American Heart Journal
Volume 155, Issue 2 , Pages 316-323 , February 2008

Class effects of statins in elderly patients with congestive heart failure: A population-based analysis

  • Stéphane Rinfret, MD, MSc

      Affiliations

    • Division of Cardiology, Department of Medicine, Centre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Hassan Behlouli, PhD

      Affiliations

    • Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
    • ,
  • Mark J. Eisenberg, MD, MPH

      Affiliations

    • Division of Cardiology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Canada
    • Division of Clinical Epidemiology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Canada
    • ,
  • Karin Humphries, DSc

      Affiliations

    • Division of Cardiology, University of British Columbia and Centre for Health Evaluation and Outcome Science, Vancouver, British Columbia
    • ,
  • Jack V. Tu, MD, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    • ,
  • Louise Pilote, MD, MPH, PhD

      Affiliations

    • Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Canada
    • Division of Internal Medicine, McGill University Health Center, McGill University, Montreal, Canada
    • Corresponding Author InformationReprint requests: Louise Pilote, MD, MPH, PhD, Division of Internal Medicine and Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.

Received 20 April 2007 ,Accepted 13 September 2007.

References 

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  2. Raina A, Pickering T, Shimbo D. Statin use in heart failure: a cause for concern?. Am Heart J. 2006;152:39–49
  3. Cannon CP, Steinberg BA, Murphy SA, et al. Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. J Am Coll Cardiol. 2006;48:438–445
  4. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89–118
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  13. Horwich TB, MacLellan WR, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol. 2004;43:642–648
  14. Ray JG, Gong Y, Sykora K, Tu JV. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med. 2005;165:62–67
  15. Tousoulis D, Antoniades C, Bosinakou E, et al. Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure. Atherosclerosis. 2005;178:359–363
  16. Strey CH, Young JM, Molyneux SL, et al. Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure. Atherosclerosis. 2005;179:201–206
  17. Node K, Fujita M, Kitakaze M, et al. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation. 2003;108:839–843
  18. Laufs U, Wassmann S, Schackmann S, et al. Beneficial effects of statins in patients with non-ischemic heart failure. Z Kardiol. 2004;93:103–108
  19. Tousoulis D, Antoniades C, Bosinakou E, et al. Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure. Heart. 2005;91:27–31
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 Supported by grants from the Canadian Institutes of Health Research (#MOP53181, MOP19671).

PII: S0002-8703(07)00762-4

doi: 10.1016/j.ahj.2007.09.004

American Heart Journal
Volume 155, Issue 2 , Pages 316-323 , February 2008

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