American Heart Journal
Volume 155, Issue 1 , Pages 62-68 , January 2008

Kidney dysfunction and fatal cardiovascular disease—an association independent of atherosclerotic events: Results from the Health, Aging, and Body Composition (Health ABC) study

  • Rajat Deo, MD

      Affiliations

    • Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD
    • ,
  • Christina L. Wassel Fyr, MS

      Affiliations

    • Department of Medicine, University of California, San Francisco, CA
    • Department of Epidemiology and Biostatistics, University of California, San Francisco, CA
    • ,
  • Linda F. Fried, MD, MPH

      Affiliations

    • The Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Renal Section, VA Pittsburgh Healthcare System, Pittsburgh, PA
    • ,
  • Anne B. Newman, MD, MPH

      Affiliations

    • Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA
    • Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • ,
  • Tamara B. Harris, MD, MS

      Affiliations

    • Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD
    • ,
  • Sara Angleman

      Affiliations

    • Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD
    • ,
  • Christie Green, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, University of Tennessee, Memphis, TN
    • ,
  • Stephen B. Kritchevsky, PhD

      Affiliations

    • J. Paul Sticht Center on Aging and Rehabilitation, Wake Forest Bowman Gray School of Medicine, Winston-Salem, NC
    • ,
  • Glenn M. Chertow, MD, MPH

      Affiliations

    • Department of Medicine, University of California, San Francisco, CA
    • Department of Epidemiology and Biostatistics, University of California, San Francisco, CA
    • ,
  • Steven R. Cummings, MD

      Affiliations

    • California Pacific Medical Center Research Institute, San Francisco, CA
    • ,
  • Michael G. Shlipak, MD, MPH

      Affiliations

    • General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA
    • Corresponding Author InformationReprint requests: Michael G. Shlipak, MD, MPH, University of California, San Francisco, General Internal Medicine Section, VA Medical Center (111A1), 4150 Clement Street, San Francisco, CA 94121.
    • ,
  • for the Health ABC study

Received 16 March 2007 ,Accepted 12 August 2007.

References 

  1. Fried LP, Kronmal RA, Newman AB, et al. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA. 1998;279:585–592
  2. Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  3. Kassirer JP. Clinical evaluation of kidney function-tubular function. N Engl J Med. 1971;285:499–502
  4. Kassirer JP. Clinical evaluation of kidney function-glomerular function. N Engl J Med. 1971;285:385–389
  5. Coll E, Botey A, Alvarez L, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29–34
  6. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40:221–226
  7. Erlandsen EJ, Randers E, Kristensen JH. Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scand J Clin Lab Invest. 1999;59:1–8
  8. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130:461–470
  9. Shlipak MG, Fyr CL, Chertow GM, et al. Cystatin C and mortality risk in the elderly: the Health, Aging, and Body Composition study. J Am Soc Nephrol. 2006;17:254–261
  10. Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352:2049–2060
  11. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
  12. Fried LF, Shlipak MG, Crump C, et al. Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals. J Am Coll Cardiol. 2003;41:1364–1372
  13. Shlipak MG, Fried LF, Crump C, et al. Cardiovascular disease risk status in elderly persons with renal insufficiency. Kidney Int. 2002;62:997–1004
  14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  15. Tonelli M, Wiebe N, Culleton B, et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol. 2006;17:2034–2047
  16. Koenig W, Twardella D, Brenner H, et al. Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin Chem. 2005;51:321–327
  17. Jernberg T, Lindahl B, James S, et al. Cystatin C: a novel predictor of outcome in suspected or confirmed non–ST-elevation acute coronary syndrome. Circulation. 2004;110:2342–2348

 Health ABC was supported through the National Institute on Aging contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106. This research was supported in part by the Intramural Research program of the NIH, National Institute on Aging.

PII: S0002-8703(07)00687-4

doi: 10.1016/j.ahj.2007.08.012

American Heart Journal
Volume 155, Issue 1 , Pages 62-68 , January 2008

Article Tools

* Image Usage & Resolution