American Heart Journal
Volume 155, Issue 1 , Pages 166-174 , January 2008

Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension

  • Kendall S. Hunter, PhD

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Po-Feng Lee, MSc

      Affiliations

    • Department of Bioengineering, Texas A&M University, College Station, TX
    • ,
  • Craig J. Lanning, BSc

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • D. Dunbar Ivy, MD

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • K. Scott Kirby, RDCS

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Lori R. Claussen, BSN, RN

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • K. Chen Chan, MD

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • ,
  • Robin Shandas, PhD

      Affiliations

    • Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO
    • Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO
    • Corresponding Author InformationReprint requests: Robin Shandas, PhD, Division of Cardiology, Cardiovascular Flow Research Laboratory, 1056 E 19th Ave, B-100, The Children's Hospital, Denver, CO 80218.

Received 24 July 2007 ,Accepted 12 August 2007.

References 

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  3. Bergel DH, Milnor WR. Pulmonary vascular impedance in the dog. Circ Res. 1965;16:401–415
  4. Weinberg C, Hertzberg J, Valdes-Cruz LM, et al. Extraction of pulmonary vascular compliance, PVR and RV work from single-pressure and Doppler flow measurements in children with pulmonary hypertension—a new method for evaluating reactivity: in vitro and clinical studies. Circulation. 2004;110:2609–2617
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  13. Domanski MJ, Mitchell GF, Norman JE, et al. Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction. J Am Coll Cardiol. 1999;33:951–958
  14. Mitchell GF, Moye LA, Braunwald E, et al. Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular Enlargement. Circulation. 1997;96:4254–4260
  15. St. John Sutton M. Aortic stiffness: a predictor of acute coronary events?. Eur Heart J. 2000;21:342–344
  16. Stefanadis C, Dernellis J, Tsiamis E, et al. Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. Eur Heart J. 2000;21:390–396
  17. Safar ME, London GM, Asmar R, et al. Recent advances on large arteries in hypertension. Hypertension. 1998;32:156–161
  18. Stefanadis C, Dernellis J, Vlachopoulos C, et al. Aortic function in arterial hypertension determined by pressure-diameter relation: effects of diltiazem. Circulation. 1997;96:1853–1858
  19. Dyer KL, Lanning CJ, Das BB, et al. Development and validation of a non-invasive color M-mode tissue Doppler imaging technique for measuring pulmonary artery compliance: in vitro and clinical studies. J Am Soc Echocardiogr. 2006;19:403–412

 This project was supported by in part by grants from the National Institutes of Health (R01-HL067393, T32-HL072738, SCCOR-HL081506, K24-HL084923, and M01-RR0069).

PII: S0002-8703(07)00689-8

doi: 10.1016/j.ahj.2007.08.014

American Heart Journal
Volume 155, Issue 1 , Pages 166-174 , January 2008

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