Clinical InvestigationsValvular and Congenital Heart DiseaseEffect of pulmonary stenosis on pregnancy outcomes—A case-control study
Section snippets
Methods
The study was designed as a single-center, case-control evaluation of pregnant patients diagnosed with isolated PS in comparison with individually matched normal control patients. All subjects were followed at the high-risk obstetrics/cardiology clinic and delivered at the Los Angeles County/University of Southern California Medical Center between 1995 and 2006. For each patient, a normal control case that received prenatal care and delivered at the same medical center was selected to match the
Results
We evaluated the outcomes of 17 pregnant patients with isolated PS. None of the patients had significant pulmonary regurgitation, right ventricular dysfunction, or a history of valve repair. Eight pregnancies were evaluated retrospectively and 9 prospectively. The age at the time of pregnancy ranged between 16 and 36 years (mean, 25 ± 5.5); ethnic background was Hispanic in 15 (88%) and white in 2 (12%) subjects. Ten (59%) patients had mild PS with a mean peak transvalvular gradient of 34 ± 11
Discussion
Our study demonstrates no significant impact of PS on maternal and fetal well-being regardless of the severity. Most patients demonstrated clinical stability without a significant impact of pregnancy on functional status. These findings may not be surprising considering reports of high athletic activity in young patients with severe PS.8 These findings are in contrast to the effect of stenosis of other valves such as mitral and aortic on pregnancy outcomes. Studies in these populations have
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