American Heart Journal
Volume 155, Issue 1 , Pages 55.e1-55.e9, January 2008

Inflammatory responses after intracoronary injection of autologous mononuclear bone marrow cells in patients with acute myocardial infarction

  • Svein Solheim, MD

      Affiliations

    • Department of Cardiology, Ullevål University Hospital, Oslo, Norway
    • Corresponding Author InformationReprint requests: Svein Solheim, MD, Department of Cardiology, Ullevål University Hospital, Kirkeveien 166, 0407 Oslo, Norway.
    • ,
  • Ingebjørg Seljeflot, PhD

      Affiliations

    • Department of Cardiology, Ullevål University Hospital, Oslo, Norway
    • Center for Clinical Research, Ullevål University Hospital, Oslo, Norway
    • ,
  • Ketil Lunde, MD

      Affiliations

    • Department of Cardiology, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • ,
  • Pål Aukrust, MD, PhD

      Affiliations

    • Research Institute for Internal Medicine, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • Section of Clinical Immunology and Infectious Diseases, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • ,
  • Arne Yndestad, PhD

      Affiliations

    • Research Institute for Internal Medicine, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • ,
  • Haakon Kiil Grøgaard, MD

      Affiliations

    • Department of Cardiology, Ullevål University Hospital, Oslo, Norway
    • ,
  • Svend Aakhus, MD, PhD

      Affiliations

    • Department of Cardiology, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • ,
  • Kolbjørn Forfang, MD, PhD

      Affiliations

    • Department of Cardiology, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    • ,
  • Harald Arnesen, MD, PhD

      Affiliations

    • Department of Cardiology, Ullevål University Hospital, Oslo, Norway

Received 3 July 2007; accepted 1 October 2007.

Background

Inflammatory responses after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) are not clarified. The aim of this study was to investigate the influence of intracoronary injection of mBMC on inflammatory mediators in patients with acute myocardial infarction (AMI).

Methods

Patients with AMI in the ASTAMI trial (N = 100) treated with percutaneous coronary intervention were randomized to intracoronary injections of mBMC or control. Fasting blood samples were drawn the day before stem cell transplantation (baseline 4-5 days after AMI) and 1 day, 3 days, 2 to 3 weeks, and 3 months after transplantation for determination of circulating levels of selected inflammatory markers and mRNA levels in whole blood samples.

Results

From baseline to day 1, the levels of interleukin 6 and the expression of tumor necrosis factor α mRNA increased significantly in the mBMC group compared to the control group (P < .05 for both).

The decrease in interleukin 6 levels from baseline to 2 to 3 weeks in the mBMC group was less pronounced than in the controls (P < .05), as was also the decrease in C-reactive protein levels from baseline to day 1 and day 3 in the mBMC group (P < .05). However, from baseline to 3 months the levels of tumor necrosis factor α and monocyte chemoattractant protein 1 increased less in the mBMC group (P < .05 for both).

Conclusion

Intracoronary injection of mBMC in patients with AMI induces a marked short-term inflammatory response, but a slightly reduced inflammation after 3 months which may have implications for the timing of stem cell transplantation in AMI.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 Dr S Solheim and Dr K Lunde are supported by research fellowships from the Norwegian Council on Cardiovascular Diseases, Oslo, Norway. Additional financial support was given by Ullevål University Hospital Scientific Advisory Council, Oslo, Norway.

PII: S0002-8703(07)00784-3

doi:10.1016/j.ahj.2007.10.005

American Heart Journal
Volume 155, Issue 1 , Pages 55.e1-55.e9, January 2008

Article Tools

* Image Usage & Resolution