American Heart Journal
Volume 155, Issue 1 , Pages 133-139 , January 2008

Effects of pretreatment with clopidogrel on nonemergent percutaneous coronary intervention after fibrinolytic administration for ST-segment elevation myocardial infarction: A Clopidogrel as Adjunctive Reperfusion Therapy–Thrombolysis in Myocardial Infarction (CLARITY-TIMI) 28 study

  • C. Michael Gibson, MS, MD

      Affiliations

    • TIMI Study Group
    • Cardiovascular Division
    • Corresponding Author InformationReprint requests: C. Michael Gibson, MS, MD, TIMI Study Group, 350 Longwood Avenue, First Floor, Boston MA 02115.
    • ,
  • Sabina A. Murphy, MPH

      Affiliations

    • TIMI Study Group
    • ,
  • Yuri B. Pride, MD

      Affiliations

    • Department of Medicine, Beth, Israel Deaconess Medical Center, Harvard Medical School,, Boston, MA
    • ,
  • Ajay J. Kirtane, MD, SM

      Affiliations

    • Cardiovascular Division
    • ,
  • Julian M. Aroesty, MD

      Affiliations

    • Cardiovascular Division
    • ,
  • Erica B. Stein, BA

      Affiliations

    • TIMI Study Group
    • ,
  • Lauren N. Ciaglo, BA

      Affiliations

    • TIMI Study Group
    • ,
  • Matthew C. Southard, BS

      Affiliations

    • TIMI Study Group
    • ,
  • Marc S. Sabatine, MD, MPH

      Affiliations

    • TIMI Study Group
    • Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Christopher P. Cannon, MD

      Affiliations

    • TIMI Study Group
    • Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Eugene Braunwald, MD

      Affiliations

    • TIMI Study Group
    • Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • for the TIMI Study Group

Received 14 July 2006 ,Accepted 27 August 2007.

References 

  1. Gibson CM, Karha J, Murphy SA, et al. Early and long-term clinical outcomes associated with reinfarction following fibrinolytic administration in the Thrombolysis in Myocardial Infarction trials. J Am Coll Cardiol. 2003;42:7–16
  2. Ohman EM, Califf RM, Topol EJ, et al. Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. TAMI Study Group. Circulation. 1990;82:781–791
  3. Gibson CM. Primary angioplasty compared with thrombolysis: new issues in the era of glycoprotein IIb/IIIa inhibition and intracoronary stenting. Ann Intern Med. 1999;130:841–847
  4. The TIMI Research Group. Immediate vs delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction. TIMI II A results. JAMA. 1988;260:2849–2858
  5. Simoons ML, Arnold AE, Betriu A, et al. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. Lancet. 1988;1:197–203
  6. Topol EJ, Califf RM, George BS, et al. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen activator in acute myocardial infarction. N Engl J Med. 1987;317:581–588
  7. Zeymer U, Uebis R, Vogt A, et al. Randomized comparison of percutaneous transluminal coronary angioplasty and medical therapy in stable survivors of acute myocardial infarction with single vessel disease: a study of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausarzte. Circulation. 2003;108:1324–1328
  8. Fernandez-Aviles PF, Alonso PJJ, Castro-Beiras PA, et al. Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. Lancet. 2004;364:1045–1053
  9. Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352:1179–1189
  10. Sabatine MS, Cannon CP, Gibson CM, et al. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA. 2005;294:1224–1232
  11. Sabatine MS, McCabe CH, Gibson CM, et al. Design and rationale of Clopidogrel as Adjunctive Reperfusion Therapy–Thrombolysis in Myocardial Infarction (CLARITY-TIMI) 28 trial. Am Heart J. 2005;149:227–233
  12. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879–888
  13. TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. N Engl J Med. 1985;312:932–936
  14. Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation. 2000;101:125–130
  15. In: Stata Statistical Software. 8.2 ed.. College Station (Tex): Stata Corporation; 2004;
  16. Schweiger MJ, Cannon CP, Murphy SA, et al. Early coronary intervention following pharmacologic therapy for acute myocardial infarction (the combined TIMI 10B-TIMI 14 experience). Am J Cardiol. 2001;88:831–836
  17. Gurbel PA, Serebruany VL, Shustov AR, et al. Effects of reteplase and alteplase on platelet aggregation and major receptor expression during the first 24 hours of acute myocardial infarction treatment. GUSTO-III Investigators. Global Use of Strategies to Open Occluded Coronary Arteries. J Am Coll Cardiol. 1998;31:1466–1473
  18. Gurbel PA, Hayes K, Bliden KP, et al. The platelet-related effects of tenecteplase versus alteplase versus reteplase. Blood Coagul Fibrinolysis. 2005;16:1–7
  19. Serebruany VL, Malinin AI, Callahan KP, et al. Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy. Am Heart J. 2003;145:636–642
  20. Serebruany VL, Gurbel PA. Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction. Arterioscler Thromb Vasc Biol. 1999;19:153–158
  21. Gibson CM, Cannon CP, Murphy SA, et al. Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction. Circulation. 2002;105:1909–1913
  22. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527–533
  23. Lewis BS, Mehta SR, Fox KA, et al. Benefit of clopidogrel according to timing of percutaneous coronary intervention in patients with acute coronary syndromes: further results from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Am Heart J. 2005;150:1177–1184
  24. Steinhubl SR, Berger PB, Mann JT. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288:2411–2420
  25. Quinn MJ, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword?. Circulation. 2002;106:379–385
  26. Xiao Z, Theroux P. Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol. 2004;43:1982–1988
  27. Quinn MJ, Bhatt DL, Zidar F, et al. Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2004;93:679–684
  28. Vivekananthan DP, Bhatt DL, Chew DP, et al. Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention. Am J Cardiol. 2004;94:358–360
  29. Stenestrand U, Wallentin L. Early statin treatment following acute myocardial infarction and 1-year survival. JAMA. 2001;285:430–436

 This study was supported in part by a grant from Sanofi-Aventis, Paris, France, and Bristol-Myers Squibb, Princeton, NJ.

PII: S0002-8703(07)00770-3

doi: 10.1016/j.ahj.2007.08.034

American Heart Journal
Volume 155, Issue 1 , Pages 133-139 , January 2008

Article Tools

* Image Usage & Resolution