American Heart Journal
Volume 155, Issue 1 , Pages 128-132 , January 2008

Use of endothelial progenitor cell capture stent (Genous Bio-Engineered R Stent) during primary percutaneous coronary intervention in acute myocardial infarction: Intermediate- to long-term clinical follow-up

  • Melissa Co, MD

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Edgar Tay, MBBS, MRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Chi Hang Lee, MBBS, MRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Kian Keong Poh, MBBChir, MRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Adrian Low, MBBS, MRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Jimmy Lim, MBBS, MRCP

      Affiliations

    • Tan Tock Seng Hospital, Singapore, Singapore
    • ,
  • Ing Han Lim, MBBS, MRCP

      Affiliations

    • Tan Tock Seng Hospital, Singapore, Singapore
    • ,
  • Yean Teng Lim, MBBS, FRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • ,
  • Huay Cheem Tan, MBBS, FRCP

      Affiliations

    • Cardiac Department, National University Hospital, Singapore, Singapore
    • Corresponding Author InformationReprint requests: Huay Cheem Tan, MBBS, FRCP, 5, Lower Kent Ridge Road, Level 3, Main Building, National University Hospital, Singapore 119074, Singapore.

Received 27 June 2007 ,Accepted 30 August 2007.

References 

  1. Grines CL. Should thrombolysis or primary angioplasty be the treatment of choice for acute myocardial infarction? Primary angioplasty—the strategy of choice. N Engl J Med. 1996;335:1313–1317
  2. Walter DH, Rittig K, Bahlmann FH, et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation. 2002;105:3017–3024
  3. Vasa M, Fichtlscherer S, Adler K, et al. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation. 2001;103:2885–2890
  4. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13–20
  5. Grines CL, Cox DA, Stone GW, et al. Coronary angioplasty with or without stent implantation for acute myocardial infarction. Stent Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med. 1999;341:1949–1956
  6. Saia F, Lemos PA, Lee CH, et al. Sirolimus-eluting stent implantation in ST-elevation acute myocardial infarction: a clinical and angiographic study. Circulation. 2003;108:1927–1929[Originally published online Oct 13, 2003]
  7. Lucas AR, Korol R, Pepine CJ. Inflammation in atherosclerosis some thoughts about acute coronary syndromes. Circulation. 2006;113:e728–e732
  8. Roy-Chaudhury P. Endothelial progenitor cells, neointimal hyperplasia, and hemodialysis vascular access dysfunction: novel therapies for a recalcitrant clinical problem. Circulation. 2005;112:3–5
  9. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor cells for angiogenesis. Science. 1997;275:964–966
  10. Shintani S, Murohara T, Ikeda H, et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation. 2001;103:2776–2779
  11. Aoki J, Serruys P, van Beusekom H, et al. Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth–First In Man) Registry. J Am Coll Cardiol. 2005;45:1574–1579
  12. Ii M, Losordo DW. Statins and the endothelium. Vascul Pharmacol. 2007;46:1–9
  13. Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA. 2005;293:2126–2130

 The study complies with the Declaration of Helsinki. The ethics committee of the National Health Care Group Domain Specific Review Board (DSRB) C has approved the research protocol. Informed consent was obtained from the subjects and/or their guardians for the study.

PII: S0002-8703(07)00767-3

doi: 10.1016/j.ahj.2007.08.031

American Heart Journal
Volume 155, Issue 1 , Pages 128-132 , January 2008

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