;111:761–767
  8. McNamara RL, Wang Y, Herrin J, et al. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2006;47:2180–2186
  9. Bradley EH, Herrin J, Wang Y, et al. Strategies for reducing the door to balloon time in acute myocardial infarction. N Engl J Med. 2006;355:2308–2320
  10. LaBresh KA, Glicklich R, Liljestrand J, et al. Using Get With The Guidelines to improve cardiovascular secondary prevention. Joint Comm J Quality Saf. 2003;29:539–550
  11. LaBresh KA, Tyler PA. A collaborative model for hospital-based cardiovascular secondary prevention. Q Manag Health Care. 2003;12:20–27
  12. LaBresh KA, Ellrodt AG, Glicklich RG, et al. Get With the Guidelines for cardiovascular secondary prevention: pilot results. Arch Int Med. 2004;164:203–209
  13. D2B: an alliance for quality—a Guidelines Applied in Practice Program. Available at www.d2balliance.org[Accessed July 12, 2007]
  14. Jacobs AK. Regional systems of care for patients with ST-elevation myocardial infarction: being at the right place at the right time. Circulation. 2007;116:689–692
  15. Available at http://www.accncdr.com/WebNCDR/NCDRDocuments/datadictdefsonlyv30.pdf[Accessed November 28, 2007]
  16. Nallamothu BK, Fox KAA, Kennelly BM, et al. Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. The Global Registry of Acute Coronary Events. Heart. 2007;93:1552–1555
  17. Angeja BG, Gibson CM, Chin R, et al. for the participants in the National Registry of Myocardial Infarction 2-3 Predictors of door-to-balloon delay in primary angioplasty. Am J Cardiol. 2002;89:1156–1161
  18. Zahn R, Schiele R, Schneider S, et al. Decreasing hospital mortality between 1994 and 1998 in patients with acute myocardial infarction treated with primary angioplasty but not in patients treated with intravenous thrombolysis-results from the pooled data of the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and the Myocardial Infarction Registry (MIR). J Am Coll Cardiol. 2000;36:2064–2071
  19. Stenestrand U, Lindback J, Wallentin L for the RIKS-HIA Registry. Long-term outcome of primary percutaneous coronary intervention vs. prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction. JAMA. 2006;296:1749–1756
  20. Eagle KA, Nallamothu B, Mehta RH, et al. Trends in acute reperfusion therapy for ST-elevation myocardial infarction from 1999 to 2004: We're getting better but we have a long way to go. Eur Heart J (in press).
  21. Zahn R, Vogt A, Zeymer U, et al. Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte. In-hospital time to treatment of patients with acute ST elevation myocardial infarction treated with primary angioplasty: determinants and outcome. Results from the registry of percutaneous coronary interventions in acute myocardial infarction of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte. Heart. 2005;91:1041–1046
  22. Eagle KA, Goodman SG, Avezum Á, et al. for the GRACE Investigators Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet. 2002;359:373–377
  23. Mehta RH, Harjai KJ, Cox DA, et al. Comparison of coronary stenting versus conventional balloon angioplasty on 5-year mortality in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2005;96:901–906
  24. Vaccarino V, Parsons L, Every NR, et al. for the National Registry of Myocardial Infarction 2 Participants Sex-based differences in early mortality after myocardial infarction. N Engl J Med. 1999;341:217–225
  25. Mehta RH, Marks D, Califf RM, et al. Differences in the clinical and angiographic features and outcomes in African American and Caucasians with acute myocardial infarction. Am J Med. 2006;119:70e1–70e8

 Funding source: Get With the Guidelines-CAD is sponsored by the American Heart Association with funding in part from an unrestricted education grant from the Merck-Schering Plough Partnership.

PII: S0002-8703(08)00056-2

doi: 10.1016/j.ahj.2008.01.010

American Heart Journal
Volume 155, Issue 6 , Pages 1059-1067 , June 2008

Article Tools

* Image Usage & Resolution