American Heart Journal
Volume 155, Issue 1 , Pages 113.e1-113.e8 , January 2008

A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salvage in acute myocardial infarction (EVOLVE)

  • Ik-Kyung Jang, MD, PhD

      Affiliations

    • Massachusetts General Hospital and Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests: Ik-Kyung Jang, MD, PhD, Cardiology Division, Gray/Bigelow 800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.
    • ,
  • Neil J. Weissman, MD

      Affiliations

    • Washington Hospital Center, Washington DC
    • ,
  • Michael H. Picard, MD

      Affiliations

    • Massachusetts General Hospital and Harvard Medical School, Boston, MA
    • ,
  • Michael R. Zile, MD

      Affiliations

    • RHJ Department of Veterans Affairs Medical Center, and the Medical University of South Carolina, Charleston, SC
    • ,
  • Veronica Pettigrew, RN, BSN

      Affiliations

    • Mitsubishi Pharma America, Inc., Warren, NJ
    • ,
  • Steven Shen, PhD

      Affiliations

    • Mitsubishi Pharma America, Inc., Warren, NJ
    • ,
  • Jun Tatsuno, MSc

      Affiliations

    • Mitsubishi Pharma Corporation, Osaka, Japan
    • ,
  • Mark G. Hibberd, MD, PhD

      Affiliations

    • CardioCorp Cardiovascular Clinical Research, Lexington, MA
    • ,
  • Dan Tzivoni, MD

      Affiliations

    • Shaare Zedek Medical Centre, Jerusalem, Israel
    • ,
  • Frans J. Th. Wackers, MD

      Affiliations

    • Yale University Radionuclide CORE Laboratory, Yale University, New Haven, CT
    • ,
  • the EVOLVE Investigators

Received 11 April 2007 ,Accepted 20 August 2007.

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 The study was supported by a grant from Mitsubishi Pharma Corporation, Osaka, Japan.

 Conflict of interest IKJ, MHP, MGH, and FJTW: members of the EVOLVE study scientific advisory committee and received honoraria; NJW, MHP, and FJTW: directors of core laboratory and received payment for their work; VP and SS: full-time employees of Mitsubishi Pharma America Ltd, Warren, NJ; JT: a full-time employee of Mitsubishi Pharma Corporation in Japan; IKJ, MZ, and MH: consultant to Mitsubishi Pharma America Ltd, Warren, NJ.

PII: S0002-8703(07)00706-5

doi: 10.1016/j.ahj.2007.08.020

American Heart Journal
Volume 155, Issue 1 , Pages 113.e1-113.e8 , January 2008

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